TQC2731 Clinical Trial for the Treatment of Severe Asthma With Injection

Description

This study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial designed to evaluate the efficacy and safety of TQC2731 injection (420 mg Q4W) in adult subjects with inadequately controlled severe asthma. A total of 660 trial participants are expected to be enrolled, with trial participants randomized in a 1:1 ratio to receive either TQC2731 (420 mg Q4W) or placebo (Q4W) via subcutaneous (SC) administration.

Interventions

• TQC2731 injection (Drug)
  TQC2731 injection can specifically bind to the Thymic Stromal Lymphopoietin (TSLP) protein, blocking TSLP-dependent downstream signaling expression in engineered cells and inhibiting the production of inflammatory cytokines.
• Placebo (Drug)
  Placebo without drug substance.

Eligibility criteria

Conditions

Locations

• The People's Hospital of Bozhou — Bozhou, Anhui, China
• Anhui Chest Hoispital — Hefei, Anhui, China
• The First Affiliated Hospital of Anhui Medical University — Hefei, Anhui, China
• Lu'an People's Hospital of Anhui Province — Lu'an, Anhui, China
• Tongling People's Hospital — Tongling, Anhui, China
• Peking University First Hospital — Beijing, Beijing Municipality, China
• Beijing No.6 Hospital — Beijing, Beijing Municipality, China
• The First Affiliated Hospital of Xiamen University — Xiamen, Fujian, China
• Zhangzhou Municipal Hospital of Fujian — Zhangzhou, Fujian, China
• The First Hospital of Lanzhou University — Lanzhou, Gansu, China
• The Second Hospital & Clinical Medical School,Lanzhou University — Lanzhou, Gansu, China
• The Eighth Afliated Hospital of Southern Medical University The First people's Hospital of Shunde — Foshan, Guangdong, China
• The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
• Guangdong Provincial Hospital of Traditional Chinese Medicine — Guangzhou, Guangdong, China
• Guangzhou First People's Hospital — Guangzhou, Guangdong, China
• Third People's Hospital of Huizhou — Huizhou, Guangdong, China
• Zhongshan City People's Hospital — Zhongshan, Guangdong, China
• The Affiliated Hospital of Medical University — Guilin, Guangxi, China
• Guilin People'S Hospital — Guilin, Guangxi, China
• Guizhou Provincial People's Hospital — Guiyang, Guizhou, China
• The First Affiliated Hospital of Hainan Medical University — Haikou, Hainan, China
• Cangzhou Hospital of Integrated TCM-WM·Hebei — Cangzhou, Hebei, China
• Xingtai People's Hospital — Xingtai, Hebei, China
• Da Qing Long Nan Hospital — Daqing, Heilongjiang, China
• The Fourth Affiliated Hospital of Harbin Medical University — Harbin, Heilongjiang, China
• The First Hospital of Qiqihar — Qiqihar, Heilongjiang, China
• The People's Hospital of Anyang — Anyang, Henan, China
• The Second People's Hospital of Jiaozuo City — Jiaozuo, Henan, China
• Luo Yang Dong Fang People's Hospital — Luoyang, Henan, China
• Xinxiang Central Hospital — Xinxiang, Henan, China
• Henan Provincial People's Hospital — Zhengzhou, Henan, China
• Zhengzhou Central Hospital — Zhengzhou, Henan, China
• Zhoukou Central hospital — Zhoukou, Henan, China
• Enshi Tujia and Miao Autonomous Prefecture Central Hospital — Enshi, Hubei, China
• The Central Hospital of Wuhan — Wuhan, Hubei, China
• Changsha Central Hospital — Changsha, Hunan, China
• The Second Xiangya Hospital of Central South University — Changsha, Hunan, China
• Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) — Changsha, Hunan, China
• Loudi central hospital — Loudi, Hunan, China
• Baotou Central Hospital — Baotou, Inner Mongolia, China
• The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology — Baotou, Inner Mongolia, China
• Chifeng Municipal Hospital — Chifeng, Inner Mongolia, China
• The Affiliated Hospital of Inner Mongolia Medical University — Hohhot, Inner Mongolia, China
• Inner Mongolia Autonomous Region People's Hospital — Hohhot, Inner Mongolia, China
• Affiliated Hospital of Jiangsu University — Nanjing, Jiangsu, China
• Wuxi Second People's Hospital — Wuxi, Jiangsu, China
• The Affiliated Hospital of Xuzhou Medical University — Xuzhou, Jiangsu, China
• Xuzhou Central Hospital — Xuzhou, Jiangsu, China
• Northern Jiangsu People's Hospital — Yangzhou, Jiangsu, China
• Jiangsu University Affiliated Hospital — Zhenjiang, Jiangsu, China
• The First Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
• Pingxiang People's Hospital — Pingxiang, Jiangxi, China
• Jilin University Second Hospital — Changchun, Jilin, China
• The First Hospital of Jlin University — Changchun, Jilin, China
• Gansu Provincial Hospital — Gansu, Lanzhou, China
• Dalian Municipal Central Hospital — Dalian, Liaoning, China
• Genertec Liaoyou Gem Flower Hospital — Panjin, Liaoning, China
• Shengjing Hospital affiliated to China Medical University — Shenyang, Liaoning, China
• Shengjing Hospital of China Medical University — Shenyang, Liaoning, China
• People's Liberation Army North Theater General Hospital — Shenyang, Liaoning, China
• The First People's Hospital of Yinchuan — Yinchuan, Ningxia, China
• The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China
• The First Affiliated Hospital of Xi'an Medical Universi — Xi'an, Shaanxi, China
• The Second Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China
• Xi'an International Medical Center Hospital — Xi'an, Shaanxi, China
• Xi'an People's Hospital (Xi'an Fourth Hospital) — Xi'an, Shaanxi, China
• Heze Municipal Hospital — Heze, Shandong, China
• Central Hospital Affiliated to Shandong First Medical University — Jinan, Shandong, China
• Affiliated Hospital of Jining Medical Hospital — Jining, Shandong, China
• The Affiliated Hospital of Qingdao University — Qingdao, Shandong, China
• The Second Affiliated Hospital of Shandong First Medical University — Tai’an, Shandong, China
• Weifang NO.2 People's Hospital — Weifang, Shandong, China
• Yantai Yuhuangding Hospital — Yantai, Shandong, China
• Zaozhuang Municipal Hospital — Zaozhuang, Shandong, China
• Zibo Central Hospital — Zibo, Shandong, China
• Rui Jin Hospital Shanghai Jiaotong University School of Medical — Shanghai, Shanghai Municipality, China
• Fudan University Affiliated Zhongshan Hospital — Shanghai, Shanghai Municipality, China
• Shanghai General Hospital — Shanghai, Shanghai Municipality, China
• Shanghai Pudong Hospital, Fudan University Affiliated Pudong Medical Center — Shanghai, Shanghai Municipality, China
• Wusong Central Hospital, Baoshan District, Shanghai — Shanghai, Shanghai Municipality, China
• Jincheng General Hospital — Jincheng, Shanxi, China
• Shanxi Bethune Hospital — Taiyuan, Shanxi, China
• No.215 Hospital of Shaanxi Nuclear Industry — Xianyang, Shanxi, China
• Yangquan Coal Industry Group General Hospital — Yangquan, Shanxi, China
• West China Hospital, Sichuan University — Chengdu, Sichuan, China
• Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital — Chengdu, Sichuan, China
• Chengdu Fifth People's Hospital — Chengdu, Sichuan, China
• Suining Central Hospital — Suining, Sichuan, China
• Yibin Second People's Hospital — Yibin, Sichuan, China
• Tianjin Medical University General Hospital — Tianjin, Tianjin Municipality, China
• Tianjin 4th Center Hospital — Tianjin, Tianjin Municipality, China
• The First Affiliated Hospital of Shihezi University — Shihezi, Xinjiang, China
• First Affiliated Hospital of Xinjiang Medical University — Ürümqi, Xinjiang, China
• People's Hospital of Xinjiang Uygur Autonomous Region — Ürümqi, Xinjiang, China
• The First People's Hospital of Yunnan Province — Kunming, Yunnan, China
• The First Affiliated of Kumming Medical University — Kunming, Yunnan, China
• The People's Hospital of Yuyao — Yuyao, Zhejaing, China
• Jinhua Municipal Central Hospital — Jinhua, Zhejiang, China
• The First Affiliated Hospital of Ningbo University — Ningbo, Zhejiang, China
• Taizhou Central Hospital(Taizhou University Hospital) — Taizhou, Zhejiang, China
• The 2nd School of Medicine,WMU/The 2nd Affiliated Hospital and Yuying Children's Hospital of WMU — Wenzhou, Zhejiang, China