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RECRUITING Not applicable ClinicalTrials.gov

Surveillance of Pancreatic Health After Diabetes Diagnosis

Sponsor: University Hospital Southampton NHS Foundation Trust • ClinicalTrials.gov ID: NCT06803771

Registry updated: 2026-09-28
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Description

The goal of this interventional study is to evaluate if the novel diagnostic blood test, called Avantect can early detect pancreatic cancer in patients diagnosed with type 2 diabetes or with elevated sugar levels within the last 200 days. Participants will: * attend 3 study visits over 12 months time * provide a blood sample at each study visit * complete an anxiety questionnaire at each visit.

Interventions

  • Avantect Pancreatic Cancer Test (Device)
    Avantect test

Eligibility criteria

Inclusion Criteria: * 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth) * Confirmed type 2 DM diagnosis established within the last 200 days or an initial elevated HbA1c ≥ 48 mmol/mol or 6.5% obtained within the last 200 days. This includes people who have a first elevated HbA1c (≥ 48 mmol/mol or 6.5%) within the last 200 days, even if subsequent HbAc1 measurements return to the the normal range. * Willing to provide up to 30 mL of blood for each study visit * Willing and eligible to undergo MRI or CT scan * Understands the study process and is willing to take part in the study and sign the informed consent form Exclusion Criteria: * Prior type I or type II DM diagnosis or an initial HbA1c ≥ 48 mmol/mol or 6.5% obtained prior to the 200-day inclusion window, except gestational elevated HbA1c. * A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis * Under investigation for or confirmed pancreatic cancer * Under investigation/surveillance for pancreatic cyst * Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months * Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years * BMI \> 40 at the time of consent * Blood transfusion within 1 month * Solid organ transplant recipient * Currently pregnant * Needing dialysis

Conditions

Diabetes Mellitus Pancreatic Cancer, Adult

Locations

  • Ashfields Primary Care Centre — Sandbach, Cheshire, United Kingdom
  • Maidstone and Tunbridge Wells NHS Trust — Maidstone, Kent, United Kingdom
  • Forest Medical Group — Leicester, Leicester Forest East, United Kingdom
  • South Leicestershire Medical Group — Kibworth Beauchamp, Leicestershire, United Kingdom
  • Peel Croft Surgery — Burton-on-Trent, Staffordshire, United Kingdom
  • Kingswinford Medical Practice — Kingswinford, Staffordshire, United Kingdom
  • Park Medical Centre — Leek, Staffordshire, United Kingdom
  • Trinity Court Surgery — Stratford-upon-Avon, Staffordshire, United Kingdom
  • Brockwood Medical Practice — Brockham, Surrey, United Kingdom
  • Integrated Care Partnership/ The Old Cottage Hospital — Epsom, Surrey, United Kingdom
  • Warlingham Green Medical Practice — Warlingham, Surrey, United Kingdom
  • Ashton Medical Group — Ashton-under-Lyne, United Kingdom
  • Yardley Wood Health Centre — Birmingham, United Kingdom
  • Bournemouth Research Hub — Bournemouth, United Kingdom
  • Eastham Group Practice — Bromborough, United Kingdom
  • Willesden Medical Centre — London, United Kingdom
  • South Westminster Centre — London, United Kingdom
  • The Cuckoo Lane Practice — London, United Kingdom
  • Bodey Medical Centre — Manchester, United Kingdom
  • Bowland Medical Practice — Manchester, United Kingdom
  • The Maples Medical Centre — Manchester, United Kingdom
  • King's Mill Hospital (Sherwood Forest) Research Van — Nottingham, United Kingdom
  • Portsmouth Research Hub — Portsmouth, United Kingdom
  • Hazelvalley Family Practice — Rossendale, United Kingdom
  • Pembroke Centre (Hillingdon) — Ruislip, United Kingdom
  • Southampton Research Hub (Shirley Research Hub) — Southampton, United Kingdom
  • Moorgreen Hospital — Southampton, United Kingdom
  • Balance Street Health Centre — Uttoxeter, United Kingdom
  • Civic Centre — Uxbridge, United Kingdom
  • Quinton Practice — Walsall, United Kingdom
  • Weymouth Research Hub — Weymouth, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record