RECRUITING Phase 4 ClinicalTrials.gov

Role of Menopause in Thermoregulation

Sponsor: Penn State University • ClinicalTrials.gov ID: NCT06798571

Registry updated: 2026-10-02

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Description

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Interventions

Elagolix Oral Tablet (Drug)
2 x 200 mg tablet
Estradiol patch (Drug)
0.05 mg/day patch
cellulose placebo (Other)
placebo tablet
placebo patch (Other)
placebo patch

Eligibility criteria

Inclusion Criteria: * Women ages 42-64 Exclusion Criteria: * Chron's disease, diverticulitis, or similar gastrointestinal disease * Abnormal resting exercise electrocardiogram (ECG) * Tobacco use * High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor * Assessment * Using hormone therapy * Using hormonal contraceptives

Conditions

Menopause Aging

Locations

Noll Laboratory — University Park, Pennsylvania, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record

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