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RECRUITING Not applicable ClinicalTrials.gov

Vancomycin Reduction Practices (VRP) in the NICU

Sponsor: Children's Hospital of Philadelphia • ClinicalTrials.gov ID: NCT06772675

Registry updated: 2026-09-24
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Description

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.

Interventions

  • External Facilitation (Behavioral)
    Designated external facilitators will conduct monthly meetings with local champions at each site. Designated facilitators will follow the developed facilitation guide, that includes content area to cover in each meeting, case scenarios as examples, and tips on how to communicate and support the internal facilitators. The goal is to enable problem-solving and support the local champion in implementing VRP with fidelity

Eligibility criteria

Inclusion Criteria: * Level III NICU * Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN) * Recruited by study team Exclusion Criteria: * Site not recruited for the study

Conditions

Antibiotic Stewardship Neonatal Sepsis, Late-Onset Vancomycin

Locations

  • Kaiser Permanente Modesto Medical Center — Modesto, California, United States
  • Kaiser Permanente East Bay - Oakland Medical Center — Oakland, California, United States
  • Kaiser Permanente Roseville Medical Center — Roseville, California, United States
  • Kaiser Permanente San Francisco Medical Center — San Francisco, California, United States
  • Kaiser Permanente San Leandro Medical Center — San Leandro, California, United States
  • Kaiser Permanente Santa Clara Medical Center — Santa Clara, California, United States
  • Kaiser Permanente Walnut Creek Medical Center — Walnut Creek, California, United States
  • Medical Center of Princeton — Plainsboro, New Jersey, United States
  • Virtua Voorhees — Voorhees Township, New Jersey, United States
  • Lancaster General Hospital — Lancaster, Pennsylvania, United States
  • Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
  • Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
  • Chester County Hospital — West Chester, Pennsylvania, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record