A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma
Sponsor: Janssen Research & Development, LLC • ClinicalTrials.gov ID: NCT06768489
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The primary purpose of this study for Part 1 (Dose Escalation) is to identify the safe effective dose (recommended Phase 2 doses \[RP2Ds\]) and schedule for JNJ-79635322 treatment regimen in combination with daratumumab with or without lenalidomide or with pomalidomide; and for Part 2 (Dose Expansion) is to further characterize the safety and tolerability of JNJ-79635322 combination treatment regimens at selected RP2D(s).
Interventions
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JNJ-79635322
(Drug)
JNJ-79635322 will be administered subcutaneously.
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Daratumumab
(Drug)
Daratumumab will be administered subcutaneously.
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Pomalidomide
(Drug)
Pomalidomide will be administered orally.
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Lenalidomide
(Drug)
Lenalidomide will be administered orally.
Eligibility criteria
Conditions
Locations
- Colorado Blood Cancer Institute — Denver, Colorado, United States
- Winship Cancer Institute Emory University — Atlanta, Georgia, United States
- Monash Medical Centre — Clayton, Australia
- St Vincents Hospital Melbourne — Fitzroy, Australia
- Peter MacCallum Cancer Centre — Melbourne, Australia
- Calvary Mater Newcastle Hospital — Waratah, Australia
- Wollongong Hospital — Wollongong, Australia
- Carmel Medical Center — Haifa, Israel
- Hadassah Medical Center — Jerusalem, Israel
- Sheba Medical Center — Ramat Gan, Israel
- Tel Aviv Sourasky Medical Center — Tel Aviv, Israel
- VU Medisch Centrum — Amsterdam, Netherlands
- Universitair Medisch Centrum Groningen — Groningen, Netherlands
- UMC Utrecht — Utrecht, Netherlands
- Hosp. Clinic de Barcelona — Barcelona, Spain
- Hosp Clinico Univ de Salamanca — Salamanca, Spain
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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