RECRUITING Phase 3 ClinicalTrials.gov

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Sponsor: Pfizer • ClinicalTrials.gov ID: NCT06758401

Registry updated: 2026-09-25

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Description

The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control. The study is seeking for participants who: * Are confirmed to have NSCLC (Stage 3 or 4). * Have PD-L1 levels in more than 50% of the cancer cells. All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab. Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.

Interventions

Sigvotatug Vedotin (Drug)
MMAE-Antibody Drug Conjugate targeting Integrin Beta-6
Pembrolizumab (Drug)
Anti-PD-(L)1

Eligibility criteria

Inclusion Criteria: 1. Participants must meet the following criteria: 1. Have pathologically confirmed Stage IIIB or IIIC NSCLC and not be a candidate for surgical resection or definitive chemoradiation, or Stage IV NSCLC per the AJCC Staging Manual (Version 8.0) and the UICC Staging System (Eighth edition). 2. Participants with known AGAs including EGFR, ALK, ROS1, NTRK, BRAF, RET, and MET, for which there are approved and available first-line therapies per local SOC are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology. 3. Participants with large cell neuroendocrine carcinoma are excluded. 4. Must be an appropriate candidate for treatment with pembrolizumab monotherapy per local guidelines. 2. Tumor has PD-L1 expression in ≥50% of tumor cells (TPS ≥50%) as determined by local testing. 3. Measurable disease based on RECIST v1.1 per investigator. 4. Resolution of acute effects of any prior therapy to either baseline severity or NCI CTCAE Grade 1 or less (except for AEs not constituting a safety risk in the investigator's judgment), unless otherwise excluded. Exclusion Criteria: 1. Life expectancy of \<3 months in the opinion of the investigator. 2. Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study. 3. Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy. 4. Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab. 5. Participants with any of the following respiratory conditions: 1. Evidence of noninfectious or drug-induced ILD or pneumonitis 2. Known DLCO (adjusted for hemoglobin) \<50% predicted. 3. Grade ≥3 pulmonary disease unrelated to underlying malignancy 6. Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Up to 5 clinically asymptomatic brain metastases of longest diameter \<1.0 cm are permitted without definitive surgery and/or radiotherapy. 7. Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery (excluding peripherally inserted central catheter placement and implantable central venous port placement) within 3 days prior to first dose of study intervention. 8. Receipt of a live vaccine within 30 days prior to first dose of study intervention. 9. Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0. 10. Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained. 11. Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for \>2 weeks, or required treatment with systemic immunosuppressive therapy. 12. History of autoimmune disease that has required systemic treatment in the past 2 years 13. Participants with prior solid organ or bone marrow transplantation. 14. Currently receiving a high-dose steroid (\>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant. 15. Prior and concomitant therapy: 1. Any prior treatment with MMAE-derived drugs or IB6 targeting agents. 2. Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC. * (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose. * Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose. 3. Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received. This includes both curative and palliative radiotherapy. 4. Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy. 5. Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor 16. History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV. 17. Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months

Conditions

Non-Small Cell Lung Cancer Carcinoma, Non-Small-Cell Lung Carcinoma, Non-Small-Cell Lung (NSCLC)

Locations

Providence Medical Foundation — Fullerton, California, United States
Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center — Fullerton, California, United States
Providence St. Jude Medical Center — Fullerton, California, United States
St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test) — Fullerton, California, United States
Intermountain Health Cancer Center Lutheran Hospital — Golden, Colorado, United States
Cancer Centers of Colorado St. Mary's Regional Hospital — Grand Junction, Colorado, United States
Intermountain Health St. Mary's Regional Hospital — Grand Junction, Colorado, United States
Intermountain Health — Grand Junction, Colorado, United States
Intermountain Health Lutheran Hospital — Wheat Ridge, Colorado, United States
Washington DC Veterans Affairs Medical Center — Washington D.C., District of Columbia, United States
Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
BRCR Global — Plantation, Florida, United States
Endeavor Health — Elmhurst, Illinois, United States
Hope and Healing Cancer Services — Hinsdale, Illinois, United States
Advocate Medical Group - Libertyville Oncology — Libertyville, Illinois, United States
Endeavor Health — Naperville, Illinois, United States
Hope and Healing Cancer Services — New Lenox, Illinois, United States
Advocate Christ Medical Center — Oak Lawn, Illinois, United States
Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
Saint Luke's South Hospital — Overland Park, Kansas, United States
Maine Medical Center — Portland, Maine, United States
MaineHealth Cancer Care and Blood Disorders Scarborough — Scarborough, Maine, United States
MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine, United States
Southcoast Centers for Cancer Care — Fairhaven, Massachusetts, United States
Southcoast Centers for Cancer Care — Fall River, Massachusetts, United States
Corewell Health - Butterworth Hospital — Grand Rapids, Michigan, United States
Corewell Health - Lemmen Holton Cancer Pavilion — Grand Rapids, Michigan, United States
Corewell Health - Research Specimen Processing Area — Grand Rapids, Michigan, United States
Corewell Health Investigational Drug Services — Grand Rapids, Michigan, United States
Corewell Health — Grand Rapids, Michigan, United States
Minnesota Oncology Hematology, PA — Burnsville, Minnesota, United States
Minnesota Oncology Hematology PA — Coon Rapids, Minnesota, United States
M Health Fairview Cancer Clinic-Edina — Edina, Minnesota, United States
Minnesota Oncology Hematology PA — Edina, Minnesota, United States
Minnesota Oncology Hematology PA — Maple Grove, Minnesota, United States
M Health Fairview St. John's Hospital — Maplewood, Minnesota, United States
Minnesota Oncology Hematology PA — Maplewood, Minnesota, United States
Hennepin County Medical Center — Minneapolis, Minnesota, United States
North Memorial Health Cancer Center — Robbinsdale, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium (MMCORC) — Saint Louis Park, Minnesota, United States
Park Nicollet Frauenshuh Cancer Center — Saint Louis Park, Minnesota, United States
Regions Hospital — Saint Paul, Minnesota, United States
Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center — Woodbury, Minnesota, United States
Jackson Oncology Associates, PLLC — Jackson, Mississippi, United States
Jackson Oncology Associates, PLLC — Jackson, Mississippi, United States
Saint Luke's Hospital of Kansas City — Kansas City, Missouri, United States
Saint Luke's East Hospital — Lee's Summit, Missouri, United States
SCL Health - Montana — Billings, Montana, United States
SCL Health - Montana — Billings, Montana, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont — Fremont, Nebraska, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island — Grand Island, Nebraska, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional — Grand Island, Nebraska, United States
Kearney Cancer Center — Kearney, Nebraska, United States
Cancer Partners of Nebraska — Lincoln, Nebraska, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist — Omaha, Nebraska, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan — Omaha, Nebraska, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists — Omaha, Nebraska, United States
Hematology Oncology Associates of Rockland — Nyack, New York, United States
Brody School of Medicine at East Carolina University — Greenville, North Carolina, United States
ECU Health Medical Center — Greenville, North Carolina, United States
Carolina Cancer Research Center — Wilson, North Carolina, United States
University Hospitals Seidman Cancer Center at UH Avon Health Center — Avon, Ohio, United States
Gabrail Cancer Center Research — Canton, Ohio, United States
University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
University Hospitals Seidman Cancer Center at UH Mentor Health Center — Mentor, Ohio, United States
UH Minoff Health Center at Chagrin Highlands — Orange, Ohio, United States
The University of Texas, MD Anderson Cancer Center - Woodlands — Conroe, Texas, United States
Renovatio Clinical - El Paso — El Paso, Texas, United States
The University of Texas MD Anderson Cancer Center Diagnostic Imaging — Houston, Texas, United States
The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services — Houston, Texas, United States
The University of Texas, MD Anderson Cancer Center- Interventional Radiology — Houston, Texas, United States
University of Texas MD Anderson Cancer Center — Houston, Texas, United States
The University of Texas MD Anderson Cancer Center Clinical Research Imaging — Houston, Texas, United States
The University of Texas, MD Anderson Cancer Center - West Houston — Houston, Texas, United States
Community Clinical Trials — Kingwood, Texas, United States
The University of Texas, MD Anderson Cancer Center - League City — League City, Texas, United States
The University of Texas, MD Anderson Cancer Center - Sugar Land — Sugar Land, Texas, United States
Renovatio Clinical — The Woodlands, Texas, United States
Woodlands Radiology — The Woodlands, Texas, United States
American Oncology Network Vista Oncology Division-West office — Olympia, Washington, United States
American Oncology Network Vista Oncology Division-East office — Olympia, Washington, United States
Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
Aurora St. Luke's Medical Center — Milwaukee, Wisconsin, United States
Centro de Oncología e Investigación de Buenos Aires — Berazategui, Buenos Aires, Argentina
Fundación Respirar — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Centro Medico de Enfermedades Respiratorias -CEMER — Florida, Buenos Aires, Argentina
Investigaciones Oncológicas C. Colón S.A — Mar del Plata, Buenos Aires, Argentina
Centro de Investigación Pergamino — Pergamino, Buenos Aires, Argentina
Centro de Investigaciones Medicas y Desarrollo LC — Buenos Aires, Cdad. Autónoma de Buenos Aires, Argentina
Fundacion Ars Medica — San Salvador de Jujuy, Jujuy Province, Argentina
Fundacion Medica de Rio Negro y Neuquen — Cipolletti, Río Negro Province, Argentina
Fundacion Estudios Clinicos — Rosario, Santa Fe Province, Argentina
Sanatorio Británico — Rosario, Santa Fe Province, Argentina
Sanatorio Parque — Rosario, Santa Fe Province, Argentina
Hospital Provincial del Centenario — Rosario, Santa Fe Province, Argentina
Centro Oncologico Korben — Buenos Aires, Argentina
Instituto Argentino de Diagnóstico y Tratamiento (IADT) — Buenos Aires, Argentina
Centro Urológico Profesor Bengió — Córdoba, Argentina
Sanatorio Privado de la Cañada — Córdoba, Argentina
Hospital Privado Universitario de Córdoba — Córdoba, Argentina
Centro Medico Privado CEMAIC — Córdoba, Argentina
Instituto San Marcos — San Juan, Argentina
Coffs Harbour Health Campus — Coffs Harbour, New South Wales, Australia
Macquarie University — North Ryde, New South Wales, Australia
Campbelltown Hospital — Sydney, New South Wales, Australia
Sunshine Coast University Hospital — Birtinya, Queensland, Australia
Townsville University Hospital — Douglas, Queensland, Australia
Gympie Hospital — Gympie, Queensland, Australia
Nambour General Hospital — Nambour, Queensland, Australia
Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
Sir Charles Gairdner Hospital — Perth, Western Australia, Australia
Ordensklinikum Linz GmbH Elisabethinen — Linz, Upper Austria, Austria
Medizinische Universität Graz — Graz, Austria
Medizinische Universität Wien — Vienna, Austria
Klinik Floridsdorf — Vienna, Austria
AZ Sint-Maarten — Mechelen, Antwerpen, Belgium
UZ Brussel — Brussels, Bruxelles-capitale, Région de, Belgium
Grand Hôpital de Charleroi — Charleroi, Hainaut, Belgium
Algemeen Ziekenhuis klina — Brasschaat, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman — Liège, Belgium
Crio - Centro Regional Integrado de Oncologia — Fortaleza, Ceará, Brazil
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará — Fortaleza, Ceará, Brazil
Afecc Associacao Feminina Educacao Combate Cancer — Vitória, Espírito Santo, Brazil
Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael — Salvador, Estado de Bahia, Brazil
Clinica Amo - Rio Vermelho — Salvador, Estado de Bahia, Brazil
Onco-Vida - Instituto Especializado De Oncologia — Brasília, Federal District, Brazil
Hospital Erasto Gaertner — Curitiba, Paraná, Brazil
Real Hospital de Beneficência Portuguesa de Pernambuco — Recife, Pernambuco, Brazil
Vencer Centro de Pesquisa LTDA — Teresina, Piauí, Brazil
Liga Norte Riograndense Contra o Câncer — Natal, Rio Grande do Norte, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia — Ijuí, Rio Grande do Sul, Brazil
Hospital Moinhos de Vento — Porto Alegre, Rio Grande do Sul, Brazil
Hospital São Lucas da PUCRS — Porto Alegre, Rio Grande do Sul, Brazil
ANIMI - Unidade de Tratamento Oncologico — Lages, Santa Catarina, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos — Barretos, São Paulo, Brazil
Hospital Universitário São Francisco na Providência de Deus — Bragança Paulista, São Paulo, Brazil
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) — Ribeirão Preto, São Paulo, Brazil
Faculdade de Medicina do ABC — Santo André, São Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto — São José do Rio Preto, São Paulo, Brazil
Hospital Alemao Oswaldo Cruz — São Paulo, São Paulo, Brazil
Fundação Doutor Amaral Carvalho — Jaú, Brazil
Instituto D'Or de Pesquisa e Ensino — Rio de Janeiro, Brazil
Instituto D'Or de Pesquisa e Ensino — Rio de Janeiro, Brazil
Instituto D'Or de Pesquisa e Ensino — Rio de Janeiro, Brazil
Instituto D'Or de Pesquisa e Ensino — Rio de Janeiro, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo — São Paulo, Brazil
MBAL Uni Hospital — Panagyurishte, Pazardzhik, Bulgaria
Complex Oncology Center - Burgas — Burgas, Bulgaria
Medical Center Futuremeds — Plovdiv, Bulgaria
MHAT for Women's Health Nadezhda — Sofia, Bulgaria
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD — Sofia, Bulgaria
University Specialized Hospital for Active Treatment of Oncology EAD — Sofia, Bulgaria
BC Cancer Abbotsford — Abbotsford British Columbia, British Columbia, Canada
CIUSSS de l'Est-de-l'Île-de-Montréal — Montreal, Quebec, Canada
Centre de Services Ambulatoire de St-Jerome — Saint-Jérôme, Quebec, Canada
Unité de Recherche Clinique du CISSS des Laurentides — Saint-Jérôme, Quebec, Canada
Clínica Alemana Valdivia — Valdivia, Los Ríos Region, Chile
Oncocentro Valdivia — Valdivia, Los Ríos Region, Chile
Iceg Clinic — La Florida, Santiago Metropolitan, Chile
Fundación Arturo Lopéz Pérez — Providencia, Santiago Metropolitan, Chile
FALP — Providencia, Santiago Metropolitan, Chile
Fundacion Arturo Lopez Perez — Providencia, Santiago Metropolitan, Chile
Profar — Providencia, Santiago Metropolitan, Chile
Clínica Vespucio — Santiago, Santiago Metropolitan, Chile
Instituto Nacional del Cancer — Santiago, Santiago Metropolitan, Chile
Sociedad Oncovida SA — Santiago, Santiago Metropolitan, Chile
FALP — Providencia, Santiago, RM, Chile
Oncocentro Apys — Viña del Mar, Valparaiso, Chile
Anhui Provincial Cancer Hospital — Hefei, Anhui, China
Beijing Cancer hospital — Beijing, Beijing Municipality, China
Beijing Chest Hospital,Capital Medical University — Beijing, Beijing Municipality, China
Fujian Cancer Hospital — Fuzhou, Fujian, China
Nanfang Hospital of Southern Medical University — Guangzhou, Guangdong, China
Huizhou Central People's Hospital — Huizhou, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital — Nanning, Guangxi, China
Harbin Medical University Cancer Hospital — Harbin, Heilongjiang, China
The First Affiliated Hospital of Henan University of Science &Technology — Luoyang, Henan, China
Henan Cancer Hospital — Zhengzhou, Henan, China
Wuhan Union Hospital Cancer Center — Wuhan, Hubei, China
Hubei Cancer Hospital — Wuhan, Hubei, China
Hunan Cancer Hospital — Changsha, Hunan, China
The First People's Hospital of Changzhou — Changzhou, Jiangsu, China
Jiangsu Province Hospital — Nanjing, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical College — Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
Jilin Province Tumor Hospital — Changchun, Jilin, China
The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China
Jinan Central Hospital — Jinan, Shandong, China
Shandong Cancer Hospital — Jinan, Shandong, China
LinYi Cancer Hospital — Linyi, Shandong, China
Shanghai Chest Hospital — Shanghai, Shanghai Municipality, China
Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China
Sichuan Cancer hospital — Chengdu, Sichuan, China
West China Hospital, Sichuan University — Chengdu, Sichuan, China
Tianjin Medical University General Hospital — Tianjin, Tianjin Municipality, China
Yunnan Province Cancer Hospital — Kunming, Yunnan, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province — Taizhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China
Fakultni Thomayerova nemocnice — Prague, Praha 4, Czechia
Krajska nemocnice Liberec, a.s. — Liberec1, Czechia
Nemocnice AGEL Novy Jicin a.s. — Nový Jičín, Czechia
Fakultni nemocnice Olomouc — Olomouc, Czechia
Fakultni Nemocnice Motol a Homolka — Prague, Czechia
CHU Bordeaux Haut-Leveque — Pessac, Aquitaine, France
Centre Hospitalier de Cornouaille Quimper - Concarneau — Quimper, Brittany Region, France
CHU de Toulouse - Hopital Larrey — Toulouse, Haute-garonne, France
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou — Rennes, Ille-et-vilaine, France
Centre de Cancérologie du Grand Montpellier — Montpellier, Languedoc-roussillon, France
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes — Saint-Herblain, Loire-atlantique, France
Institut de Cancérologie de l'Ouest — Saint-Herblain, Loire-atlantique, France
Centre Hospitalier de Cholet — Cholet, PAYS de Loire, France
Centre Hospitalier intercommunal de Toulon La Seyne sur Hospital Sainte-Musse health establishment — Toulon, Provence-Alpes-Côte d'Azur Region, France
Centre Hospitalier Intercommunal de Créteil — Créteil, Val-de-marne, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord — Marseille, France
Centre Antoine Lacassagne — Nice, France
Hopitaux Universitaires Paris Centre-Hopital Cochin — Paris, France
Institut Curie — Paris, France
Universitaetsklinikum Ulm — Ulm, Baden-Wurttemberg, Germany
Johannes Apotheke Gröbenzell — Gröbenzell, Bavaria, Germany
Klinikum Traunstein — Traunstein, Bavaria, Germany
UKGM Gießen/Marburg — Giessen, Hesse, Germany
Klinikum Kassel — Kassel, Hesse, Germany
InVO Institut für Versorgungsforschung in der Onkologie — Koblenz, Rhineland-Palatinate, Germany
Klinikum Chemnitz gGmbH — Chemnitz, Saxony, Germany
Klinikum Chemnitz - Flemmingstraße — Chemnitz, Saxony, Germany
Krankenhaus Martha-Maria Halle-Dölau — Halle, Saxony-Anhalt, Germany
Universitätsklinikum Schleswig-Holstein — Lübeck, Schleswig-Holstein, Germany
ohO Research GmbH — Oldenburg in Holstein, Schleswig-Holstein, Germany
Zentralklinik Bad Berka GmbH — Bad Berka, Germany
Charité - Universitätsmedizin Berlin — Berlin, Germany
Charité Campus Virchow-Klinikum — Berlin, Germany
Labor Berlin — Berlin, Germany
Vivantes Humboldt Klinikum Apotheke Nord — Berlin, Germany
Vivantes Hospital Spandau — Berlin, Germany
Asklepios Klinik Gauting GmbH — Gauting, Germany
LungenClinic Grosshansdorf — Großhansdorf, Germany
Radiologie München — München, Germany
Thoracic General Hospital of Athens "I Sotiria" — Athens, Attikí, Greece
Metropolitan General Hospital — Athens, Attikí, Greece
Metropolitan Hospital — Athens, Attikí, Greece
Hygeia Hospital — Marousi, Attikí, Greece
European Interbalkan Medical Center — Thessaloniki, Thessaloníki, Greece
Errikos Dunant Hospital Center — Athens, Greece
University General Hospital of Larissa, Urology Department — Larissa, Greece
Agios Loukas Clinic — Thessaloniki, Greece
Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház — Gyula, Bekes County, Hungary
Farkasgyepui Tudogyogyintezet — Farkasgyepű, Veszprém megye, Hungary
Fejér Vármegyei Szent György Egyetemi Oktató Kórház — Székesfehérvár, Hungary
Komárom-Esztergom Vármegyei Szent Borbála Kórház — Tatabánya, Hungary
Spandana Oncology Centre (SOC) — Bengaluru, Karnataka, India
Tata Memorial Hospital — Mumbai, Maharashtra, India
Sahyadri Super Speciality Hospital — Pune, Maharashtra, India
Bhakti Vedanta Hospital and Research Institute — Thane, Maharashtra, India
Dr B. L. Kapur Memorial Hospital — New Delhi, National Capital Territory of Delhi, India
Venkateshwar Hospital — New Delhi, National Capital Territory of Delhi, India
Fortis Hospital — New Delhi, National Capital Territory of Delhi, India
AIG Hospitals — Hyderabad, Telangana, India
Shaare Zedek Medical Center — Jerusalem, Jerusalem, Israel
Clalit Health Services through Rabin Medical Center — Petah Tikva, Israel
Istituto Nazionale Tumori IRCCS Fondazione Pascale — Naples, Campania, Italy
Humanitas Istituto Clinico Catanese — Misterbianco, Catania, Italy
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" — Meldola, Emilia-Romagna, Italy
Azienda Sanitaria Territoriale Pesaro e Urbino (AST PU) — Pesaro (PU), Pesaro AND Urbino, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga — Orbassano, Piedmont, Italy
Ospedale Isola Tiberina - Gemelli Isola — Rome, ROMA, Italy
IRCCS Istituto Nazionale dei Tumori Regina Elena — Roma, ROME, Italy
Policlinico "G. Rodolico" — Catania, Sicily, Italy
Azienda Ospedaliera San Giuseppe Moscati — Avellino, Italy
Ospedale San Raffaele — Milan, Italy
Istituto Europeo di Oncologia IRCCS — Milan, Italy
Istituto Oncologico Veneto IRCCS — Padova, Italy
Ehime University Hospital — Tōon, Ehime, Japan
Kurume University Hospital — Kurume, Fukuoka, Japan
Gunma Prefectural Cancer Center — Otashi, Gunma, Japan
National Hospital Organization Asahikawa Medical Center — Asahikawa, Hokkaido, Japan
Kobe City Medical Center General Hospital — Kobe, Hyōgo, Japan
Kanagawa cancer center — Yokohama, Kanagawa, Japan
Mie Chuo Medical Center — Tsu, Mie-ken, Japan
Sendai Kousei Hospital — Sendai, Miyagi, Japan
NHO Kinki Chuo Chest Medical Center — Sakai, Osaka, Japan
The University of Osaka Hospital — Suita, Osaka, Japan
Nippon Medical School Hospital — Bunkyo-ku, Tokyo, Japan
National Cancer Center Hospital — Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital of JFCR — Koto, Tokyo, Japan
National Hospital Organization Tokyo Medical Center — Meguro-Ku, Tokyo, Japan
Yamagata University Hospital — Yamagata, Yamagata, Japan
National Hospital Organization Kyushu Medical Center — Fukuoka, Japan
National Hospital Organization Kyushu Cancer Center — Fukuoka, Japan
National Hospital Organization Kyoto Medical Center — Kyoto, Japan
National Hospital Organization Okayama Medical Center — Okayama, Japan
Osaka International Cancer Institute — Osaka, Japan
Centro de Investigación Clínica y Medicina Traslacional (CIMeT) — Guadalajara, Jalisco, Mexico
Instituto Veracruzano en Investigación Clínica S.C. — Veracruz de Ignacio de LA Llave, Veracruz, Mexico
Instituto Nacional de Cancerologia — Mexico City, Mexico
Clinica Integral Internacional de Oncología — Puebla City, Mexico
Ziekenhuis St. Jansdal — Harderwijk, Gelderland, Netherlands
Amphia Ziekenhuis, locatie Breda Molengracht — Breda, North Brabant, Netherlands
Isala, locatie Zwolle — Zwolle, Overijssel, Netherlands
Frisius Medisch Centrum — Leeuwarden, Provincie Friesland, Netherlands
St. Antonius Ziekenhuis, locatie Utrecht — Utrecht, Netherlands
Med-Polonia Sp. z o. o. — Poznan, Greater Poland Voivodeship, Poland
Instytut Genetyki i Immunologii GENIM — Lublin, Lublin Voivodeship, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie — Warsaw, Masovian Voivodeship, Poland
Uniwersyteckie Centrum Kliniczne — Gdansk, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy — Gliwice, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow — Poznan, Poland
Instytut MSF Sp zoo — Lodz, Łódź Voivodeship, Poland
SC Memorial Healthcare International SRL — Bucharest, Bucharest, Romania
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu" — Bucharest, Bucharest, Romania
Sc Mnt Healthcare Europe Srl — Bucharest, Bucharest, Romania
SC Medisprof SRL — Cluj-Napoca, Cluj, Romania
SC Radiotherapy Center Cluj SRL — Florești, Cluj, Romania
Ovidius Clinical Hospital OCH — Ovidiu, Constanța County, Romania
SC Oncolab SRL — Craiova, Dolj, Romania
Centrul de Oncologie "Sfântul Nectarie" — Craiova, Dolj, Romania
S C Oncocenter Oncologie Clinica S R L — Timișoara, Timiș County, Romania
King Saud University Medical City — Riyadh, Riyadh Region, Saudi Arabia
King Faisal Specialist Hospital and Research Center — Riyadh, Saudi Arabia
Univerzitná nemocnica Bratislava - Nemocnica Ružinov — Bratislava, Bratislava Region, Slovakia
Vychodoslovensky Onkologicky Ustav a.s. — Košice, Košice Region, Slovakia
Nemocnica AGEL Komarno — Komárno, Nitra Region, Slovakia
Fakultna nemocnica Trnava — Trnava, Trnava Region, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky — Nové Zámky, Slovakia
POKO Poprad s.r.o. — Poprad, Slovakia
Chonnam National University Hwasun Hospital — Hwasun-gun, Jeonranamdo, South Korea
Seoul National University Bundang Hospital — Seongnam, Kyǒnggi-do, South Korea
The Catholic University Of Korea St. Vincent's Hospital — Suwon, Kyǒnggi-do, South Korea
Ajou University Hospital — Suwon, Kyǒnggi-do, South Korea
Pusan National University Hospital — Busan, Pusan-kwangyǒkshi, South Korea
Inje University Haeundae Paik Hospital — Haeundae-gu, Pusan-kwangyǒkshi, South Korea
Severance Hospital, Yonsei University Health System — Seoul, Seoul-teukbyeolsi [seoul], South Korea
Boramae Medical Center — Seoul, Seoul-teukbyeolsi [seoul], South Korea
Korea University Guro Hospital — Seoul, Seoul-teukbyeolsi [seoul], South Korea
Kyungpook National University Chilgok Hospital — Deagu, Taegu-kwangyǒkshi, South Korea
CHUAC-Complejo Hospitalario Universitario A Coruña — A Coruña, A Coruña [LA Coruña], Spain
Hospital General Universitario de Elche — Elche, Alicante, Spain
Hospital Universitari Dexeus — Barcelona, Barcelona [barcelona], Spain
Hospital Universitari Vall D Hebron — Barcelona, Barcelona/spain, Spain
Hospital de la Santa Creu i Sant Pau — Barcelona, Catalunya [cataluña], Spain
Institut Català d'Oncologia - L'Hospitalet — L'Hospitalet de Llobregat, Catalunya [cataluña], Spain
Hospital Jerez de la Frontera — Jerez de la Frontera, Cádiz, Spain
Hospital Son Llàtzer — Palma, Illes Balears [islas Baleares], Spain
Hospital Universitario 12 de Octubre — Madrid, Madrid, Comunidad de, Spain
Hospital Clinico de Valencia — Valencia, Valenciana, Comunitat, Spain
Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR") — Barcelona, Spain
Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO" — Barcelona, Spain
Complejo Hospitalario Universitario Insular Materno-Infantil — Las Palmas de Gran Canaria, Spain
FutureMeds - Madrid — Madrid, Spain
Hospital General Universitario Gregorio Marañon — Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz — Madrid, Spain
Hospital Quirón Málaga — Málaga, Spain
Hospital Universitario Virgen Del Rocio — Seville, Spain
Inselspital Bern — Bern, Canton of Bern, Switzerland
UniversitätsSpital Zürich — Zurich, Switzerland
Chi Mei Hospital - Liouying Branch — Tainan, Tainan, Taiwan
National Taiwan University Cancer Center (NTUCC) — Taipei City, Taipei, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
Chang Gung Memorial Hospital at Kaohsiung — Kaohsiung City, Taiwan
Taichung Veterans General Hospital — Taichung, Taiwan
National Cheng Kung University Hospital — Tainan, Taiwan
National Taiwan University Hospital — Taipei, Taiwan
Taipei Veterans General Hospital — Taipei, Taiwan
Medipol Mega Universite Hastanesi — Istanbul, İ̇stanbul, Turkey (Türkiye)
İ.A.Ü VM Medical Park Florya Hastanesi — Istanbul, İ̇stanbul, Turkey (Türkiye)
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi — Istanbul, İ̇stanbul, Turkey (Türkiye)
Ege Universitesi Hastanesi — Izmir, İ̇zmir, Turkey (Türkiye)
İzmir Suat Seren Chest Disease Training & Research Hospital — Izmir, İ̇zmir, Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals — Ankara, Turkey, Turkey (Türkiye)
Adana Medical Park Seyhan Hastanesi — Adana, Turkey (Türkiye)
Gulhane Egitim Arastirma Hastanesi — Ankara, Turkey (Türkiye)
Hacettepe Universite Hastaneleri — Ankara, Turkey (Türkiye)
Memorial Ankara Hastanesi — Ankara, Turkey (Türkiye)
Gazi University Health Research and Application Center Gazi Hospital — Ankara, Turkey (Türkiye)
Liv Hospital Ankara — Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi — Ankara, Turkey (Türkiye)
Antalya Egitim ve Arastırma Hastanesi — Antalya, Turkey (Türkiye)
Dicle Üniversitesi — Diyarbakır, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa — İstanbul - Fatih, Turkey (Türkiye)
Royal Cornwall Hospitals NHS Trust — Truro, Carnwall, United Kingdom
Weston Park Hospital — Sheffield, England, United Kingdom
University Hospital Southampton NHS Foundation Trust — Southampton, Hampshire, United Kingdom
Mount Vernon Hospital — Northwood, Hillingdon, United Kingdom
St Bartholomew's Hospital — London, London, CITY of, United Kingdom
Musgrove Park Hospital — Taunton, Somerset, United Kingdom
Ipswich Hospital — Ipswich, Suffolk, United Kingdom
The Christie NHS Foundation Trust — Manchester, United Kingdom
Royal Berkshire Hospital — Reading, United Kingdom

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