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RECRUITING Not applicable ClinicalTrials.gov

Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

Sponsor: Brigham and Women's Hospital • ClinicalTrials.gov ID: NCT06743659

Registry updated: 2026-09-29
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Description

The goal of this clinical trial is to learn if a computer alert can aid clinicians in identifying patients with a genetic type of high cholesterol, called Familial Hypercholesterolemia. The main question it aims to answer is whether the computer alert increases recognition of this high cholesterol disorder.

Interventions

  • Alert-based computerized decision support (Device)
    A program will be designed to run within the Electronic Health Record (EHR) that will identify outpatients with "definite," "probable," or "possible" diagnosis of FH. The BPA will calculate the Dutch Lipid Clinic Network score using the following EHR data: 1. Maximum LDL-C level in the laboratory results 2. Abnormal genetic testing for FH in the laboratory results 3. Medical history or problem list entry for tendinous xanthomata or arcus cornealis 4. Medical history, visit diagnosis, or problem list entry of premature CAD, cerebrovascular disease, or PAD 5. Family history of premature CAD, cerebrovascular disease, or PAD In the Alert phase, an on-screen alert will notify the ambulatory care clinician of record that the patient has a "definite," "probable," or "possible" diagnosis of FH. ambulatory care clinician will have the opportunity to proceed to an order template through which a referral for specialty care focused on evaluation and management of FH can be made.

Eligibility criteria

Inclusion Criteria: * ≥ 18 years old * seen in the BWH Endocrinology, Cardiovascular Medicine, and Primary Care Clinics * Dutch Lipid Clinic Network score of at least 3 points Exclusion Criteria: * a Familial Hypercholesterolemia diagnosis already documented in the EHR medical history, visit history, or problem list

Conditions

Familial Hypercholesterolaemia

Locations

  • Brigham and Women's Hospital — Boston, Massachusetts, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record