RECRUITING Phase 2 / Phase 3 ClinicalTrials.gov

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer (ROSETTA Lung-02)

Sponsor: BioNTech SE • ClinicalTrials.gov ID: NCT06712316

Registry updated: 2026-10-15

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Description

This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC). This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC.

Interventions

Pumitamig (Drug)
Intravenous infusion
Pembrolizumab (Drug)
Intravenous infusion
Carboplatin (Drug)
Intravenous infusion
Pemetrexed (Drug)
Intravenous infusion
Paclitaxel (Drug)
Intravenous infusion

Eligibility criteria

Key Inclusion Criteria: * Have systemic treatment naive, histologically or cytologically confirmed diagnosis of Stage IIIB or IIIC (who are not amenable to curative surgery or radiotherapy) or Stage IV NSCLC per the Union Internationale contre le Cancer/American Joint Committee on Cancer staging system, 9th edition. * Have at least one measurable lesion as the targeted lesion based on RECIST v1.1. Lesions treated after prior local treatment (radiotherapy, ablation, interventional procedures, etc.) are generally not considered as target lesions. If the lesion with prior local treatment is the only targeted lesion, evidence-based radiology must be provided to demonstrate disease progression (the single bone metastasis or the single central nervous system metastasis should not be considered as a measurable lesion). * Eastern Cooperative Oncology Group Performance Status of 0 or 1. * Adequate organ function as defined in the protocol. Key Exclusion Criteria: * Have histologically or cytologically confirmed NSCLC with small-cell lung cancer or neuroendocrine histologic component. * Have received any of the following therapies or drugs within the noted time intervals prior to study treatment: * Previous chemotherapy (platinum-based) or PD(L)-1 for treating NSCLC in either neoadjuvant/adjuvant or locally advanced/metastatic setting. * Participants who received prior treatment with anti-VEGF monoclonal antibody, or PD(L)-1/VEGF bispecific antibody. * Have received systemic corticosteroids (at a dosage greater than 10 mg/day of prednisone or an equivalent dose of other corticosteroids) within 7 days prior to the initiation of study treatment. Note: local, intranasal, intraocular, intra-articular or inhaled corticosteroids, short-term use (\<=7 days) of corticosteroids for prophylaxis (e.g., prevention of contrast agent allergy) or treatment of non-autoimmune conditions (e.g., delayed hypersensitivity reactions caused by exposure to allergens) are allowed. * Have uncontrolled hypertension or poorly controlled diabetic conditions prior to study treatment. * Have a serious or non-healing wound, or (incompletely healed) bone fracture. This includes history (within 6 months prior to study entry) or risk of abdominal fistula, tracheoesophageal fistula, gastrointestinal perforation, or intra-abdominal abscess or esophageal and gastric varices. In addition, the participant must have undergone correction (or spontaneous healing) of the perforation/fistula and/or the underlying process causing fistula/perforation. * Participants with significant risk of hemorrhage (per investigator clinical judgment). * Participants have superior vena cava syndrome or symptoms of spinal cord compression. NOTE: Other protocol defined Inclusion/Exclusion criteria apply.

Conditions

Non-small Cell Lung Cancer

Locations

Birmingham Hematology and Oncology Associates LLC d/b/a Alabama Oncology — Birmingham, Alabama, United States
Alaska Oncology and Hematology, LLC — Anchorage, Alaska, United States
John Muir Clinical Research Center — Concord, California, United States
University Of California - San Diego Moores Cancer Center — La Jolla, California, United States
Vail Health — Vail, Colorado, United States
MedStar Georgetown-MedStar Georgetown Transplant Institute University Hospital (MGUH) — Washington D.C., District of Columbia, United States
MEDSTAR Washington Hospital Center (MedStar Health Research Institute) — Washington D.C., District of Columbia, United States
Clermont Oncology Center — Clermont, Florida, United States
SSAK Partners, LLC. — Coral Springs, Florida, United States
Baptist Medical Center Jacksonville — Jacksonville, Florida, United States
Mid Florida Cancer Centers — Orange City, Florida, United States
Cleveland Clinic Florida - Martin North Hospital — Stuart, Florida, United States
H. Lee Moffit Cancer center and research institute — Tampa, Florida, United States
Cleveland Clinic Weston Hospital — Weston, Florida, United States
Northwest Georgia Oncology Centers, P.C. — Marietta, Georgia, United States
Fort Wayne Medical Oncology and Hematology, Inc. — Fort Wayne, Indiana, United States
Indiana University Health University Hospital — Indianapolis, Indiana, United States
Physicians Clinic of Iowa — Cedar Rapids, Iowa, United States
Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
Baptist Health Hardin — Elizabethtown, Kentucky, United States
Baptist Health Lexington — Lexington, Kentucky, United States
University of Kentucky Chandler Medical Center (UKCMC) - Markey Cancer Center (Lucille P. Markey Cancer Center) — Lexington, Kentucky, United States
Frederick Health Hospital- James M Stockman Cancer Institute — Frederick, Maryland, United States
Missouri Cancer Associates — Columbia, Missouri, United States
SSM Health Cancer Care - St. Clare — Fenton, Missouri, United States
Mary Lanning Healthcare (MLH) - Morrison Cancer Center (MCC) — Hastings, Nebraska, United States
Astera Cancer Care — East Brunswick, New Jersey, United States
Summit Medical Group PA — Florham Park, New Jersey, United States
The Valley Hospital - Valley Health System - The Robert and Audrey Luckow Pavilion — Paramus, New Jersey, United States
Nuvance Health — Poughkeepsie, New York, United States
Suny-Stony Brook University Cancer Center — Stony Brook, New York, United States
White Plains Hospital — White Plains, New York, United States
Fletcher Hospital, Inc. dba AdventHealth Hendersonville — Hendersonville, North Carolina, United States
Gabrail Cancer Center Research — Canton, Ohio, United States
The Christ Hospital Cancer Center — Cincinnati, Ohio, United States
University of Cincinnati Medical Center — Cincinnati, Ohio, United States
The Cleveland Clinic Cancer Center At Fairview Hospital, Moll Pavilion — Cleveland, Ohio, United States
Cleveland Clinic — Cleveland, Ohio, United States
Dayton Physicians Network — Dayton, Ohio, United States
Kettering Medical Center — Kettering, Ohio, United States
Cleveland Clinic - Hillcrest Hospital — Mayfield Heights, Ohio, United States
INTEGRIS Cancer Institute of Oklahoma — Oklahoma City, Oklahoma, United States
University of Tennessee Medical Center — Knoxville, Tennessee, United States
Baptist Cancer Center — Memphis, Tennessee, United States
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center — Nashville, Tennessee, United States
Millennium Research and Clinical Development, LLC — Houston, Texas, United States
Utah Cancer Specialists — Salt Lake City, Utah, United States
Virginia Cancer Specialists - Arlington — Arlington, Virginia, United States
Virginia Cancer Specialists — Fairfax, Virginia, United States
VCU Massey Cancer Center — Richmond, Virginia, United States
Shenandoah Oncology — Winchester, Virginia, United States
West Virginia University Hospitals - Mary Babb Randolph Cancer Center — Morgantown, West Virginia, United States
Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
Centro de Investigaciones Medicas y Desarrollo LC S.R.L. (LC Investigacion) — Buenos Aires, Argentina
Instituto Argentino de Diagnóstico y Tratamiento (IADT) — Buenos Aires, Argentina
Hospital Italiano de Buenos Aires — Buenos Aires, Argentina
Sanatorio Allende — Córdoba, Argentina
Centro Oncologico Riojano Integral (CORI) — La Rioja, Argentina
Exelsus SRL — San Miguel de Tucumán, Argentina
Centro de Investigaciones Clinicas. Clinica Viedma S. A — Viedma, Argentina
Cancer Research SA (CRSA) — Adelaide, Australia
Royal Adelaide Hospital — Adelaide, Australia
Flinders Medical Centre — Bedford Park, Australia
Cairns Hospital — Cairns, Australia
Dubbo Hospital — Dubbo, Australia
Peninsula & South Eastern Haematology and Oncology Group — Frankston, Australia
Joondalup Health campus — Joondalup, Australia
Icon Cancer Centre Kurralta Park — Kurralta Park, Australia
Peter MacCallum Cancer Centre — Melbourne, Australia
Monash University - Monash Health -Monash Medical Centre — Melbourne, Australia
Central West Cancer Care Centre — Orange, Australia
Clinical Trial Center-Tasman Oncology Research Ltd — Southport, Australia
Western Health Sunshine Hospital — St Albans, Australia
ICON Cancer Care - Townsville — Townsville, Australia
Cancer Care Wollongong Pty Limited — Wollongong, Australia
Universitair Ziekenhuis Gent (Uz Gent) — Ghent, Belgium
Universitair Ziekenhuis Leuven — Leuven, Belgium
CHU HELORA, Hopital de Mons - Site Kennedy — Mons, Belgium
Algemeen Ziekenhuis Delta — Roeselare, Belgium
VITAZ — Sint-Niklaas, Belgium
Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc — Woluwe-Saint-Lambert, Belgium
Fundacao Pio XII - Hospital de Cancer de Barretos — Barretos, Brazil
CIONC - Centro Integrado de Oncologia de Curitiba — Curitiba, Brazil
Centro Regional Integrado de Oncologia — Fortaleza, Brazil
Oncosite Centro De Pesquisa Clinica Em Oncologia — Ijuí, Brazil
Clinica de Neoplasias Litoral LTDA / Catarina Pesquisa Clínica — Itajaí, Brazil
Bruno Born Hospital — Lajeado, Brazil
Instituto de Cancer de Londrina - Hospital do Cancer de Londrina - HCL — Londrina, Brazil
Liga Norte Riograndense Contra o Cancer - CECAN — Natal, Brazil
Hospital Sao Vicente de Paulo (HSVP) — Passo Fundo, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre — Porto Alegre, Brazil
Centro Gaucho Integrado de Oncologia e Hematologia - Hospital Mae de Deus/AESC — Porto Alegre, Brazil
Centro Clinico do Hospital Sao Lucas da PUCRS — Porto Alegre, Brazil
Hospital Nossa Senhora da Conceicao — Porto Alegre, Brazil
Oncoclinicas Rio de Janeiro S.A (Centro de Tratamento de Tumores Botafogo) — Rio de Janeiro, Brazil
OC Oncoclínicas - Núcleo de Oncologia da Bahia-Ondina (OC Oncoclinicas-NOB Ondina) — Salvador, Brazil
CEON Pesquisas — São Caetano do Sul, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto - Hospital de Base de Sao Jose do Rio Preto — São José do Vale do Rio Preto, Brazil
IEP Sao Lucas Instituto de Ensino e Pesquisa Sao Lucas — São Paulo, Brazil
IEP São Lucas — São Paulo, Brazil
Associacao Feminina de Educacao e Combate ao Cancer(AFECC) - Hospital Santa Rita — Vitória, Brazil
Complex Oncology Center — Plovdiv, Bulgaria
Complex Oncological Center Ruse Ltd — Rousse, Bulgaria
MHAT for Womens Health - Nadezhda OOD — Sofia, Bulgaria
University Hospital Tsaritsa Yoanna - Isul (University Hospital Queen Giovanna) — Sofia, Bulgaria
Bradford Hill Norte — Antofagasta, Chile
Clinica MEDS — Lo Barnechea, Chile
Centro De Investigacion Clinica Bradford Hill — Recoleta, Chile
Orlandi Oncologia — Santiago, Chile
Centro de Estudios Clinicos e Investigaciones Medicas (CECIM) — Santiago, Chile
Affiliated Hospital of Hebei University — Baoding, China
Beijing Friendship Hospital, Capital Medical University — Beijing, China
Beijing Hospital — Beijing, China
Peking Union Medical College Hospital — Beijing, China
Beijing Chest Hospital,Capital Medical University — Beijing, China
The First Affiliated Hospital Of Bengbu Medical College — Bengbu, China
Jilin Cancer Hospital — Changchun, China
Hunan Cancer Hospital — Changsha, China
The Third Xiangya Hospital of Central South University — Changsha, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine — Hangzhou, China
Zhejiang Medical University, Zhejiang Cancer Hospital — Hangzhou, China
Jiamusi Cancer Hospital — Jiamusi, China
Shandong University - Jinan Central Hospital — Jinan, China
Yunnan Provincial Cancer Hospital — Kunming, China
Jiangsu Peoples Hospital — Nanjing, China
Shanghai Chest Hospital — Shanghai, China
Fudan University - Shanghai Cancer Center (FUSCC) — Shanghai, China
Shanghai Pulmonary Hospital — Shanghai, China
Cancer Hospital of Shantou University Medical College — Shantou, China
The First Affiliated Hospital of Soochow University — Suzhou, China
Chongqing University Three Gorges Hospital — Wanzhou, China
Zhongnan Hospital of Wuhan University — Wuhan, China
Northern Jiangsu Peoples Hospital (NJPH) — Yangzhou, China
Taizhou Hospital of Zhejiang Province — Zhejiang, China
Institut de Cancerologie de l'Ouest Paul Papin — Angers, France
Centre Hospitalier Universitaire d'Angers (CHU Angers) — Angers, France
Centre Hospitalier de la Cote Basque — Bayonne, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Saint - Andre — Bordeaux, France
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest — Bordeaux, France
Hospices Civils de Lyon - Hopital Louis Pradel — Bron, France
CHU Caen Normandie — Caen, France
Centre Francois Baclesse — Caen, France
Centre Hospitalier Universitaire de Clermont Ferrand - Gabriel Montpied — Clermont-Ferrand, France
Centre Hospitalier Intercommunal de Creteil (CHIC) - Centre de ressources et de competences pour la mucoviscidose (C.R.C.M.) — Créteil, France
Centre Hospitalier Universitaire De Grenoble- Hopital Albert Michallon — La Tronche, France
Centre Hospitalier Universitaire (CHU) De Limoges Hopital Dupuytren — Limoges, France
Hospices Civils de Lyon (HCL) - Hopital de la Croix-Rousse — Lyon, France
Institut Paoli-Calmettes — Marseille, France
GHRMSA Hopital Emile Muller — Mulhouse, France
Institut Curie - Centre de Recherche — Paris, France
Groupe Hospitalier Pitie-Salpetriere — Paris, France
CIC Cochin Pasteur, Hopital Cochin — Paris, France
Hopital Lyon Sud — Pierre-Bénite, France
CHU de Rennes, Hopital de Pontchaillou — Rennes, France
Institut de Cancerologie de l'Ouest (ICO)- CRLCC Rene Gauducheau — Saint-Herblain, France
Centre Regional Lutte Contre Le Cancer Paul Strauss — Strasbourg, France
Hopital Foch — Suresnes, France
Centre Hospitalier Intercommunal Toulon La Seyne Sur Mer (C.H.I.T.S) - Hospital Font-Pre — Toulon, France
Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP — Villejuif, France
High Technology Hospital Medcenter LTD — Batumi, Georgia
LLC Todua Clinic — Tbilisi, Georgia
LTD Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic — Tbilisi, Georgia
New Hospitals — Tbilisi, Georgia
Cancer Research Centre — Tbilisi, Georgia
Uniklinik RWTH Aachen Medizinische Klinik IV — Aachen, Germany
Evangelische Lungenklinik Berlin — Berlin, Germany
Klinikum Chemnitz gGmbH — Chemnitz, Germany
Kaiserwerther Diakonie - Florence Nightingale Krankenhaus — Düsseldorf, Germany
Universitätsklinikum Erlangen — Erlangen, Germany
Klinikum Esslingen GmbH — Esslingen am Neckar, Germany
Asklepios Fachkliniken Muenchen Gauting — Gauting, Germany
SRH Wald-Kliniken Gera GmbH — Gera, Germany
Asklepios Klinik Harburg — Hamburg, Germany
Thoraxklinik-Heidelberg Ggmbh — Heidelberg, Germany
Lungenfachklinik Immenhausen - Pneumologische Lehrklinik der Universitaet Goettingen — Immenhausen, Germany
University Medical Center of Johannes Gutenberg-University Mainz — Mainz, Germany
Krankenhaus Bethanien Moers — Moers, Germany
Staedtisches Klinikum Muenchen Bogenhausen — München, Germany
MVZ for oncology and hematology Rhein-Kreis Neuss GmbH — Neuss, Germany
Onkologische Tagesklinik Remscheid — Remscheid, Germany
Praxiskooperation Bonn-Euskirchen-Rheinbach-Wesseling — Wesseling, Germany
Helios Klinikum Wuppertal-Universitaet Witten-Herdecke — Wuppertal, Germany
Orszagos Onkologiai Intezet (National Institute of Oncology) — Budapest, Hungary
Budapesti Uzsoki Utcai Korhaz — Budapest, Hungary
Edelenyi Koch Robert Korhaz es Rendelointezet — Edelény, Hungary
Bacs- Kiskun Varmegyei Oktatokorhaz Onkoradiologiai Kozpont — Kecskemét, Hungary
Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointézet — Szolnok, Hungary
Azienda Ospedaliera San Giuseppe Moscati — Avellino, Italy
Centro di Riferimento Oncologico — Aviano, Italy
Azienda Ospedaliero Universitaria Di Bologna Policlinico S. Orsola Malpighi — Bologna, Italy
Istituto Candiolo IRCCS — Candiolo, Italy
Humanitas Istituto Clinico Catanese S.p.A — Catania, Italy
Azienda Ospedaliero - Universitaria di Ferrara — Cona, Italy
Azienda Socio Sanitaria Territoriale di Cremona (ASST Cremona) — Cremona, Italy
Ospedale San Luca — Lucca, Italy
IRCCS Istituto Romagnolo per lo studio dei Tumori Dino Amadori (IRST) — Meldola, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario San Raffaele) — Milan, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori — Milan, Italy
UOC Oncoematologia AOU Luigi Vanvitelli — Naples, Italy
Casa Di Cura Polispecialistica Dott Pederzoli — Peschiera del Garda, Italy
Fondazione Policlinico Universitario Campus Bio-Medico — Roma, Italy
Istituti di Ricovero e Cura A Carattere Scientifico (IRCCS) - Istituti Fisioterapici Ospitalieri (IFO) - Istituto Nazionale Tumori Regina Elena (IRE) — Roma, Italy
Fondazione Ospedale Isola Tiberina - Gemelli Isola — Rome, Italy
Universita di Siena -Azienda Ospedaliera Universitaria Senese-Policlincio Santa Maria Alle Scotte — Siena, Italy
Ageo Central General Hospital — Ageo, Japan
Hyogo Cancer Center — Akashi, Japan
Aomori Prefectural Central Hospital — Aomori, Japan
Tokyo Metropolitan Komagome Hospital — Bunkyō City, Japan
Hamamatsu University Hospital — Chūōku, Japan
Funabashi Municipal Medical Center — Funabashi, Japan
National Hospital Organization Himeji Medical Center — Himeji, Japan
Hiroshima Prefectural Hospital — Hiroshima, Japan
Hiroshima University Hospital — Hiroshima, Japan
Aso Iizuka Hospital — Iizuka, Japan
National Hospital Organization Iwakuni Clinical Center — Iwakuni, Japan
Shonan Kamakura General Hospital — Kanagawa, Japan
Ishikawa Prefectural Central Hospital — Kanazawa, Japan
Social Welfare Organization Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital — Kumamoto, Japan
Kurashiki Central Hospital — Kurashiki, Japan
Kurume University Hospital — Kurume, Japan
Matsusaka Municipal Hospital — Matsusaka, Japan
National Hospital Organization Shikoku Cancer Center — Matsuyama, Japan
National Hospital Organization Tokyo Medical Center — Meguro City, Japan
Dokkyo Medical University Hospital — Mibu, Japan
Iwate Medical University Hospital — Morioka, Japan
Shizuoka Cancer Center — Nagaizumi-chō, Japan
Nagasaki University Hospital — Nagasaki, Japan
Japan Community Healthcare Organization Chukyo Hospital — Nagoya, Japan
National Hospital Organization Nagoya Medical Center — Nagoya, Japan
Nagoya University Hospital — Nagoya, Japan
Niigata Cancer Center Hospital — Niigata, Japan
Hyogo Medical University Hospital — Nishinomiya, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute — Osaka, Japan
Saitama Prefectural Cancer Center — Saitama, Japan
NHO Kinki Chuo Chest Medical Center — Sakai, Japan
Teine Keijinkai Hospital — Sapporo, Japan
Sapporo Minamisanjo Hospital — Sapporo, Japan
Sendai Kousei Hospital — Sendai, Japan
Shibukawa Medical Center — Shibukawa, Japan
Toyama University Hospital — Toyama, Japan
Wakayama Medical University Hospital — Wakayama, Japan
Yokohama Municipal Citizen's Hospital — Yokohama, Japan
Uniwersytecki Szpital Kliniczny w Bialymstoku — Bialystok, Poland
In- Vivo Sp. z o. o. — Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne (UCK) - Klinika Onkologii i Radioterapii — Gdansk, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy Oddzial w Gliwicach — Gliwice, Poland
Katowickie Centrum Onkologii — Katowice, Poland
SPZOZ - Swietokrzyskie Centrum Onkologii — Kielce, Poland
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie — Koszalin, Poland
FutureMeds Krakow — Krakow, Poland
Instytut MSF Sp. z o.o. — Lodz, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi — Lodz, Poland
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie — Lublin, Poland
Warminsko Mazurskie Centrum Chorob Pluc w Olsztynie — Olsztyn, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii — Poznan, Poland
NZOZ Medpolonia Sp. Z o.o. — Poznan, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu — Przemyśl, Poland
Narodowy Insytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy — Warsaw, Poland
Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy — Warsaw, Poland
Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii — Wroclaw, Poland
Coltea Clinical Hospital — Bucharest, Romania
SC Gral Medical SRL — Bucharest, Romania
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti (IOB) — Bucharest, Romania
Cardiomed — Cluj-Napoca, Romania
Oncology Institute Cluj-Napoca — Cluj-Napoca, Romania
S.C. Medisprof S.R.L, Oncologie medicala — Cluj-Napoca, Romania
Radiotherapy Center Cluj — Cluj-Napoca, Romania
Onco Clinic Consult SA — Craiova, Romania
Centrul de Oncologie Sf. Nectarie S.R.L (Sf Nectarie Oncology Center) — Craiova, Romania
Centrul de Oncologie Euroclinic srl — Iași, Romania
Institutul Regional De Oncologie Iasi — Iași, Romania
Ovidius Clinical Hospital — Ovidiu, Romania
Municipal Hospital Ploiesti — Ploieşti, Romania
Oncomed — Timișoara, Romania
Chungbuk National University Hospital — Cheongju-si, South Korea
Chungnam National University Hospital (CNUH) — Daejeon, South Korea
National Cancer Center — Goyang-si, South Korea
Gachon University Gil Medical Center — Incheon, South Korea
Gyeongsang National University Hospital (GNUH) — Jinju, South Korea
Seoul National University Bundang Hospital (SNUBH) — Seongnam-si, South Korea
Severance Hospital, Yonsei University Health System — Seoul, South Korea
Asan Medical Center (AMC) — Seoul, South Korea
Samsung Medical Center — Seoul, South Korea
Korea University Guro Hospital — Seoul, South Korea
The Catholic University Of Korea, St. Vincent's Hospital — Suwon, South Korea
Ajou University Hospital — Suwon, South Korea
CHUAC Hospital Teresa Herrera — A Coruña, Spain
Hospital Universitario de Badajoz — Badajoz, Spain
Institut Catala d'Oncologia Badalona, Hospital Germans Trias I Pujol — Badalona, Spain
Hospital Universitario Vall d'Hebron — Barcelona, Spain
Instituto Catalan de Oncologia - Hospital Duran i Reynals — Barcelona, Spain
Consorcio Hospitalario Provincial de Castellón — Castellon, Spain
Complejo Hospitalario Universitario Insular Materno Infantil — Las Palmas de Gran Canaria, Spain
Hospital Universitario De Leon — León, Spain
Hospital Universitari de Lleida Arnau de Villanova — Lleida, Spain
Hospital General Universitario Gregorio Maranon (HGUGM) — Madrid, Spain
Clinica MD Anderson International — Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz — Madrid, Spain
Hospital Universitario 12 de Octubre — Madrid, Spain
Hospital Universitario Puerta de Hierro de Majadahonda — Majadahonda, Spain
Hospital Universitario de Canarias — Santa Cruz de Tenerife, Spain
Hospital Universitario Virgen del Rocio — Seville, Spain
Hospital Universitario Nuestra Senora De Valme — Seville, Spain
Fundacion Instituto Valenciano de Oncologia — Valencia, Spain
Hospital General Universitario De Valencia — Valencia, Spain
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur) — Valencia, Spain
Hospital Alvaro Cunqueiro — Vigo, Spain
Hospital Universitario Miguel Servet de Zaragoza — Zaragoza, Spain
Kantonspital Baden — Baden, Switzerland
Centre Hospitalier Universitaire Vaudois Lausanne (CHUV) - Centre de transplantation d'organes (CTO) — Lausanne, Switzerland
Kantonsspital Münsterlingen — Münsterlingen, Switzerland
Faculty of Medicine Vajira Hospital, Navamindradhiraj University — Bangkok, Thailand
Chulalongkorn University — Bangkok, Thailand
Chiangrai Prachanukroh Hospital — Chiang Rai, Thailand
Lampang Cancer Hospital — Lampang, Thailand
HRH Princess MahaChakri Sirindhorn Medical Center - Srinakharinwirot University — Nakhon Nayok, Thailand
Rajavithi Hospital — Ratchathewi, Thailand
Baskent Universitesi Tip Fakultesi Adana Hastanesi — Adana, Turkey (Türkiye)
Adana City Training and Research Hospital — Adana, Turkey (Türkiye)
Gulhane Training and Research Hospital — Ankara, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital — Ankara, Turkey (Türkiye)
Hacettepe University Medicine Faculty — Ankara, Turkey (Türkiye)
Memorial Ankara Hospital — Ankara, Turkey (Türkiye)
Liv Hospital Ankara — Ankara, Turkey (Türkiye)
Ankara Bilkent City Hospital — Ankara, Turkey (Türkiye)
Akdeniz University Hospital — Antalya, Turkey (Türkiye)
Dicle University Faculty of Medicine Hospital — Diyarbakır, Turkey (Türkiye)
Gaziantep Sanko University Medical Faculty — Gaziantep, Turkey (Türkiye)
Bezmialem Foundation University Medical Faculty — Istanbul, Turkey (Türkiye)
Istinye University Bahcesehir Liv Hospital — Istanbul, Turkey (Türkiye)
Yeditepe University Kosuyolu Hospital — Istanbul, Turkey (Türkiye)
Medical Point Izmir Hospital — Izmir, Turkey (Türkiye)
Goztepe Prof. Dr. Suleyman Yalcin City Hospital — Kadıköy, Turkey (Türkiye)
Ankara Ataturk Sanatoryum Saglik Uygulama ve Arastirma Merkezi — Keçiören, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi — Kocaeli, Turkey (Türkiye)
Necmettin Erbakan University Meram Medical Faculty — Konya, Turkey (Türkiye)
Medical Park Florya Hospital — Küçükçekmece, Turkey (Türkiye)
Medicalpark Ordu Hospital — Ordu, Turkey (Türkiye)
Karadeniz Technical University Faculty of Medicine — Ortahisar, Turkey (Türkiye)
Sakarya University - Faculty of Medicine — Sakarya, Turkey (Türkiye)
Ondokuz Mayis University Health Practice and Research Hospital — Samsun, Turkey (Türkiye)
Acibadem Adana Hospital — Seyhan, Turkey (Türkiye)
Medical Park Seyhan Hospital — Seyhan, Turkey (Türkiye)
Mersin City Training and Research Hospital — Toroslar, Turkey (Türkiye)
Gazi University Faculty of Medicine — Yenimahalle, Turkey (Türkiye)
Koc Universitesi Hastanesi (Koc University Hospital) — Zeytinburnu, Turkey (Türkiye)
Basildon University Hospital - Basildon And Thurrock University Hospitals Nhs Foundation Trust — Basildon, United Kingdom
Royal United Hospital, Bath - Royal United Hospitals Bath NHS Foundation Trust — Bath, United Kingdom
Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust — Brighton, United Kingdom
Velindre NHS Trust, Velindre Cancer Centre — Cardiff, United Kingdom
Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust — Chelsea, United Kingdom
Hull University Teaching Hospitals NHS Trust — Cottingham, United Kingdom
Beatson West of Scotland Cancer Centre - Greater Glasgow Health Board — Glasgow, United Kingdom
Clatterbridge Cancer Centre — Liverpool, United Kingdom
University College Hospital — London, United Kingdom
Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust — London, United Kingdom
The Christie NHS Foundation Trust — Manchester, United Kingdom
Norfolk and Norwich University Hospital - Norfolk and Norwich University Hospitals NHS Foundation Trust — Norwich, United Kingdom
Cancer And Haematology Centre-The Churchill Hospital-Oxford University Hospitals — Oxford, United Kingdom
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust — Preston, United Kingdom
Weston Park Hospital - Sheffield Teaching Hospitals NHS Foundation Trust — Sheffield, United Kingdom
Southampton General Hospital — Southampton, United Kingdom
Musgrove Park Hospital-Taunton & Somerset NHS Foundation Trust — Taunton, United Kingdom
New Cross Hospital — Wolverhampton, United Kingdom
York Teaching Hospital NHS Foundation Trust - The York Hospital — York, United Kingdom

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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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