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RECRUITING Not applicable ClinicalTrials.gov

How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

Sponsor: George Washington University • ClinicalTrials.gov ID: NCT06691100

Registry updated: 2026-09-09
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Description

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Interventions

  • Aerobic Exercise (Behavioral)
    30-minute exercise bout in a cycle ergometer at 60 to 70% of the Heart Rate Reserve (HRR) and corresponding power (watts).

Eligibility criteria

Inclusion Criteria: * Biological sex: female * BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2 * Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer) * Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity). Exclusion Criteria: * Biological sex: male * BMI \< 19 kg/m2 or \> 40 kg/m2 * Currently pregnant, \< 2 years postpartum, lactating * Currently taking any herbal, fiber, or prebiotic supplement * Current or 1-month before the study, taking oral or vaginal antibiotics * Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.

Conditions

Weight Management Obesity Exercise Women Gut Microbiome Metabolome Health Gut Microbiota

Locations

  • Milken Institute School of Public Health, The George Washington University — Washington D.C., District of Columbia, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record