RECRUITING Not applicable ClinicalTrials.gov

The SEQUENCE Trial

Sponsor: Northwestern University • ClinicalTrials.gov ID: NCT06676956

Registry updated: 2026-08-25

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Description

This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd (EBUS) OR staging linear EBUS first, followed by RaB. The goal of this study is to set the standard for optimizing the sequence of bronchoscopic procedures in patients at risk for early-stage malignancy.

Interventions

Linear EBUS first (Diagnostic test)
Patients randomized to this arm will undergo a mediastinal lymph node evaluation with EBUS first, followed by biopsy followed by robotic-assisted bronchoscopy.
Robotic-assisted bronchoscopy first (Diagnostic test)
Patients randomized to this arm will undergo a robotic-assisted bronchoscopy first, followed by a mediastinal lymph node evaluation with EBUS second

Eligibility criteria

Inclusion Criteria: * Peripheral Pulmonary Nodule undergoing a robotic-assisted bronchoscopy Exclusion Criteria: * lymph nodes that are enlarged or PET avid on CT prior to procedure

Conditions

Pulmonary Nodules

Locations

University of California, Davis — Sacramento, California, United States
Northwestern University — Chicago, Illinois, United States
Johns Hopkins University — Baltimore, Maryland, United States
University of Michigan — Ann Arbor, Michigan, United States
University of North Carolina, Chapel Hill — Chapel Hill, North Carolina, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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