RECRUITING Phase 3 ClinicalTrials.gov

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

Sponsor: Alliance for Clinical Trials in Oncology • ClinicalTrials.gov ID: NCT06661720

Registry updated: 2026-09-02

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Description

This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving pembrolizumab and tivozanib together may work better than pembrolizumab alone in treating patients with RCC.

Interventions

Pembrolizumab (Biological)
Given intravenously
Tivozanib (Drug)
Given orally
Biospecimen Collection (Procedure)
Undergo blood sample collection
MRI (Procedure)
Undergo MRI
Computed Tomography (Procedure)
Undergo CT scan
Biopsy (Procedure)
Undergo biopsy
Questionnaire Administration (Other)
Ancillary studies

Eligibility criteria

Inclusion Criteria: * • Histologically confirmed diagnosis of RCC with clear cell component with or without sarcomatoid features following complete resection of the primary tumor (radical or partial nephrectomy) * Note: Patients with microscopically positive soft tissue or vascular margins without gross residual disease are permitted * Intermediate-high risk RCC: * pT2 grade 4 or sarcomatoid features, N0M0 * pT3 any grade N0, M0 * High-risk RCC * pT4, any grade, N0, M0 * pT, any stage., any grade, N+, M0 * cM1 no evidence of disease (NED) RCC * Participants who have had resection of primary tumor (radical or partial nephrectomy) and resection or definitive radiation or ablation of solid, isolated, soft tissue metastases (excluding brain and bone lesions) at the time of primary tumor removal (synchronous) or ≤1 year from primary tumor removal (metachronous) * Surgery (radical or partial nephrectomy or metastasectomy or ablation) \> 4 weeks but =\< 16 weeks prior to study registration with no ongoing complications from surgery * No evidence of disease at time of randomization as assessed by investigator by either CT or MRI scan of the brain and chest, abdomen and pelvis * No prior systemic treatment for RCC * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 (or Karnofsky \>= 60%) * Absolute neutrophil count (ANC) \>= 1,000/mm\^3 * Platelet count \>= 100,000/mm\^3 * Hemoglobin \>= 8 g/dL * Total bilirubin =\< 3 x upper limit of normal (ULN) * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 3 x upper limit of normal (ULN) * Calculated (calc.) creatinine clearance \>= 30 mL/min (using Cockcroft Gault equation or the estimated glomerular filtration rate from the modification of diet in renal disease trial) * Urine protein =\< 1+ on urine analysis (UA) or urine protein creatinine ration (UPCR) \< 2mg/mg * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test is required =\< 14 days prior to registration * HIV status: HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * Hepatitis * Hepatitis B: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with resolved HBV infection, defined as positive hepatitis B core antibody (anti-HBc) and negative hepatitis B surface antigen (HbsAg), are eligible * Hepatitis C: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Cardiac Disease: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class IIB or better * No history of myocarditis * No history of clinically significant pneumonitis * No uncontrolled hypertension (systolic blood pressure \[BP\] \> 150 mm Hg or diastolic BP \> 90 mm Hg) documented on 2 consecutive measurements taken at least 2 hours apart * No serious non-healing wound, ulcer or bone fracture within 28 days prior to registration * No serious/active infection requiring parenteral antibiotics * No moderate or severe hepatic impairment (child-Pugh B or C) * No significant bleeding disorders within 1 month prior to registration, for example: * Hematemesis, hematochezia or other gastrointestinal bleeding grade 3 or higher * Hemoptysis of pulmonary bleeding grade 3 or higher * Hematuria or other genitourinary bleeding grade 3 or higher * No history of allogeneic organ transplantation * No history of allergy of hypersensitivity to study drugs or components * No condition requiring systemic treatment with either corticosteroid (\> 10 mg daily or prednisone equivalent) within 14 days of treatment initiation or other immunosuppressive medications within 30 days of randomization. Inhaled or topical steroids and adrenal replacement doses ≤10 mg daily prednisone equivalent are permitted in absence of active autoimmune disease * No active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis or other gastrointestinal condition associated with increased risk of perforation; history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 4 weeks prior to registration * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * No patients with a history of autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids \> 10 mg/day, or immunosuppressive drugs) with the following exceptions: * Replacement therapy (e.g., thyroxine, insulin, physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed * Brief (\<7 days) use of systemic corticosteroids is allowed when use is considered standard of care * Patients with vitiligo, psoriasis, type 1 diabetes mellitus, hypothyroidism, or resolved childhood asthma/atopy will not be excluded * Patients requiring intermittent use of bronchodilators, inhaled steroids, or local steroid injections will not be excluded * Patients with hypothyroidism that is stable with hormone replacement or Sjögren's syndrome will not be excluded • Chronic concomitant treatment with strong CYP3A4 inducers is not allowed. Patients must discontinue the drug 14 days prior to the start of study treatment

Conditions

Clear Cell Renal Cell Carcinoma Renal Cell Carcinoma (RCC) Stage II Renal Pelvis Cancer AJCC v8 Stage III Renal Pelvis Cancer AJCC v8

Locations

Cancer Center at Saint Joseph's — Phoenix, Arizona, United States
Banner University Medical Center - Tucson — Tucson, Arizona, United States
University of Arizona Cancer Center-North Campus — Tucson, Arizona, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas, United States
University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Sutter Auburn Faith Hospital — Auburn, California, United States
Tower Cancer Research Foundation — Beverly Hills, California, United States
City of Hope Comprehensive Cancer Center — Duarte, California, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California, United States
City of Hope at Irvine Lennar — Irvine, California, United States
UC San Diego Moores Cancer Center — La Jolla, California, United States
City of Hope Antelope Valley — Lancaster, California, United States
Los Angeles General Medical Center — Los Angeles, California, United States
USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
Cedars-Sinai Medical Center — Los Angeles, California, United States
Memorial Medical Center — Modesto, California, United States
USC Norris Oncology/Hematology-Newport Beach — Newport Beach, California, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California, United States
Palo Alto Medical Foundation Health Care — Palo Alto, California, United States
Sutter Roseville Medical Center — Roseville, California, United States
Sutter Medical Center Sacramento — Sacramento, California, United States
University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
UC San Diego Medical Center - Hillcrest — San Diego, California, United States
California Pacific Medical Center-Pacific Campus — San Francisco, California, United States
Mills Health Center — San Mateo, California, United States
Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California, United States
Palo Alto Medical Foundation-Sunnyvale — Sunnyvale, California, United States
City of Hope South Bay — Torrance, California, United States
Torrance Memorial Physician Network - Cancer Care — Torrance, California, United States
City of Hope Upland — Upland, California, United States
Sutter Solano Medical Center/Cancer Center — Vallejo, California, United States
UCHealth University of Colorado Hospital — Aurora, Colorado, United States
UCHealth Memorial Hospital Central — Colorado Springs, Colorado, United States
Memorial Hospital North — Colorado Springs, Colorado, United States
UCHealth - Cherry Creek — Denver, Colorado, United States
Poudre Valley Hospital — Fort Collins, Colorado, United States
Cancer Care and Hematology-Fort Collins — Fort Collins, Colorado, United States
UCHealth Greeley Hospital — Greeley, Colorado, United States
UCHealth Highlands Ranch Hospital — Highlands Ranch, Colorado, United States
UCHealth Lone Tree Health Center — Lone Tree, Colorado, United States
Medical Center of the Rockies — Loveland, Colorado, United States
Hartford HealthCare - Avon — Avon, Connecticut, United States
Hartford HealthCare - Saint Vincent's Medical Center — Bridgeport, Connecticut, United States
Smilow Cancer Hospital-Derby Care Center — Derby, Connecticut, United States
Hartford Healthcare - Fairfield — Fairfield, Connecticut, United States
Smilow Cancer Hospital Care Center-Fairfield — Fairfield, Connecticut, United States
Smilow Cancer Hospital Care Center at Glastonbury — Glastonbury, Connecticut, United States
Smilow Cancer Hospital Care Center at Greenwich — Greenwich, Connecticut, United States
Smilow Cancer Hospital Care Center - Guilford — Guilford, Connecticut, United States
Hartford Hospital — Hartford, Connecticut, United States
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut, United States
Hartford HealthCare - Manchester — Manchester, Connecticut, United States
Midstate Medical Center — Meriden, Connecticut, United States
The Hospital of Central Connecticut — New Britain, Connecticut, United States
Yale University — New Haven, Connecticut, United States
Yale-New Haven Hospital North Haven Medical Center — North Haven, Connecticut, United States
Smilow Cancer Hospital Care Center at Long Ridge — Stamford, Connecticut, United States
Stamford Hospital/Bennett Cancer Center — Stamford, Connecticut, United States
Smilow Cancer Hospital-Torrington Care Center — Torrington, Connecticut, United States
Smilow Cancer Hospital Care Center-Trumbull — Trumbull, Connecticut, United States
Smilow Cancer Hospital-Waterbury Care Center — Waterbury, Connecticut, United States
Smilow Cancer Hospital Care Center - Waterford — Waterford, Connecticut, United States
Beebe South Coastal Health Campus — Millville, Delaware, United States
Helen F Graham Cancer Center — Newark, Delaware, United States
Medical Oncology Hematology Consultants PA — Newark, Delaware, United States
Beebe Health Campus — Rehoboth Beach, Delaware, United States
MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
George Washington University Medical Center — Washington D.C., District of Columbia, United States
UF Health Cancer Institute - Gainesville — Gainesville, Florida, United States
Miami Cancer Institute — Miami, Florida, United States
Grady Health System — Atlanta, Georgia, United States
Emory University Hospital Midtown — Atlanta, Georgia, United States
Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
Emory Johns Creek Hospital — Johns Creek, Georgia, United States
Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
Kootenai Clinic Cancer Services - Sandpoint — Sandpoint, Idaho, United States
Rush-Copley Medical Center — Aurora, Illinois, United States
Advocate Outpatient Center - Aurora — Aurora, Illinois, United States
Advocate Good Shepherd Hospital — Barrington, Illinois, United States
Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
Illinois CancerCare-Canton — Canton, Illinois, United States
SIH Cancer Institute — Carterville, Illinois, United States
Illinois CancerCare-Carthage — Carthage, Illinois, United States
Northwestern University — Chicago, Illinois, United States
Rush MD Anderson Cancer Center — Chicago, Illinois, United States
University of Illinois — Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center — Chicago, Illinois, United States
AMG Crystal Lake - Oncology — Crystal Lake, Illinois, United States
Carle at The Riverfront — Danville, Illinois, United States
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
Decatur Memorial Hospital — Decatur, Illinois, United States
Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
Illinois CancerCare-Dixon — Dixon, Illinois, United States
Advocate Good Samaritan Hospital — Downers Grove, Illinois, United States
Carle Physician Group-Effingham — Effingham, Illinois, United States
Crossroads Cancer Center — Effingham, Illinois, United States
Advocate Sherman Hospital — Elgin, Illinois, United States
Elmhurst Memorial Hospital — Elmhurst, Illinois, United States
Illinois CancerCare-Eureka — Eureka, Illinois, United States
Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
Northwestern Medicine Glenview Outpatient Center — Glenview, Illinois, United States
Northwestern Medicine Grayslake Outpatient Center — Grayslake, Illinois, United States
Advocate South Suburban Hospital — Hazel Crest, Illinois, United States
Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
Northwestern Medicine Lake Forest Hospital — Lake Forest, Illinois, United States
AMG Libertyville - Oncology — Libertyville, Illinois, United States
Condell Memorial Hospital — Libertyville, Illinois, United States
Illinois CancerCare-Macomb — Macomb, Illinois, United States
Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
Trinity Medical Center — Moline, Illinois, United States
Edward Hospital/Cancer Center — Naperville, Illinois, United States
Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
Northwestern Medicine Oak Brook — Oak Brook, Illinois, United States
Advocate Christ Medical Center — Oak Lawn, Illinois, United States
Advocate Outpatient Center - Oak Lawn — Oak Lawn, Illinois, United States
Northwestern Medicine Orland Park — Orland Park, Illinois, United States
Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
Advocate High Tech Medical Park — Palos Heights, Illinois, United States
Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
Illinois CancerCare-Pekin — Pekin, Illinois, United States
Illinois CancerCare-Peoria — Peoria, Illinois, United States
Illinois CancerCare-Peru — Peru, Illinois, United States
Edward Hospital/Cancer Center?Plainfield — Plainfield, Illinois, United States
Illinois CancerCare-Princeton — Princeton, Illinois, United States
UW Health Carbone Cancer Center Rockford — Rockford, Illinois, United States
Memorial Hospital East — Shiloh, Illinois, United States
Southern Illinois University School of Medicine — Springfield, Illinois, United States
Springfield Clinic — Springfield, Illinois, United States
Springfield Memorial Hospital — Springfield, Illinois, United States
Carle Cancer Center — Urbana, Illinois, United States
Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
Illinois CancerCare - Washington — Washington, Illinois, United States
Rush-Copley Healthcare Center — Yorkville, Illinois, United States
IU Health West Hospital — Avon, Indiana, United States
IU Health North Hospital — Carmel, Indiana, United States
Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
Sidney and Lois Eskenazi Hospital — Indianapolis, Indiana, United States
Mary Greeley Medical Center — Ames, Iowa, United States
McFarland Clinic - Ames — Ames, Iowa, United States
University of Iowa Healthcare Cancer Services Quad Cities — Bettendorf, Iowa, United States
McFarland Clinic - Boone — Boone, Iowa, United States
Mercy Hospital — Cedar Rapids, Iowa, United States
Oncology Associates at Mercy Medical Center — Cedar Rapids, Iowa, United States
McFarland Clinic - Trinity Cancer Center — Fort Dodge, Iowa, United States
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
McFarland Clinic - Jefferson — Jefferson, Iowa, United States
McFarland Clinic - Marshalltown — Marshalltown, Iowa, United States
University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
The James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky, United States
Baptist Health Louisville — Louisville, Kentucky, United States
UofL Health Medical Center Northeast — Louisville, Kentucky, United States
Ochsner Medical Center Jefferson — New Orleans, Louisiana, United States
Lafayette Family Cancer Center-EMMC — Brewer, Maine, United States
University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland, United States
UPMC Western Maryland — Cumberland, Maryland, United States
UM Baltimore Washington Medical Center/Tate Cancer Center — Glen Burnie, Maryland, United States
Beverly Hospital — Beverly, Massachusetts, United States
Tufts Medical Center — Boston, Massachusetts, United States
Dana-Farber Cancer Institute — Boston, Massachusetts, United States
Lahey Clinic — Burlington, Massachusetts, United States
Dana-Farber Cancer Institute at Foxborough — Foxborough, Massachusetts, United States
Addison Gilbert Hospital — Gloucester, Massachusetts, United States
Dana Farber-Merrimack Valley — Methuen, Massachusetts, United States
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional — Milford, Massachusetts, United States
Lahey Clinic Peabody — Peabody, Massachusetts, United States
Dana-Farber/Brigham and Women's Cancer Center at South Shore — South Weymouth, Massachusetts, United States
Bronson Battle Creek — Battle Creek, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton — Canton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital — Chelsea, Michigan, United States
OSF Saint Francis Hospital and Medical Group — Escanaba, Michigan, United States
Cancer Hematology Centers - Flint — Flint, Michigan, United States
Genesee Hematology Oncology PC — Flint, Michigan, United States
Genesys Hurley Cancer Institute — Flint, Michigan, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital — Grand Rapids, Michigan, United States
Trinity Health Grand Rapids Hospital — Grand Rapids, Michigan, United States
Bronson Methodist Hospital — Kalamazoo, Michigan, United States
West Michigan Cancer Center — Kalamazoo, Michigan, United States
University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
Trinity Health Muskegon Hospital — Muskegon, Michigan, United States
Corewell Health Lakeland Hospitals - Niles Hospital — Niles, Michigan, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores — Norton Shores, Michigan, United States
Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
Corewell Health Reed City Hospital — Reed City, Michigan, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center — Saint Joseph, Michigan, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital — Saint Joseph, Michigan, United States
Munson Medical Center — Traverse City, Michigan, United States
University of Michigan Health - West — Wyoming, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan, United States
Sanford Joe Lueken Cancer Center — Bemidji, Minnesota, United States
Essentia Health Saint Joseph's Medical Center — Brainerd, Minnesota, United States
Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
Mercy Hospital — Coon Rapids, Minnesota, United States
Essentia Health - Deer River Clinic — Deer River, Minnesota, United States
Essentia Health Cancer Center — Duluth, Minnesota, United States
Fairview Southdale Hospital — Edina, Minnesota, United States
Essentia Health Hibbing Clinic — Hibbing, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood — Maplewood, Minnesota, United States
Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
Hennepin County Medical Center — Minneapolis, Minnesota, United States
Minneapolis VA Medical Center — Minneapolis, Minnesota, United States
North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
Coborn Cancer Center at Saint Cloud Hospital — Saint Cloud, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
Regions Hospital — Saint Paul, Minnesota, United States
United Hospital — Saint Paul, Minnesota, United States
Essentia Health Sandstone — Sandstone, Minnesota, United States
Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
Essentia Health Virginia Clinic — Virginia, Minnesota, United States
Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle — Columbus, Mississippi, United States
Baptist Cancer Center-Grenada — Grenada, Mississippi, United States
University of Mississippi Medical Center — Jackson, Mississippi, United States
Baptist Memorial Hospital and Cancer Center-Union County — New Albany, Mississippi, United States
Baptist Memorial Hospital and Cancer Center-Oxford — Oxford, Mississippi, United States
Baptist Memorial Hospital and Cancer Center-Desoto — Southhaven, Mississippi, United States
Mercy Oncology and Hematology - Clayton-Clarkson — Ballwin, Missouri, United States
Saint Francis Medical Center — Cape Girardeau, Missouri, United States
Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
Parkland Health Center - Farmington — Farmington, Missouri, United States
Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
Washington University School of Medicine — St Louis, Missouri, United States
Mercy Hospital South — St Louis, Missouri, United States
Siteman Cancer Center-South County — St Louis, Missouri, United States
Missouri Baptist Medical Center — St Louis, Missouri, United States
Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
Mercy Hospital Saint Louis — St Louis, Missouri, United States
Missouri Baptist Sullivan Hospital — Sullivan, Missouri, United States
Community Hospital of Anaconda — Anaconda, Montana, United States
Billings Clinic Cancer Center — Billings, Montana, United States
Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
Benefis Sletten Cancer Institute — Great Falls, Montana, United States
Logan Health Medical Center — Kalispell, Montana, United States
Community Medical Center — Missoula, Montana, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center — Lebanon, New Hampshire, United States
Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
Jefferson Cherry Hill Hospital — Cherry Hill, New Jersey, United States
Hackensack University Medical Center — Hackensack, New Jersey, United States
The Cancer Institute of New Jersey Hamilton — Hamilton, New Jersey, United States
Monmouth Medical Center — Long Branch, New Jersey, United States
Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
Morristown Medical Center — Morristown, New Jersey, United States
Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
Rutgers New Jersey Medical School — Newark, New Jersey, United States
Sidney Kimmel Cancer Center Washington Township — Sewell, New Jersey, United States
Robert Wood Johnson University Hospital Somerset — Somerville, New Jersey, United States
Overlook Hospital — Summit, New Jersey, United States
University of New Mexico Cancer Center — Albuquerque, New Mexico, United States
Roswell Park Cancer Institute — Buffalo, New York, United States
Hematology Oncology Associates of CNY at Camillus — Camillus, New York, United States
Memorial Sloan Kettering Commack — Commack, New York, United States
Hematology Oncology Associates of Central New York-East Syracuse — East Syracuse, New York, United States
Glens Falls Hospital — Glens Falls, New York, United States
Memorial Sloan Kettering Westchester — Harrison, New York, United States
Northwell Health/Center for Advanced Medicine — Lake Success, New York, United States
Northern Westchester Hospital — Mount Kisco, New York, United States
Mount Sinai Chelsea — New York, New York, United States
Mount Sinai Hospital — New York, New York, United States
Manhattan Eye Ear and Throat Hospital — New York, New York, United States
Memorial Sloan Kettering Cancer Center — New York, New York, United States
Lenox Hill Hospital — New York, New York, United States
Phelps Memorial Hospital Center — Sleepy Hollow, New York, United States
Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
Memorial Sloan Kettering Nassau — Uniondale, New York, United States
AdventHealth Infusion Center Asheville — Asheville, North Carolina, United States
Duke Cancer Center Cary — Cary, North Carolina, United States
Waverly Hematology Oncology — Cary, North Carolina, United States
UNC Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina, United States
AdventHealth Infusion Center Haywood — Clyde, North Carolina, United States
Duke University Medical Center — Durham, North Carolina, United States
Duke Cancer Center Southpoint — Durham, North Carolina, United States
AdventHealth Hendersonville — Hendersonville, North Carolina, United States
FirstHealth of the Carolinas-Moore Regional Hospital — Pinehurst, North Carolina, United States
Duke Cancer Center Raleigh — Raleigh, North Carolina, United States
AdventHealth Infusion Center Weaverville — Weaverville, North Carolina, United States
Sanford Bismarck Medical Center — Bismarck, North Dakota, United States
Essentia Health Cancer Center-South University Clinic — Fargo, North Dakota, United States
Sanford Broadway Medical Center — Fargo, North Dakota, United States
Sanford Roger Maris Cancer Center — Fargo, North Dakota, United States
UH Seidman Cancer Center at UH Avon Health Center — Avon, Ohio, United States
UHHS-Chagrin Highlands Medical Center — Beachwood, Ohio, United States
Indu and Raj Soin Medical Center — Beavercreek, Ohio, United States
Aultman Health Foundation — Canton, Ohio, United States
Miami Valley Hospital South — Centerville, Ohio, United States
Case Western Reserve University — Cleveland, Ohio, United States
Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
Miami Valley Hospital — Dayton, Ohio, United States
Miami Valley Hospital North — Dayton, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
Miami Valley Cancer Care and Infusion — Greenville, Ohio, United States
Kettering Medical Center — Kettering, Ohio, United States
UH Seidman Cancer Center at Lake Health Mentor Campus — Mentor, Ohio, United States
Upper Valley Medical Center — Troy, Ohio, United States
Cancer Centers of Southwest Oklahoma Research — Lawton, Oklahoma, United States
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
Providence Newberg Medical Center — Newberg, Oregon, United States
Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
Providence Portland Medical Center — Portland, Oregon, United States
Providence Saint Vincent Medical Center — Portland, Oregon, United States
Oregon Health and Science University — Portland, Oregon, United States
Lehigh Valley Hospital-Cedar Crest — Allentown, Pennsylvania, United States
UPMC-Heritage Valley Health System Beaver — Beaver, Pennsylvania, United States
Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania, United States
UPMC Hillman Cancer Center at Butler Health System — Butler, Pennsylvania, United States
Geisinger Medical Center — Danville, Pennsylvania, United States
Geisinger Cancer Center Dickson City — Dickson City, Pennsylvania, United States
Pocono Medical Center — East Stroudsburg, Pennsylvania, United States
UPMC Hillman Cancer Center Erie — Erie, Pennsylvania, United States
UPMC Cancer Centers - Arnold Palmer Pavilion — Greensburg, Pennsylvania, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus — Harrisburg, Pennsylvania, United States
Geisinger Medical Center-Cancer Center Hazleton — Hazleton, Pennsylvania, United States
Lehigh Valley Hospital-Hazleton — Hazleton, Pennsylvania, United States
IRMC Cancer Center — Indiana, Pennsylvania, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center — Johnstown, Pennsylvania, United States
Geisinger Medical Oncology-Lewisburg — Lewisburg, Pennsylvania, United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion — Mechanicsburg, Pennsylvania, United States
UPMC Hillman Cancer Center - Monroeville — Monroeville, Pennsylvania, United States
Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
Jefferson Torresdale Hospital — Philadelphia, Pennsylvania, United States
UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
UPMC-Passavant Hospital — Pittsburgh, Pennsylvania, United States
UPMC-Saint Clair Hospital Cancer Center — Pittsburgh, Pennsylvania, United States
Community Medical Center — Scranton, Pennsylvania, United States
UPMC Cancer Center-Uniontown — Uniontown, Pennsylvania, United States
Geisinger Wyoming Valley/Henry Cancer Center — Wilkes-Barre, Pennsylvania, United States
Divine Providence Hospital — Williamsport, Pennsylvania, United States
Smilow Cancer Hospital Care Center - Westerly — Westerly, Rhode Island, United States
Prisma Health Cancer Institute - Spartanburg — Boiling Springs, South Carolina, United States
Medical University of South Carolina — Charleston, South Carolina, United States
Prisma Health Cancer Institute - Easley — Easley, South Carolina, United States
Gibbs Cancer Center-Gaffney — Gaffney, South Carolina, United States
Tidelands Georgetown Memorial Hospital — Georgetown, South Carolina, United States
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina, United States
Prisma Health Cancer Institute - Faris — Greenville, South Carolina, United States
Prisma Health Cancer Institute - Eastside — Greenville, South Carolina, United States
Prisma Health Cancer Institute - Greer — Greer, South Carolina, United States
Gibbs Cancer Center-Pelham — Greer, South Carolina, United States
Prisma Health Cancer Institute - Seneca — Seneca, South Carolina, United States
Spartanburg Medical Center — Spartanburg, South Carolina, United States
SMC Center for Hematology Oncology Union — Union, South Carolina, United States
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota, United States
Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota, United States
Baptist Memorial Hospital and Cancer Center-Collierville — Collierville, Tennessee, United States
Baptist Memorial Hospital and Cancer Center-Memphis — Memphis, Tennessee, United States
Vanderbilt University/Ingram Cancer Center — Nashville, Tennessee, United States
The Don and Sybil Harrington Cancer Center — Amarillo, Texas, United States
Houston Methodist San Jacinto Hospital — Baytown, Texas, United States
Houston Methodist Cypress Hospital — Cypress, Texas, United States
Parkland Memorial Hospital — Dallas, Texas, United States
UT Southwestern Simmons Cancer Center - RedBird — Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center — Houston, Texas, United States
Houston Methodist Hospital — Houston, Texas, United States
Methodist Willowbrook Hospital — Houston, Texas, United States
Houston Methodist West Hospital — Houston, Texas, United States
Houston Methodist Saint John Hospital — Nassau Bay, Texas, United States
UT Southwestern Clinical Center at Richardson/Plano — Richardson, Texas, United States
Houston Methodist Sugar Land Hospital — Sugar Land, Texas, United States
Scott and White Memorial Hospital — Temple, Texas, United States
Houston Methodist The Woodlands Hospital — The Woodlands, Texas, United States
Central Vermont Medical Center/National Life Cancer Treatment — Berlin Corners, Vermont, United States
University of Vermont Medical Center — Burlington, Vermont, United States
University of Vermont and State Agricultural College — Burlington, Vermont, United States
Dartmouth Cancer Center - North — Saint Johnsbury, Vermont, United States
Bon Secours Memorial Regional Medical Center — Mechanicsville, Virginia, United States
Bon Secours Saint Francis Medical Center — Midlothian, Virginia, United States
Bon Secours Richmond Community Hospital — Richmond, Virginia, United States
Bon Secours Saint Mary's Hospital — Richmond, Virginia, United States
Virginia Cancer Institute — Richmond, Virginia, United States
VCU Massey Cancer Center at Stony Point — Richmond, Virginia, United States
VCU Massey Comprehensive Cancer Center — Richmond, Virginia, United States
VCU Community Memorial Health Center — South Hill, Virginia, United States
United Hospital Center — Bridgeport, West Virginia, United States
West Virginia University Charleston Division — Charleston, West Virginia, United States
WVUH-Berkely Medical Center — Martinsburg, West Virginia, United States
West Virginia University Healthcare — Morgantown, West Virginia, United States
Camden Clark Medical Center — Parkersburg, West Virginia, United States
ThedaCare Regional Cancer Center — Appleton, Wisconsin, United States
Duluth Clinic Ashland — Ashland, Wisconsin, United States
Aurora Cancer Care-Southern Lakes VLCC — Burlington, Wisconsin, United States
Aurora Saint Luke's South Shore — Cudahy, Wisconsin, United States
Aurora Health Care Germantown Health Center — Germantown, Wisconsin, United States
Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Saint Mary's — Green Bay, Wisconsin, United States
Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
Aurora Cancer Care-Kenosha South — Kenosha, Wisconsin, United States
Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center — Madison, Wisconsin, United States
University of Wisconsin Carbone Cancer Center - University Hospital — Madison, Wisconsin, United States
Aurora Bay Area Medical Group-Marinette — Marinette, Wisconsin, United States
Froedtert Menomonee Falls Hospital — Menomonee Falls, Wisconsin, United States
Aurora Cancer Care-Milwaukee — Milwaukee, Wisconsin, United States
Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States
Medical College of Wisconsin — Milwaukee, Wisconsin, United States
Aurora Sinai Medical Center — Milwaukee, Wisconsin, United States
ProHealth D N Greenwald Center — Mukwonago, Wisconsin, United States
Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
Drexel Town Square Health Center — Oak Creek, Wisconsin, United States
ProHealth Oconomowoc Memorial Hospital — Oconomowoc, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Oconto Falls — Oconto Falls, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin, United States
Aurora Cancer Care-Racine — Racine, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sheboygan — Sheboygan, Wisconsin, United States
Sheboygan Physicians Group — Sheboygan, Wisconsin, United States
Vince Lombardi Cancer Clinic-Sheboygan — Sheboygan, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay — Sturgeon Bay, Wisconsin, United States
Aurora Medical Center in Summit — Summit, Wisconsin, United States
Vince Lombardi Cancer Clinic-Two Rivers — Two Rivers, Wisconsin, United States
ProHealth Waukesha Memorial Hospital — Waukesha, Wisconsin, United States
UW Cancer Center at ProHealth Care — Waukesha, Wisconsin, United States
Aurora Cancer Care-Milwaukee West — Wauwatosa, Wisconsin, United States
Aurora West Allis Medical Center — West Allis, Wisconsin, United States
Froedtert West Bend Hospital/Kraemer Cancer Center — West Bend, Wisconsin, United States

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