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RECRUITING Phase 3 ClinicalTrials.gov

A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

Sponsor: Bristol-Myers Squibb • ClinicalTrials.gov ID: NCT06646276

Registry updated: 2026-10-13
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Description

The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.

Interventions

  • BMS-986489 (Atigotatug+Nivolumab) (Biological)
    Specified dose on specified days
  • Atezolizumab (Biological)
    Specified dose on specified days
  • Carboplatin (Drug)
    Specified dose on specified days
  • Etoposide (Drug)
    Specified dose on specified days

Eligibility criteria

Inclusion Criteria * Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-SCLC). * Participants must be Healthy enough to do their normal activities with little or no help based on the ECOG performance scale. * Participants must have at least one tumor that can be measured using special imaging techniques like a CT scan or MRI at a site other than the brain and nervous system Exclusion Criteria * Participants have already received certain types of treatment for extensive stage small cell lung cancer * Participants have certain health conditions, like spread of small cell lung cancer to the brain that are causing symptoms, certain lung diseases, heart diseases, infections, autoimmune diseases, other cancers, or a type of nerve damage called peripheral sensory neuropathy * Other protocol-defined Inclusion/Exclusion criteria apply.

Conditions

Extensive-Stage Small Cell Lung Cancer

Locations

  • Southern Cancer Center, PC — Daphne, Alabama, United States
  • Local Institution - 0283 — Hot Springs, Arkansas, United States
  • Florida Cancer Specialists - South — Fort Myers, Florida, United States
  • Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
  • Florida Cancer Specialists - North — St. Petersburg, Florida, United States
  • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital — Marietta, Georgia, United States
  • Illinois Cancer Care — Peoria, Illinois, United States
  • Local Institution - 0037 — Minneapolis, Minnesota, United States
  • University of New Mexico Comprehensive Cancer Center — Albuquerque, New Mexico, United States
  • Duke Cancer Institute — Durham, North Carolina, United States
  • Sanford Medical Center — Bismarck, North Dakota, United States
  • Sanford Fargo Medical Center — Fargo, North Dakota, United States
  • Oncology Hematology Care — Cincinnati, Ohio, United States
  • Sanford Cancer Center — Sioux Falls, South Dakota, United States
  • SCRI Oncology Partners — Nashville, Tennessee, United States
  • Texas Oncology - Central/South Texas — Austin, Texas, United States
  • Texas Oncology - Northeast Texas — Tyler, Texas, United States
  • Oncology & Hematology Associates of Southwest Virginia, Inc. — Roanoke, Virginia, United States
  • Swedish Cancer Institute - Edmonds — Edmonds, Washington, United States
  • Swedish Medical Center — Seattle, Washington, United States
  • Local Institution - 0079 — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
  • Local Institution - 0077 — ABB, Buenos Aires F.D., Argentina
  • Local Institution - 0100 — Buenos Aires, Buenos Aires F.D., Argentina
  • Local Institution - 0080 — CABA, Buenos Aires F.D., Argentina
  • Local Institution - 0094 — Río Cuarto, Córdoba Province, Argentina
  • Local Institution - 0202 — Campbelltown, New South Wales, Australia
  • Local Institution - 0106 — Penrith, New South Wales, Australia
  • Local Institution - 0105 — Brisbane, Queensland, Australia
  • Local Institution - 0190 — Ballarat Central, Victoria, Australia
  • Local Institution - 0175 — Murdoch, Western Australia, Australia
  • Local Institution - 0253 — Graz, Styria, Austria
  • Local Institution - 0251 — Wels, Upper Austria, Austria
  • Local Institution - 0252 — Linz, Austria
  • Local Institution - 0255 — Rankweil, Austria
  • Local Institution - 0198 — Brussels, Bruxelles-Capitale, Région de, Belgium
  • Local Institution - 0091 — Ghent, Oost-Vlaanderen, Belgium
  • Local Institution - 0187 — Sint-Niklaas, Oost-Vlaanderen, Belgium
  • Local Institution - 0092 — Liège, Belgium
  • Local Institution - 0166 — Fortaleza, Ceará, Brazil
  • Local Institution - 0165 — Porto Alegre, Rio Grande do Sul, Brazil
  • Local Institution - 0169 — Porto Alegre, Rio Grande do Sul, Brazil
  • Local Institution - 0170 — Santa Cruz do Sul, Rio Grande do Sul, Brazil
  • Local Institution - 0163 — Itajaí, Santa Catarina, Brazil
  • Local Institution - 0178 — Barretos, São Paulo, Brazil
  • Local Institution - 0111 — São Paulo, São Paulo, Brazil
  • Local Institution - 0289 — Edmonton, Alberta, Canada
  • Local Institution - 0290 — Chicoutimi, Quebec, Canada
  • Local Institution - 0288 — Québec, Quebec, Canada
  • Local Institution - 0287 — Rimouski, Quebec, Canada
  • Local Institution - 0086 — Santiago, Santiago Metropolitan, Chile
  • Local Institution - 0085 — Santiago, Santiago Metropolitan, Chile
  • Local Institution - 0083 — Santiago, Santiago Metropolitan, Chile
  • Local Institution - 0084 — Santiago, Santiago Metropolitan, Chile
  • Local Institution - 0082 — Viña del Mar, Valparaiso, Chile
  • Local Institution - 0204 — Beijing, Beijing Municipality, China
  • Local Institution - 0336 — Beijing, Beijing Municipality, China
  • Local Institution - 0203 — Chongqing, Chongqing Municipality, China
  • Local Institution - 0308 — Fuzhou, Fujian, China
  • Local Institution - 0212 — Xiamen, Fujian, China
  • Local Institution - 0234 — Shantou, Guangdong, China
  • Local Institution - 0227 — Harbin, Heilongjiang, China
  • Local Institution - 0209 — Wuhan, Hubei, China
  • Local Institution - 0208 — Wuhan, Hubei, China
  • Local Institution - 0216 — Changsha, Hunan, China
  • Local Institution - 0233 — Nanchang, Jiangxi, China
  • Local Institution - 0244 — Changchun, Jilin, China
  • Local Institution - 0235 — Shenyang, Liaoning, China
  • Local Institution - 0335 — Xi'an, Shaanxi, China
  • Local Institution - 0200 — Jinan, Shandong, China
  • Local Institution - 0206 — Shanghai, Shanghai Municipality, China
  • Local Institution - 0210 — Shanghai, Shanghai Municipality, China
  • Local Institution - 0186 — Shanghai, Shanghai Municipality, China
  • Local Institution - 0330 — Chengdu, Sichuan, China
  • Local Institution - 0213 — Tianjin, Tianjin Municipality, China
  • Local Institution - 0236 — Hangzhou, Zhejiang, China
  • Local Institution - 0237 — Hangzhou, Zhejiang, China
  • Local Institution - 0229 — Linhai, Zhejiang, China
  • Local Institution - 0114 — Brno, Brno-město, Czechia
  • Local Institution - 0117 — Ostrava, Ostrava Město, Czechia
  • Local Institution - 0113 — Prague, Praha 4, Czechia
  • Local Institution - 0116 — Olomouc, Czechia
  • Local Institution - 0048 — Montpellier, Hérault, France
  • Local Institution - 0040 — La Tronche, Isère, France
  • Local Institution - 0052 — Lille, Nord, France
  • Local Institution - 0044 — Gleizé, Rhône, France
  • Local Institution - 0051 — Pierre-Bénite, Rhône, France
  • Local Institution - 0047 — Créteil, Val-de-Marne, France
  • Local Institution - 0038 — Villejuif, Val-de-Marne, France
  • Local Institution - 0043 — Marseille, France
  • Local Institution - 0050 — Paris, France
  • Local Institution - 0215 — Quimper, France
  • Local Institution - 0256 — Frankfurt am Main, Hesse, Germany
  • Local Institution - 0262 — Oldenburg, Lower Saxony, Germany
  • Local Institution - 0261 — Cologne, North Rhine-Westphalia, Germany
  • Local Institution - 0265 — Halle, Saxony-Anhalt, Germany
  • Local Institution - 0257 — Bad Berka, Thuringia, Germany
  • Local Institution - 0258 — Gauting, Germany
  • Local Institution - 0259 — Großhansdorf, Germany
  • Local Institution - 0260 — Heidelberg, Germany
  • Local Institution - 0264 — Stuttgart, Germany
  • Local Institution - 0063 — Athens, Attikí, Greece
  • Local Institution - 0064 — Athens, Attikí, Greece
  • Local Institution - 0062 — Thessaloniki, Kentrikí Makedonía, Greece
  • Local Institution - 0058 — Thessaloniki, Thessaloníki, Greece
  • Local Institution - 0059 — Larissa, Thessalía, Greece
  • Local Institution - 0274 — Bengaluru, Karnataka, India
  • Local Institution - 0278 — New Delhi, National Capital Territory of Delhi, India
  • Local Institution - 0271 — Madurai, Tamil Nadu, India
  • Local Institution - 0277 — Varanasi, Uttar Pradesh, India
  • Local Institution - 0273 — Kolkata, West Bengal, India
  • Local Institution - 0072 — Naples, Campania, Italy
  • Local Institution - 0068 — Milan, Lombardy, Italy
  • Local Institution - 0069 — Rome, Roma, Italy
  • Local Institution - 0110 — Perugia, Umbria, Italy
  • Local Institution - 0070 — Peschiera del Garda, Verona, Italy
  • Local Institution - 0074 — Bologna, Italy
  • Local Institution - 0067 — Milan, Italy
  • Local Institution - 0319 — Matsuyama, Ehime, Japan
  • Local Institution - 0292 — Kurume, Fukuoka, Japan
  • Local Institution - 0313 — Sapporo, Hokkaido, Japan
  • Local Institution - 0323 — Kobe, Hyōgo, Japan
  • Local Institution - 0321 — Kanazawa, Ishikawa-ken, Japan
  • Local Institution - 0316 — Yokohama, Kanagawa, Japan
  • Local Institution - 0291 — Sendai, Miyagi, Japan
  • Local Institution - 0324 — Kashihara, Nara, Japan
  • Local Institution - 0328 — Kurashiki, Okayama-ken, Japan
  • Local Institution - 0317 — Hirakata, Osaka, Japan
  • Local Institution - 0314 — Ōsaka-sayama, Osaka, Japan
  • Local Institution - 0325 — Takatsuki, Osaka, Japan
  • Local Institution - 0320 — Hidaka, Saitama, Japan
  • Local Institution - 0318 — Ina-machi, Saitama, Japan
  • Local Institution - 0322 — Hamamatsu, Shizuoka, Japan
  • Local Institution - 0326 — Bunkyo-ku, Tokyo, Japan
  • Local Institution - 0315 — Koto, Tokyo, Japan
  • Local Institution - 0327 — Fukushima, Japan
  • Local Institution - 0310 — Kuala Lumpur, Kuala Lumpur, Malaysia
  • Local Institution - 0312 — Kuala Lumpur, Kuala Lumpur, Malaysia
  • Local Institution - 0311 — Kuching, Sarawak, Malaysia
  • Local Institution - 0146 — Guadalajara, Jalisco, Mexico
  • Local Institution - 0145 — Puebla City, Mexico
  • Local Institution - 0097 — Amsterdam, North Holland, Netherlands
  • Local Institution - 0099 — Arnhem, Netherlands
  • Local Institution - 0098 — Groningen, Netherlands
  • Local Institution - 0193 — Konin, Greater Poland Voivodeship, Poland
  • Local Institution - 0241 — Poznan, Greater Poland Voivodeship, Poland
  • Local Institution - 0192 — Prabuty, Pomeranian Voivodeship, Poland
  • Local Institution - 0195 — Bydgoszcz, Poland
  • Local Institution - 0189 — Lodz, Łódź Voivodeship, Poland
  • Local Institution - 0133 — Bucharest, Bucharest, Romania
  • Local Institution - 0135 — Bucharest, Bucharest, Romania
  • Local Institution - 0137 — Florești, Cluj, Romania
  • Local Institution - 0140 — Craiova, Dolj, Romania
  • Local Institution - 0141 — Cluj-Napoca, Romania
  • Local Institution - 0139 — Iași, Romania
  • Local Institution - 0132 — Iași, Romania
  • Local Institution - 0305 — Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea
  • Local Institution - 0286 — Seongnam, Kyǒnggi-do, South Korea
  • Local Institution - 0304 — Suwon, Kyǒnggi-do, South Korea
  • Local Institution - 0285 — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
  • Local Institution - 0293 — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
  • Local Institution - 0309 — Daegu, Taegu-Kwangyǒkshi, South Korea
  • Local Institution - 0300 — Santiago de Compostela, A Coruña [La Coruña], Spain
  • Local Institution - 0294 — Barcelona, Catalunya [Cataluña], Spain
  • Local Institution - 0302 — Barcelona, Catalunya [Cataluña], Spain
  • Local Institution - 0301 — Jaén, Jaén, Spain
  • Local Institution - 0298 — Madrid, Madrid, Comunidad de, Spain
  • Local Institution - 0296 — Madrid, Madrid, Comunidad de, Spain
  • Local Institution - 0297 — Majadahonda, Madrid, Comunidad de, Spain
  • Local Institution - 0303 — Valencia, Valenciana, Comunitat, Spain
  • Local Institution - 0299 — Seville, Spain
  • Local Institution - 0295 — Seville, Spain
  • Local Institution - 0248 — Chur, Switzerland
  • Local Institution - 0249 — Winterthur, Switzerland
  • Local Institution - 0247 — Zurich, Switzerland
  • Local Institution - 0158 — Çiğli, İzmir, Turkey (Türkiye)
  • Local Institution - 0154 — Adana, Turkey (Türkiye)
  • Local Institution - 0157 — Ankara, Turkey (Türkiye)
  • Local Institution - 0177 — Ankara, Turkey (Türkiye)
  • Local Institution - 0153 — Istanbul, Turkey (Türkiye)
  • Local Institution - 0183 — Central Middlesbrough, Middlesbrough, United Kingdom
  • Local Institution - 0159 — Aberdeen, United Kingdom
  • Local Institution - 0101 — Manchester, United Kingdom
  • Local Institution - 0226 — Metropolitan Borough of Wirral, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record