Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

Description

This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)

Interventions

• Daptomycin for Injection (Drug)
  Daptomycin given by injection at a dose determined by the treating team but not to be less than 6mg/kg
• Vancomycin (IV) (Drug)
  Vancomycin by injection to be given at a dose selected by the treating team to achieve a desired trough level or AUC-based target, as determined by local standards of care

Eligibility criteria

Conditions

Locations

• Blacktown Hospital — Blacktown, New South Wales, Australia
• Concord Repatriation and General Hospital — Concord, New South Wales, Australia
• John Hunter Hospital — Newcastle, New South Wales, Australia
• Westmead Hospital — Westmead, New South Wales, Australia
• Royal Brisbane and Women's Hospital — Herston, Queensland, Australia
• Flinders Medical Centre — Bedford Park, South Australia, Australia
• Monash Health - Casey Hospital — Berwick, Victoria, Australia
• Box Hill Hospital — Box Hill, Victoria, Australia
• Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital) — Clayton, Victoria, Australia
• Royal Melbourne Hospital — Parkville, Victoria, Australia
• Fiona Stanley Hospital — Murdoch, Western Australia, Australia
• Royal Perth Hospital — Perth, Western Australia, Australia
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Fraser Health Authority (Surrey Memorial Hospital) — Surrey, British Columbia, Canada
• Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital) — St. John's, Newfoundland and Labrador, Canada
• Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital) — Hamilton, Ontario, Canada
• Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada
• Jewish General Hospital — Montreal, Quebec, Canada
• McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital) — Montreal, Quebec, Canada
• Middlemore Hospital — Otahuhu, Auckland, New Zealand