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RECRUITING Phase 1 ClinicalTrials.gov

Inflammatory Challenge and Fear

Sponsor: University of California, San Francisco • ClinicalTrials.gov ID: NCT06630884

Registry updated: 2026-09-21
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Description

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.

Interventions

  • Typhoid VI Polysaccharide Vaccine Injectable Solution (Biological)
    Salmonella typhi capsular polysaccharide vaccine (Typhoid Vi Polysaccharide Vaccine): Each dose of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA) is formulated to contain 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection. It is indicated for use by humans aged 2 years and older for protection against typhoid fever.
  • Saline Placebo (0.5mL injection) (Other)
    The placebo injection will consist of 0.5mL of saline.

Eligibility criteria

Inclusion Criteria: All Subjects: 1. Aged 18-65 years old 2. Trauma Exposed 3. Current PTSD/No history of PTSD Exclusion Criteria: 1. Contraindications to typhoid vaccine 2. Conditions associated with inflammation 3. Pregnancy or plans to become pregnant in next three months

Conditions

Posttraumatic Stress Disorder (PTSD)

Locations

  • San Francisco VA Health Care System — San Francisco, California, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record