RECRUITING Not applicable ClinicalTrials.gov

Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans

Sponsor: VA Office of Research and Development • ClinicalTrials.gov ID: NCT06627569

Registry updated: 2026-10-05

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Description

The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.

Interventions

Exercise (Behavioral)
12 weeks of aerobic exercise, with 4 sessions per week.

Eligibility criteria

Inclusion Criteria: * Veteran * Body mass index (BMI) of 25 or greater * Physically inactive * Able to attend study visits in person in Aurora, CO Exclusion Criteria: * Currently pregnant * History of bariatric surgery * Current eating disorder * Current treatment with appetite-altering medications (e.g., glucagon-like peptide-1 (GLP-1) agonists) * Contraindication to MRI (weight \> 500 pounds (lbs); claustrophobia; metal or electronic devices in the body) * Cardiovascular disease, chronic kidney disease, pulmonary disease, or diabetes * Unable to exercise due to cardiac, pulmonary, neurologic, or orthopedic reasons

Conditions

Overweight/Obesity Stress

Locations

Rocky Mountain Regional VA Medical Center, Aurora, CO — Aurora, Colorado, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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