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RECRUITING Phase 2 ClinicalTrials.gov

Prevent Cardiac Surgery Associated AKI Trial

Sponsor: George Washington University • ClinicalTrials.gov ID: NCT06620523

Registry updated: 2026-10-14
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Description

Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily 1200 mg of Co enzyme Q10 (CoQ10) and 1000 mg of Glutathione (GSH), the first dose will be given the day before surgery and continues while admitted up to 1 week. Blood and urine samples will be collected. Adverse events related to the study drugs will be collected.

Interventions

  • CoQ10 1200 mg orally with Glutathione 1000 mg orally (Drug)
    This is the intervention to assess efficacy of CoQ10 and Glutathione in prevention of cardiac surgery associated acute kidney injury
  • Group B: Placebo CoQ10 orally and Placebo Glutathione orally (Drug)
    A placebo to exactly match the CoQ10 will be made with white gelatin empty capsules containing cellulose AND a placebo to exactly match the L-Glutathione will be made with white gelatin empty capsules containing cellulose.

Eligibility criteria

Inclusion Criteria: * Adult 18-70 years of age * Undergoing elective CPB (Cardiopulmonary Bypass) surgery * Baseline GFR (Glomerular Filtration Rate) ≥45 ml/min Exclusion Criteria: * GFR (Glomerular Filtration Rate) \<45 ml/min * Solitary kidney * Status post-kidney transplant * Pregnant women * Allergy to CoQ10 * Allergy to Glutathione * Allergy to Cellulose

Conditions

Renal Failure Coronary Artery Disease Surgery Surgery-Complications

Locations

  • George Washington University Hospital — Washington D.C., District of Columbia, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record