RECRUITING Phase 2 / Phase 3 ClinicalTrials.gov

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

Sponsor: SWOG Cancer Research Network • ClinicalTrials.gov ID: NCT06616584

Registry updated: 2026-10-09

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Description

This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel and ramucirumab alone in treating patients with non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Cemiplimab is a monoclonal antibody that stimulates the immune system by blocking the PD-1 pathway. Tumors use the PD-1 pathway to escape attacks from the immune system. By blocking the PD-1 pathway, cemiplimab may help the immune system recognize and attack tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Adding cemiplimab to usual treatment, docetaxel and ramucirumab, may kill more tumor cells compared to docetaxel and ramucirumab alone in treating patients with stage IV or recurrent non-small cell lung cancer.

Interventions

Biospecimen Collection (Procedure)
Undergo blood sample collection
Cemiplimab (Biological)
Given IV
Computed Tomography (Procedure)
Undergo CT
Dexamethasone (Drug)
Given PO
Docetaxel (Drug)
Given IV
Magnetic Resonance Imaging (Procedure)
Undergo MRI
Ramucirumab (Biological)
Given IV

Eligibility criteria

Inclusion Criteria: * Participants must have been assigned to S1800E by the Southwest Oncology Group (SWOG) Statistics and Data Management Center (SDMC). Assignment to S1800E is determined by the LUNGMAP protocol * Participants must have measurable or non-measurable disease documented by CT or MRI. The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to randomization. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to randomization. All disease must be assessed and documented on the Baseline Tumor Assessment Form. Participants whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to registration * Participants must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to randomization * Participants must have received exactly one anti-PD-1 or anti-PD-L1 therapy for advanced disease (stage IV or recurrent disease, or stage I-III disease in certain circumstances outlined below). Anti-PD-1 or anti-PD-L1 therapy may have been given alone or in combination with other therapy. For participants who received neoadjuvant, adjuvant, and/or consolidation anti-PD-1 or anti-PD-L1 therapy for stage I-III disease: * If they experienced disease progression within (≤) 365 days from initiation (cycle 1 day 1) or anti-PD-1 or anti-PD-L1 therapy, this counts as the single allowed anti-PD-1 or anti-PD-L1 therapy for advanced disease * If they experienced disease progression more than (\>) 365 days from initiation (cycle 1 day 1) or anti-PD-1 or anti-PD-L1 therapy, this is not considered anti-PD-1 or anti-PD-L1 therapy for advance disease. These participants must have received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease * Participants must have experienced disease progression (in the opinion of the treating investigator) more than (\>) 84 days following initiation (cycle 1 day 1) of their most recent anti-PD-1 or anti-PD-L1 therapy * Participants who received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease must have had a best response of stable disease, partial response or complete response (in the opinion of the treating investigator) on the anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease * Participants must have received platinum-based chemotherapy and experienced disease progression (in the opinion of the treating investigator) during or after this regimen * Participants with a known sensitizing molecular alteration for which a Food and Drug Administration (FDA)-approved targeted therapy for NSCLC exists (e.g., EGFR, ALK, ROS1, BRAF, RET, NTRK, KRAS, HER2, and MET sensitizing mutations), must have previously received at least one of the approved therapy(s). Prior targeted therapy for participants with targetable alterations is allowed if all other eligibility criteria are also met * Participants must have recovered (≤ grade 1) from any side effects from the most recent anti-cancer treatment prior to randomization * Participants must not have received prior therapy with docetaxel for this disease * Participants must not have received any palliative radiation therapy within 14 days (or palliative bone radiation therapy within 7 days) prior to randomization * Participants must not be planning to receive any concurrent chemotherapy, immunotherapy, or biologic therapy for cancer treatment while receiving treatment on this study * Participants must not have undergone major surgery within 28 days prior to randomization, or subcutaneous venous access device placement within 7 days prior to randomization. Participants must not have postoperative bleeding complications or wound complications from a surgical procedure performed within 2 months prior to randomization. The participant must not have elective or planned major surgery to be performed during the course of this study * Absolute neutrophil count ≥ 1.5 x 10\^3/uL (within 28 days prior to randomization) * Hemoglobin ≥ 9.0 g/dL (within 28 days prior to randomization) * Platelets ≥ 100 x 10\^3/uL (within 28 days prior to randomization) * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (within 28 days prior to randomization) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin ≤ 5 x institutional ULN * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN (within 28 days prior to randomization). Participants with history of liver metastasis must have AST and ALT ≤ 5 x ULN * Participants must have a creatinine ≤ the institutional (I)ULN or calculated creatinine clearance ≥ 50 mL/min using the following Cockcroft-Gault formula. This specimen must have been drawn and processed within 28 days prior to randomization * Participants must have a urinary protein test performed within 28 days prior to randomization * Participants' most recent Zubrod/Eastern Cooperative Oncology Group (ECOG) performance status must be 0-1 and be documented within 28 days prior to randomization * Participants must have a completed medical history and physical exam within 28 days prior to randomization * Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load while on suppressive therapy on the most recent test results obtained within 6 months prior to randomization, if indicated by the treating investigator * Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants currently being treated for HCV infection must have undetectable HCV viral load test on the most recent test results obtained within 6 months prior to randomization, if indicated by the treating investigator * Participants with known human immunodeficiency virus (HIV) infection are eligible, provided they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to randomization * Participants must not have a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen * Participants must not have an active autoimmune disease that has required systemic treatment within 730 days prior to randomization (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed * Participants must not have any history of primary immunodeficiency * Participants must be able to safely receive study therapy and must not have experienced the following: * Any grade 3 or worse immune-mediated adverse event. Exception: asymptomatic nonbullous/nonexfoliative rash * Any unresolved grade 2 immune-mediated adverse event * Any toxicity that led to permanent discontinuation of prior anti-PD-1/PD-L1 immunotherapy * Exception to the above: Toxicities of any grade that requires replacement therapy and has stabilized on therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) are allowed * Participants must not have any history of organ transplant that requires use of immunosuppressives * Participants must not have received a live or live attenuated vaccine within 28 days prior to randomization. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever rabies, Bacillus Calmette-Guerin (BCG) and typhoid vaccine. Seasonal influenza vaccines and COVID-19 vaccines are allowed, however, intranasal influenza vaccines (e.g. Flu-Mist) are live attenuated and are not allowed * Participants must not have clinical signs or symptoms of active tuberculosis infection * Participants must not have a history of (non-infectious) pneumonitis that required steroids or current pneumonitis/interstitial lung disease * Participants must not have had a serious or nonhealing wound, ulcer, or bone fracture within 28 days prior to randomization * Participants must not have a history of gastrointestinal perforation or fistula within 6 months prior to randomization * Participants must not have grade 3-4 gastrointestinal bleeding (defined by National Cancer Institute \[NCI\] Common Terminology Criteria for Adverse Events \[CTCAE\] version \[v\]5) within 3 months prior to randomization. No history of gastrointestinal (GI) bleed within 3 months prior to randomization * Participants must not have any grade III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., participants with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months prior to randomization, or serious uncontrolled cardiac arrhythmia * Participants must not have experienced any arterial thromboembolic events, including but not limited to myocardial infarction, transient ischemic attack, cerebrovascular accident, or unstable angina, within 6 months prior to randomization * Participants must not have gross hemoptysis within two months prior to randomization (defined as bright red blood or ≥ 1/2 teaspoon) or with radiographic evidence of intratumor cavitation or has radiologically documented evidence of major blood vessel invasion or encasement by cancer * Participants must not have been diagnosed with venous thrombosis within 3 months prior to randomization. Participants with venous thrombosis diagnosed more than 3 months prior to randomization must be on stable doses of anticoagulants * Participants must not have cirrhosis at a level of Child-Pugh B (or worse) AND a history of hepatic encephalopathy or clinically meaningful ascites resulting from cirrhosis, OR any degree of cirrhosis * Participants must not be pregnant or breastfeeding (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped). Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen * Participants must agree to have blood specimens submitted for circulating tumor DNA (ctDNA) * Participants must be offered participation in specimen banking. With participant consent, specimens must be collected and submitted via the SWOG specimen tracking system * NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. NOTE: Participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations

Conditions

Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8

Locations

Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis — Daphne, Alabama, United States
Thomas Hospital — Fairhope, Alabama, United States
Mobile Infirmary Medical Center — Mobile, Alabama, United States
Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland — Saraland, Alabama, United States
Katmai Oncology Group — Anchorage, Alaska, United States
Banner University Medical Center - Tucson — Tucson, Arizona, United States
University of Arizona Cancer Center-North Campus — Tucson, Arizona, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas, United States
Kaiser Permanente-Anaheim — Anaheim, California, United States
Kaiser Permanente-Baldwin Park — Baldwin Park, California, United States
Kaiser Permanente-Bellflower — Bellflower, California, United States
Tower Cancer Research Foundation — Beverly Hills, California, United States
Marshall Cancer Center — Cameron Park, California, United States
Enloe Medical Center — Chico, California, United States
City of Hope Comprehensive Cancer Center — Duarte, California, United States
Kaiser Permanente-Fontana — Fontana, California, United States
Kaiser Permanente Fresno Orchard Plaza — Fresno, California, United States
Kaiser Permanente-Fresno — Fresno, California, United States
Kaiser Permanente South Bay — Harbor City, California, United States
City of Hope at Irvine Lennar — Irvine, California, United States
Kaiser Permanente-Irvine — Irvine, California, United States
UC San Diego Moores Cancer Center — La Jolla, California, United States
City of Hope Antelope Valley — Lancaster, California, United States
Loma Linda University Medical Center — Loma Linda, California, United States
Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
Kaiser Permanente West Los Angeles — Los Angeles, California, United States
Cedars-Sinai Medical Center — Los Angeles, California, United States
Fremont - Rideout Cancer Center — Marysville, California, United States
Mather Veteran Affairs Medical Center — Mather, California, United States
Kaiser Permanente-Oakland — Oakland, California, United States
Kaiser Permanente-Ontario — Ontario, California, United States
VA Palo Alto Health Care System — Palo Alto, California, United States
Kaiser Permanente - Panorama City — Panorama City, California, United States
Eisenhower Medical Center — Rancho Mirage, California, United States
Kaiser Permanente-Riverside — Riverside, California, United States
Kaiser Permanente-Roseville — Roseville, California, United States
Kaiser Permanente Downtown Commons — Sacramento, California, United States
University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
Kaiser Permanente-San Diego Zion — San Diego, California, United States
Kaiser Permanente-San Francisco — San Francisco, California, United States
Veterans Affairs Medical Center - San Francisco — San Francisco, California, United States
Kaiser Permanente-Santa Teresa-San Jose — San Jose, California, United States
Kaiser Permanente San Leandro — San Leandro, California, United States
Kaiser Permanente-San Marcos — San Marcos, California, United States
Mills Health Center — San Mateo, California, United States
Kaiser San Rafael-Gallinas — San Rafael, California, United States
Ridley-Tree Cancer Center — Santa Barbara, California, United States
Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
Kaiser Permanente-South San Francisco — South San Francisco, California, United States
Cedars-Sinai Cancer - Tarzana — Tarzana, California, United States
City of Hope South Bay — Torrance, California, United States
Torrance Memorial Physician Network - Cancer Care — Torrance, California, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center — Truckee, California, United States
City of Hope Upland — Upland, California, United States
Kaiser Permanente-Vallejo — Vallejo, California, United States
Kaiser Permanente-Walnut Creek — Walnut Creek, California, United States
Presbyterian Intercommunity Hospital — Whittier, California, United States
Kaiser Permanente-Woodland Hills — Woodland Hills, California, United States
Smilow Cancer Hospital-Derby Care Center — Derby, Connecticut, United States
Smilow Cancer Hospital Care Center-Fairfield — Fairfield, Connecticut, United States
Smilow Cancer Hospital Care Center at Glastonbury — Glastonbury, Connecticut, United States
Smilow Cancer Hospital Care Center at Greenwich — Greenwich, Connecticut, United States
Smilow Cancer Hospital Care Center - Guilford — Guilford, Connecticut, United States
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut, United States
Yale University — New Haven, Connecticut, United States
Yale-New Haven Hospital North Haven Medical Center — North Haven, Connecticut, United States
Smilow Cancer Hospital Care Center at Long Ridge — Stamford, Connecticut, United States
Smilow Cancer Hospital-Torrington Care Center — Torrington, Connecticut, United States
Smilow Cancer Hospital Care Center-Trumbull — Trumbull, Connecticut, United States
Smilow Cancer Hospital-Waterbury Care Center — Waterbury, Connecticut, United States
Smilow Cancer Hospital Care Center - Waterford — Waterford, Connecticut, United States
Veterans Affairs Connecticut Healthcare System-West Haven Campus — West Haven, Connecticut, United States
Beebe South Coastal Health Campus — Millville, Delaware, United States
Helen F Graham Cancer Center — Newark, Delaware, United States
Medical Oncology Hematology Consultants PA — Newark, Delaware, United States
Beebe Health Campus — Rehoboth Beach, Delaware, United States
Kaiser Permanente-Capitol Hill Medical Center — Washington D.C., District of Columbia, United States
Malcom Randall Veterans Administration Medical Center — Gainesville, Florida, United States
Moffitt Cancer Center — Tampa, Florida, United States
Grady Health System — Atlanta, Georgia, United States
Emory University Hospital Midtown — Atlanta, Georgia, United States
Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
Northside Hospital — Atlanta, Georgia, United States
Atlanta VA Medical Center — Decatur, Georgia, United States
Emory Decatur Hospital — Decatur, Georgia, United States
Northside Hospital - Duluth — Duluth, Georgia, United States
Northeast Georgia Medical Center-Gainesville — Gainesville, Georgia, United States
Emory Johns Creek Hospital — Johns Creek, Georgia, United States
Northside Hospital - Gwinnett — Lawrenceville, Georgia, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler — Savannah, Georgia, United States
Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
Idaho Urologic Institute-Meridian — Meridian, Idaho, United States
Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
Kootenai Clinic Cancer Services - Sandpoint — Sandpoint, Idaho, United States
Advocate Outpatient Center - Aurora — Aurora, Illinois, United States
Advocate Good Shepherd Hospital — Barrington, Illinois, United States
Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
Illinois CancerCare-Canton — Canton, Illinois, United States
Illinois CancerCare-Carthage — Carthage, Illinois, United States
Northwestern University — Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center — Chicago, Illinois, United States
AMG Crystal Lake - Oncology — Crystal Lake, Illinois, United States
Carle at The Riverfront — Danville, Illinois, United States
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
Decatur Memorial Hospital — Decatur, Illinois, United States
Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
Illinois CancerCare-Dixon — Dixon, Illinois, United States
Advocate Good Samaritan Hospital — Downers Grove, Illinois, United States
Carle Physician Group-Effingham — Effingham, Illinois, United States
Crossroads Cancer Center — Effingham, Illinois, United States
Advocate Sherman Hospital — Elgin, Illinois, United States
Illinois CancerCare-Eureka — Eureka, Illinois, United States
Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
Northwestern Medicine Glenview Outpatient Center — Glenview, Illinois, United States
Northwestern Medicine Grayslake Outpatient Center — Grayslake, Illinois, United States
Advocate South Suburban Hospital — Hazel Crest, Illinois, United States
Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
Northwestern Medicine Lake Forest Hospital — Lake Forest, Illinois, United States
AMG Libertyville - Oncology — Libertyville, Illinois, United States
Condell Memorial Hospital — Libertyville, Illinois, United States
Illinois CancerCare-Macomb — Macomb, Illinois, United States
Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
Loyola University Medical Center — Maywood, Illinois, United States
Carle BroMenn Medical Center — Normal, Illinois, United States
Carle Cancer Institute Normal — Normal, Illinois, United States
Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
HSHS Saint Elizabeth's Hospital — O'Fallon, Illinois, United States
Northwestern Medicine Oak Brook — Oak Brook, Illinois, United States
Advocate Christ Medical Center — Oak Lawn, Illinois, United States
Advocate Outpatient Center - Oak Lawn — Oak Lawn, Illinois, United States
Northwestern Medicine Orland Park — Orland Park, Illinois, United States
Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
Advocate High Tech Medical Park — Palos Heights, Illinois, United States
Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
Illinois CancerCare-Pekin — Pekin, Illinois, United States
Illinois CancerCare-Peoria — Peoria, Illinois, United States
Illinois CancerCare-Peru — Peru, Illinois, United States
Illinois CancerCare-Princeton — Princeton, Illinois, United States
Memorial Hospital East — Shiloh, Illinois, United States
Southern Illinois University School of Medicine — Springfield, Illinois, United States
Springfield Clinic — Springfield, Illinois, United States
Springfield Memorial Hospital — Springfield, Illinois, United States
Carle Cancer Center — Urbana, Illinois, United States
Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
Illinois CancerCare - Washington — Washington, Illinois, United States
Northwest Cancer Center - Crown Point — Crown Point, Indiana, United States
Northwest Oncology LLC — Dyer, Indiana, United States
Saint Mary Medical Center — Hobart, Indiana, United States
Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
Richard L. Roudebush Veterans Affairs Medical Center — Indianapolis, Indiana, United States
Sidney and Lois Eskenazi Hospital — Indianapolis, Indiana, United States
Saint Catherine Hospital — Indianapolis, Indiana, United States
The Community Hospital — Munster, Indiana, United States
Women's Diagnostic Center - Munster — Munster, Indiana, United States
Northwest Cancer Center - Valparaiso — Valparaiso, Indiana, United States
University of Iowa Healthcare Cancer Services Quad Cities — Bettendorf, Iowa, United States
Physicians' Clinic of Iowa PC — Cedar Rapids, Iowa, United States
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
University of Kansas Clinical Research Center — Fairway, Kansas, United States
HaysMed — Hays, Kansas, United States
University of Kansas Cancer Center — Kansas City, Kansas, United States
Lawrence Memorial Hospital — Lawrence, Kansas, United States
Veteran Administration Eastern Kansas Healthcare — Leavenworth, Kansas, United States
The University of Kansas Cancer Center - Olathe — Olathe, Kansas, United States
University of Kansas Cancer Center-Overland Park — Overland Park, Kansas, United States
University of Kansas Hospital-Indian Creek Campus — Overland Park, Kansas, United States
Salina Regional Health Center — Salina, Kansas, United States
University of Kansas Health System Saint Francis Campus — Topeka, Kansas, United States
University of Kansas Hospital-Westwood Cancer Center — Westwood, Kansas, United States
Markey Cancer Center at Lexington Clinic — Lexington, Kentucky, United States
University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
Harold Alfond Center for Cancer Care — Augusta, Maine, United States
MaineHealth Waldo Hospital — Belfast, Maine, United States
Lafayette Family Cancer Center-EMMC — Brewer, Maine, United States
MaineHealth Cancer Care and IV Therapy - Brunswick — Brunswick, Maine, United States
MaineHealth LincolnHealth Hospital — Damariscotta, Maine, United States
Penobscot Bay Medical Center — Rockport, Maine, United States
MaineHealth Cancer Care Center of York County — Sanford, Maine, United States
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine, United States
MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine, United States
UM Upper Chesapeake Hematology and Oncology - Aberdeen — Aberdeen, Maryland, United States
Saint Agnes Hospital — Baltimore, Maryland, United States
Kaiser Permanente-Woodlawn Medical Center — Baltimore, Maryland, United States
UM Upper Chesapeake Medical Center — Bel Air, Maryland, United States
UPMC Western Maryland — Cumberland, Maryland, United States
Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland, United States
Kaiser Permanente - Largo Medical Center — Largo, Maryland, United States
Kaiser Permanente Lutherville - Timonium Medical Center — Lutherville, Maryland, United States
Beverly Hospital — Beverly, Massachusetts, United States
Lahey Clinic — Burlington, Massachusetts, United States
Addison Gilbert Hospital — Gloucester, Massachusetts, United States
Lahey Clinic Peabody — Peabody, Massachusetts, United States
Baystate Medical Center — Springfield, Massachusetts, United States
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton — Canton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital — Chelsea, Michigan, United States
OSF Saint Francis Hospital and Medical Group — Escanaba, Michigan, United States
Cancer Hematology Centers - Flint — Flint, Michigan, United States
Genesee Hematology Oncology PC — Flint, Michigan, United States
Genesys Hurley Cancer Institute — Flint, Michigan, United States
University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan, United States
Sanford Joe Lueken Cancer Center — Bemidji, Minnesota, United States
Essentia Health Saint Joseph's Medical Center — Brainerd, Minnesota, United States
Mercy Hospital — Coon Rapids, Minnesota, United States
Essentia Health - Deer River Clinic — Deer River, Minnesota, United States
Essentia Health Cancer Center — Duluth, Minnesota, United States
Fairview Southdale Hospital — Edina, Minnesota, United States
Essentia Health Hibbing Clinic — Hibbing, Minnesota, United States
Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
Mayo Clinic in Rochester — Rochester, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
Regions Hospital — Saint Paul, Minnesota, United States
United Hospital — Saint Paul, Minnesota, United States
Essentia Health Sandstone — Sandstone, Minnesota, United States
Essentia Health Virginia Clinic — Virginia, Minnesota, United States
Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
Sanford Cancer Center Worthington — Worthington, Minnesota, United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle — Columbus, Mississippi, United States
Baptist Cancer Center-Grenada — Grenada, Mississippi, United States
Gulfport Memorial Hospital — Gulfport, Mississippi, United States
Baptist Memorial Hospital and Cancer Center-Union County — New Albany, Mississippi, United States
Baptist Memorial Hospital and Cancer Center-Oxford — Oxford, Mississippi, United States
Baptist Memorial Hospital and Cancer Center-Desoto — Southhaven, Mississippi, United States
Saint Francis Medical Center — Cape Girardeau, Missouri, United States
Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
Parkland Health Center - Farmington — Farmington, Missouri, United States
University Health Truman Medical Center — Kansas City, Missouri, United States
University of Kansas Cancer Center - Briarcliff — Kansas City, Missouri, United States
Kansas City Veterans Affairs Medical Center — Kansas City, Missouri, United States
University of Kansas Cancer Center - North — Kansas City, Missouri, United States
University of Kansas Cancer Center - Lee's Summit — Lee's Summit, Missouri, United States
Lake Regional Hospital — Osage Beach, Missouri, United States
Sainte Genevieve County Memorial Hospital — Sainte Genevieve, Missouri, United States
Washington University School of Medicine — St Louis, Missouri, United States
Veteran's Affairs Medical Center - Saint Louis — St Louis, Missouri, United States
Mercy Hospital South — St Louis, Missouri, United States
Siteman Cancer Center-South County — St Louis, Missouri, United States
Missouri Baptist Medical Center — St Louis, Missouri, United States
Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
Missouri Baptist Sullivan Hospital — Sullivan, Missouri, United States
Community Hospital of Anaconda — Anaconda, Montana, United States
Billings Clinic Cancer Center — Billings, Montana, United States
Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
Benefis Sletten Cancer Institute — Great Falls, Montana, United States
Logan Health Medical Center — Kalispell, Montana, United States
Community Medical Center — Missoula, Montana, United States
New Hampshire Oncology Hematology PA-Concord — Concord, New Hampshire, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center — Lebanon, New Hampshire, United States
Solinsky Center for Cancer Care — Manchester, New Hampshire, United States
Virtua Samson Cancer Center — Moorestown, New Jersey, United States
Virtua Voorhees — Voorhees Township, New Jersey, United States
University of New Mexico Cancer Center — Albuquerque, New Mexico, United States
The Cancer Institute at Saint Francis Hospital — East Hills, New York, United States
University of Rochester — Rochester, New York, United States
Stony Brook University Medical Center — Stony Brook, New York, United States
Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
James J Peters VA Medical Center — The Bronx, New York, United States
Wilmot Cancer Institute at Webster — Webster, New York, United States
Good Samaritan University Hospital — West Islip, New York, United States
Durham VA Medical Center — Durham, North Carolina, United States
FirstHealth of the Carolinas-Moore Regional Hospital — Pinehurst, North Carolina, United States
Sanford Bismarck Medical Center — Bismarck, North Dakota, United States
Essentia Health Cancer Center-South University Clinic — Fargo, North Dakota, United States
Sanford Broadway Medical Center — Fargo, North Dakota, United States
Sanford Roger Maris Cancer Center — Fargo, North Dakota, United States
OhioHealth O'Bleness Hospital — Athens, Ohio, United States
Aultman Health Foundation — Canton, Ohio, United States
Miami Valley Hospital South — Centerville, Ohio, United States
Louis Stokes Cleveland VA Medical Center — Cleveland, Ohio, United States
Columbus Oncology and Hematology Associates Inc — Columbus, Ohio, United States
Riverside Methodist Hospital — Columbus, Ohio, United States
Grant Medical Center — Columbus, Ohio, United States
Doctors Hospital — Columbus, Ohio, United States
Miami Valley Hospital — Dayton, Ohio, United States
Premier Blood and Cancer Center — Dayton, Ohio, United States
Miami Valley Hospital North — Dayton, Ohio, United States
Delaware Health Center-Grady Cancer Center — Delaware, Ohio, United States
Grady Memorial Hospital — Delaware, Ohio, United States
Columbus Oncology and Hematology Associates — Dublin, Ohio, United States
Dublin Methodist Hospital — Dublin, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
Miami Valley Cancer Care and Infusion — Greenville, Ohio, United States
OhioHealth Mansfield Hospital — Mansfield, Ohio, United States
OhioHealth Marion General Hospital — Marion, Ohio, United States
OhioHealth Pickerington Methodist Hospital — Pickerington, Ohio, United States
ProMedica Flower Hospital — Sylvania, Ohio, United States
Upper Valley Medical Center — Troy, Ohio, United States
OhioHealth Westerville Medical Campus/Westerville Cancer Center — Westerville, Ohio, United States
Cancer Centers of Southwest Oklahoma Research — Lawton, Oklahoma, United States
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
Integris Southwest Medical Center — Oklahoma City, Oklahoma, United States
Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
Saint Alphonsus Cancer Care Center-Baker City — Baker City, Oregon, United States
Providence Newberg Medical Center — Newberg, Oregon, United States
Saint Alphonsus Cancer Care Center-Ontario — Ontario, Oregon, United States
Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
Providence Portland Medical Center — Portland, Oregon, United States
Providence Saint Vincent Medical Center — Portland, Oregon, United States
Kaiser Permanente Northwest — Portland, Oregon, United States
Oregon Health and Science University — Portland, Oregon, United States
Salem Hospital — Salem, Oregon, United States
UPMC-Heritage Valley Health System Beaver — Beaver, Pennsylvania, United States
UPMC Hillman Cancer Center at Butler Health System — Butler, Pennsylvania, United States
WellSpan Medical Oncology and Hematology — Chambersburg, Pennsylvania, United States
UPMC Hillman Cancer Center - Passavant - Cranberry — Cranberry Township, Pennsylvania, United States
Ephrata Cancer Center — Ephrata, Pennsylvania, United States
UPMC Hillman Cancer Center Erie — Erie, Pennsylvania, United States
UPMC Cancer Center at UPMC Horizon — Farrell, Pennsylvania, United States
Adams Cancer Center — Gettysburg, Pennsylvania, United States
UPMC Cancer Centers - Arnold Palmer Pavilion — Greensburg, Pennsylvania, United States
WellSpan Medical Oncology and Hematology — Hanover, Pennsylvania, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus — Harrisburg, Pennsylvania, United States
IRMC Cancer Center — Indiana, Pennsylvania, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center — Johnstown, Pennsylvania, United States
Sechler Family Cancer Center — Lebanon, Pennsylvania, United States
UPMC Cancer Center at UPMC McKeesport — McKeesport, Pennsylvania, United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion — Mechanicsburg, Pennsylvania, United States
UPMC Hillman Cancer Center - Monroeville — Monroeville, Pennsylvania, United States
UPMC Hillman Cancer Center in Coraopolis — Moon Township, Pennsylvania, United States
UPMC Hillman Cancer Center - Part of Frick Hospital — Mount Pleasant, Pennsylvania, United States
Arnold Palmer Cancer Center Medical Oncology Norwin — N. Huntingdon, Pennsylvania, United States
UPMC Cancer Center-Natrona Heights — Natrona Heights, Pennsylvania, United States
UPMC Hillman Cancer Center - New Castle — New Castle, Pennsylvania, United States
University of Pennsylvania/Abramson Cancer Center — Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
Temple University Hospital — Philadelphia, Pennsylvania, United States
UPMC-Saint Margaret — Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
UPMC-Passavant Hospital — Pittsburgh, Pennsylvania, United States
UPMC-Saint Clair Hospital Cancer Center — Pittsburgh, Pennsylvania, United States
UPMC Cancer Center at UPMC Northwest — Seneca, Pennsylvania, United States
UPMC Cancer Center-Uniontown — Uniontown, Pennsylvania, United States
UPMC Cancer Center-Washington — Washington, Pennsylvania, United States
UPMC Susquehanna — Williamsport, Pennsylvania, United States
Divine Providence Hospital — Williamsport, Pennsylvania, United States
Cancer Care Associates of York — York, Pennsylvania, United States
AnMed Health Cancer Center — Anderson, South Carolina, United States
Saint Joseph's/Candler - Bluffton Campus — Bluffton, South Carolina, United States
Medical University of South Carolina — Charleston, South Carolina, United States
Gibbs Cancer Center-Gaffney — Gaffney, South Carolina, United States
Gibbs Cancer Center-Pelham — Greer, South Carolina, United States
South Carolina Cancer Specialists PC — Hilton Head Island, South Carolina, United States
Spartanburg Medical Center — Spartanburg, South Carolina, United States
SMC Center for Hematology Oncology Union — Union, South Carolina, United States
Rapid City Regional Hospital — Rapid City, South Dakota, United States
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota, United States
Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota, United States
Baptist Memorial Hospital and Cancer Center-Collierville — Collierville, Tennessee, United States
Baptist Memorial Hospital and Cancer Center-Memphis — Memphis, Tennessee, United States
The Don and Sybil Harrington Cancer Center — Amarillo, Texas, United States
Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
Dartmouth Cancer Center - North — Saint Johnsbury, Vermont, United States
White River Junction Veteran Administration Medical Center — White River Junction, Vermont, United States
University of Virginia Cancer Center — Charlottesville, Virginia, United States
Centra Alan B Pearson Regional Cancer Center — Lynchburg, Virginia, United States
Kaiser Permanente Tysons Corner Medical Center — McLean, Virginia, United States
Virginia Cancer Institute — Richmond, Virginia, United States
VCU Massey Cancer Center at Stony Point — Richmond, Virginia, United States
VCU Massey Comprehensive Cancer Center — Richmond, Virginia, United States
VCU Community Memorial Health Center — South Hill, Virginia, United States
Kaiser Permanente-Caton Hill Medical Center — Woodbridge, Virginia, United States
United Hospital Center — Bridgeport, West Virginia, United States
Edwards Comprehensive Cancer Center — Huntington, West Virginia, United States
WVUH-Berkely Medical Center — Martinsburg, West Virginia, United States
West Virginia University Healthcare — Morgantown, West Virginia, United States
Camden Clark Medical Center — Parkersburg, West Virginia, United States
Wheeling Hospital/Schiffler Cancer Center — Wheeling, West Virginia, United States
Duluth Clinic Ashland — Ashland, Wisconsin, United States
Aurora Cancer Care-Southern Lakes VLCC — Burlington, Wisconsin, United States
Aurora Saint Luke's South Shore — Cudahy, Wisconsin, United States
Aurora Health Care Germantown Health Center — Germantown, Wisconsin, United States
Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Saint Mary's — Green Bay, Wisconsin, United States
Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
Aurora Cancer Care-Kenosha South — Kenosha, Wisconsin, United States
Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center — Madison, Wisconsin, United States
University of Wisconsin Carbone Cancer Center - University Hospital — Madison, Wisconsin, United States
Aurora Bay Area Medical Group-Marinette — Marinette, Wisconsin, United States
Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
Aurora Cancer Care-Milwaukee — Milwaukee, Wisconsin, United States
Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States
Aurora Sinai Medical Center — Milwaukee, Wisconsin, United States
Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Oconto Falls — Oconto Falls, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin, United States
Aurora Cancer Care-Racine — Racine, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sheboygan — Sheboygan, Wisconsin, United States
Sheboygan Physicians Group — Sheboygan, Wisconsin, United States
Vince Lombardi Cancer Clinic-Sheboygan — Sheboygan, Wisconsin, United States
Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay — Sturgeon Bay, Wisconsin, United States
Aurora Medical Center in Summit — Summit, Wisconsin, United States
Vince Lombardi Cancer Clinic-Two Rivers — Two Rivers, Wisconsin, United States
Aurora Cancer Care-Milwaukee West — Wauwatosa, Wisconsin, United States
Aurora West Allis Medical Center — West Allis, Wisconsin, United States
Marshfield Medical Center - Weston — Weston, Wisconsin, United States

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record

Accelerate Your Clinical Trial Recruitment