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RECRUITING Not applicable ClinicalTrials.gov

Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective Regimens

Sponsor: CHU de Reims • ClinicalTrials.gov ID: NCT06554327

Registry updated: 2026-09-03
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Description

Ventilator-associated pneumonia (VAP) remains one of the main nosocomial infections acquired in the intensive care unit (ICU). VAP is pneumonia occurring 48 hours after intubation. Today, bronchoalveolar lavage (BAL) is used for microbiological diagnosis, with bacterial culture and antibiotic susceptibility results within 48 to 72 hours. Multiplex PCR can detect DNA of a number of bacteriae, as well as the presence of resistance genes. However, its clinical value in the ICU remains to be demonstrated. We think that the use of multiplex PCR with a panel adapted to the microbiology of VAP, could be an interesting method for clinicians in ICU.

Interventions

  • Multiplex PCR (Device)
    In the intervention group (Multiplex PCR performed and results communicated to the clinician), bronchoalveolar lavage will be examined directly after Gram staining by the laboratory, followed by quantitative culture. A multiplex PCR will be performed.

Eligibility criteria

inclusion criteria : * Adult patients, hospitalized in intensive care unit * on mechanical ventilation for at least 48 hours * Suspected VAP * With an indication for bronchoalveolar lavage (BAL) exclusion criteria : * Patients under legal protection or without social security coverage * Pregnant women * Previous episode of VAP during the same hospitalization

Conditions

Ventilator Associated Pneumonia

Locations

  • Damien JOLLY — Reims, France
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record