Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers
Sponsor: Emory University • ClinicalTrials.gov ID: NCT06492070
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The phase II trial evaluates the effectiveness of cryocompression therapy alone or in combination with cilostazol in preventing paclitaxel-induced peripheral neuropathy (numbness, pain or tingling in the feet and hands) for patients with gynecologic cancers. Peripheral neuropathy is a common side effect of many chemotherapeutic agents, including paclitaxel. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Cryocompression is a therapy that combines compression garments or dressings with cooling of the treated area. Cilostazol is in a class of medications called platelet-aggregation inhibitors (antiplatelet medications). It works by improving blood flow to the legs. Giving cilostazol together with cryocompression may be safe and tolerable in treating patients with gynecological cancers.
Interventions
-
Best Practice
(Other)
Undergo standard of care
-
Cilostazol
(Drug)
Given PO
-
Cryocompression Therapy
(Device)
Undergo cryocompression therapy
-
Paclitaxel
(Drug)
Given by infusion
-
Quality-of-Life Assessment
(Other)
Ancillary studies
Eligibility criteria
Conditions
Locations
- Emory University Hospital Midtown — Atlanta, Georgia, United States
- Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
- Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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