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RECRUITING Phase 3 ClinicalTrials.gov

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

Sponsor: ECOG-ACRIN Cancer Research Group • ClinicalTrials.gov ID: NCT06475989

Registry updated: 2026-09-24
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Description

This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth of tumor cells and blood vessels the tumor needs to survive. Dabrafenib is an enzyme inhibitor that binds to and inhibits the activity of a protein called B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. Trametinib is also an enzyme inhibitor. It binds to and inhibits the activity of proteins called MEK 1 and 2, which play a key role in activating pathways that regulate cell growth. This may inhibit the growth of tumor cells mediated by these pathways. The usual approach for patients with thyroid cancer is targeted therapy with dabrafenib and trametinib. This trial may help researchers decide which treatment option (cabozantinib alone or dabrafenib in combination with trametinib) is safer and/or more effective in treating patients with refractory BRAF V600E-mutated differentiated thyroid cancer.

Interventions

  • Biospecimen Collection (Procedure)
    Undergo blood sample collection
  • Cabozantinib (Drug)
    Given PO
  • Computed Tomography (Procedure)
    Undergo CT scan
  • Dabrafenib (Drug)
    Given PO
  • Magnetic Resonance Imaging (Procedure)
    Undergo MRI
  • Questionnaire Administration (Other)
    Ancillary study
  • Trametinib (Drug)
    Given PO

Eligibility criteria

Inclusion Criteria: * Patient must be ≥ 18 years of age * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Patient must have differentiated thyroid cancer (DTC) with BRAF V600E mutation as determined by local testing, including the following subtypes (Note: results of a previous biopsy will be accepted): * Papillary thyroid carcinoma including histological variants of papillary thyroid carcinoma (PTC) such as follicular variant, tall cell, columnar cell, cribriform-morular, solid, oxyphil, Warthin-like, trabecular, tumor with nodular fasciitis-like stroma, Hürthle cell variant of papillary carcinoma, poorly differentiated. * Follicular thyroid carcinoma including histological variants of follicular thyroid carcinoma (FTC) such as Hürthle cell, clear cell, insular, and poorly differentiated * Patient must have been previously treated with or deemed ineligible for treatment with Iodine-131 for DTC, and must be receiving thyroxine suppression therapy * Patient must have had prior treatment with at least one of the following vascular endothelial growth factor receptors (VEGFR)-targeting tyrosine kinase inhibitor (TKI) agents for DTC: lenvatinib or sorafenib. * NOTE: Up to two prior VEGFR-targeting TKI agents are allowed including, but not limited to lenvatinib and sorafenib * Patient must have measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) 1·1 on chest CT (computed tomography)/abdominal/pelvis CT/MRI (magnetic resonance imaging) performed within 4 weeks prior to randomization * Patient must have radiographic progression by RECIST 1.1 over any time interval on or after most recent prior systemic treatment * Patient must not have any of the following cardiovascular and thromboembolic disorders or medical conditions: * Congestive heart failure class 3 or 4 as defined by the New York Heart Association, unstable angina pectoris, or serious cardiac arrhythmias. * Uncontrolled hypertension defined as sustained blood pressure \> 150 mm Hg systolic or \> 100 mm Hg diastolic despite optimal antihypertensive treatment. * Stroke, myocardial infarction, or thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 6 months prior to randomization. Patients with more recent diagnosis of deep venous thrombosis are allowed if stable and treated with therapeutic anticoagulation for at least 6 weeks prior to randomization * Patient must not have any clinically significant hematemesis or haemoptysis of \> 0·5 teaspoon (\> 2·5 mL) of red blood or history of other significant bleeding within 3 months prior to randomization * Patient must not have any cavitating pulmonary lesion(s) or lesions invading major pulmonary blood vessels * Patient must not be on any concomitant anticoagulation with oral anticoagulants or platelet inhibitors, except for the following allowed agents: * Low-dose aspirin for cardioprotection. * Therapeutic anticoagulation with any agent in patients (1) without known brain metastases, (2) on a stable dose for at least 6 weeks prior to randomization, and (3) with no clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor * Patient must not have any gastrointestinal (GI) disorders associated with a high risk of perforation or fistula formation: * Tumors invading the GI tract, active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis, diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis, acute pancreatitis, or acute obstruction of the pancreatic or biliary duct, or gastric outlet obstruction * Abdominal fistula, GI perforation, bowel obstruction, or intra-abdominal abscess within 6 months prior to randomization * Patient must have completed any prior local therapy (e.g., surgery, radiation, ablation) at least 4 weeks prior to randomization, with complete wound healing and resolution of clinically relevant complications from prior local therapy * Patient must not have had major surgery (e.g., GI surgery, removal or biopsy of brain metastasis) within 8 weeks prior to randomization. Complete wound healing from major surgery must have occurred 4 weeks prior to randomization and from minor surgery (e.g., simple excision, tooth extraction) at least 10 days prior to randomization * Patient must not have pathologically documented anaplastic histology or transformation on any recurrence specimen collected after initial thyroidectomy/neck dissection * Patient must not have had prior treatment with cabozantinib or any prior BRAF targeted therapy for thyroid cancer * NOTE: Prior treatment with checkpoint inhibitor (e.g., pembrolizumab) for thyroid cancer is allowed, but must be noted on the eCRF (electronic case report form) * Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A patient of childbearing potential is defined as someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and for 2 weeks after the last dose of dabrafenib and 4 months after the last dose of trametinib or cabozantinib. Patients must also not breastfeed while on study treatment and for 2 weeks after the last dose of dabrafenib and for 4 months after the last dose of trametinib or cabozantinib. * NOTE: Patients of childbearing potential who are on hormonal contraceptives may be at risks because dabrafenib may decrease the efficacy of hormonal contraceptives. An effective non-hormonal contraception should be used during therapy and for 2 weeks following discontinuation of dabrafenib and at least 4 months following the last dose of trametinib and cabozantinib * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Hemoglobin (Hgb) ≥ 8 g/dL obtained ≤ 28 days prior to protocol randomization * Leukocytes ≥ 3,000/mcL obtained ≤ 28 days prior to protocol randomization * Absolute neutrophil count (ANC) ≥ 1,500/mcL obtained ≤ 28 days prior to protocol randomization * Platelets ≥ 100,000/mcL obtained ≤ 28 days prior to protocol randomization * Total bilirubin ≤ 2.0 x institutional upper limit of normal (ULN) obtained ≤ 28 days prior to protocol randomization * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase \[SGPT\]) ≤ 3.0 × institutional ULN or \< 5.0 x ULN with the presence of hepatic metastasis obtained ≤ 28 days prior to protocol randomization * Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m² obtained ≤ 28 days prior to protocol randomization * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patients with treated brain metastases are eligible if follow-up brain imaging obtained after central nervous system (CNS)-directed therapy (radiotherapy and/or surgery) shows no evidence of progression. CNS disease must be stable for at least 4 weeks prior to randomization; patients must be neurologically asymptomatic and without corticosteroid treatment at time of randomization * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Patients must have corrected QT interval calculated by the Fridericia formula (QTcF) ≤ 500 ms obtained within 28 days prior to randomization. * NOTE: If a single electrocardiogram (ECG) shows a QTcF with an absolute value \> 500 ms, two additional ECGs at intervals of approximately 3 minutes (min) must be performed within 30 min after the initial ECG, and the average of these 3 consecutive results for QTcF will be used to determine eligibility * Patient must be English or Spanish speaking to be eligible for the quality of life (QOL) component of the study. * NOTE: Sites cannot translate the associated QOL forms

Conditions

Refractory Differentiated Thyroid Gland Carcinoma

Locations

  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
  • Anchorage Radiation Therapy Center — Anchorage, Alaska, United States
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
  • Alaska Women's Cancer Care — Anchorage, Alaska, United States
  • Katmai Oncology Group — Anchorage, Alaska, United States
  • Providence Alaska Medical Center — Anchorage, Alaska, United States
  • Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
  • Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
  • CARTI Cancer Center — Little Rock, Arkansas, United States
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California, United States
  • Providence Queen of The Valley — Napa, California, United States
  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California, United States
  • Stanford Cancer Institute Palo Alto — Palo Alto, California, United States
  • Providence Medical Foundation - Santa Rosa — Santa Rosa, California, United States
  • Providence Santa Rosa Memorial Hospital — Santa Rosa, California, United States
  • UCHealth University of Colorado Hospital — Aurora, Colorado, United States
  • UCHealth Highlands Ranch Hospital — Highlands Ranch, Colorado, United States
  • Smilow Cancer Hospital-Derby Care Center — Derby, Connecticut, United States
  • Smilow Cancer Hospital Care Center-Fairfield — Fairfield, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Glastonbury — Glastonbury, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Greenwich — Greenwich, Connecticut, United States
  • Smilow Cancer Hospital Care Center - Guilford — Guilford, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut, United States
  • Smilow Cancer Center/Yale-New Haven Hospital — New Haven, Connecticut, United States
  • Yale University — New Haven, Connecticut, United States
  • Yale-New Haven Hospital North Haven Medical Center — North Haven, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Long Ridge — Stamford, Connecticut, United States
  • Smilow Cancer Hospital-Torrington Care Center — Torrington, Connecticut, United States
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull, Connecticut, United States
  • Smilow Cancer Hospital-Waterbury Care Center — Waterbury, Connecticut, United States
  • Smilow Cancer Hospital Care Center - Waterford — Waterford, Connecticut, United States
  • Holy Cross Hospital — Fort Lauderdale, Florida, United States
  • Mayo Clinic in Florida — Jacksonville, Florida, United States
  • Emory University Hospital Midtown — Atlanta, Georgia, United States
  • Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
  • Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
  • Walter Knox Memorial Hospital — Emmett, Idaho, United States
  • Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
  • Idaho Urologic Institute-Meridian — Meridian, Idaho, United States
  • Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Kootenai Clinic Cancer Services - Sandpoint — Sandpoint, Idaho, United States
  • Saint Luke's Cancer Institute - Twin Falls — Twin Falls, Idaho, United States
  • OSF Saint Anthony's Health Center — Alton, Illinois, United States
  • Advocate Outpatient Center - Aurora — Aurora, Illinois, United States
  • Advocate Good Shepherd Hospital — Barrington, Illinois, United States
  • Saint Mary's Hospital — Centralia, Illinois, United States
  • Northwestern University — Chicago, Illinois, United States
  • University of Illinois — Chicago, Illinois, United States
  • University of Chicago Comprehensive Cancer Center — Chicago, Illinois, United States
  • Advocate Illinois Masonic Medical Center — Chicago, Illinois, United States
  • AMG Crystal Lake - Oncology — Crystal Lake, Illinois, United States
  • Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
  • Advocate Good Samaritan Hospital — Downers Grove, Illinois, United States
  • Advocate Sherman Hospital — Elgin, Illinois, United States
  • Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
  • Northwestern Medicine Glenview Outpatient Center — Glenview, Illinois, United States
  • Northwestern Medicine Grayslake Outpatient Center — Grayslake, Illinois, United States
  • Advocate South Suburban Hospital — Hazel Crest, Illinois, United States
  • Northwestern Medicine Lake Forest Hospital — Lake Forest, Illinois, United States
  • AMG Libertyville - Oncology — Libertyville, Illinois, United States
  • Condell Memorial Hospital — Libertyville, Illinois, United States
  • SSM Health Good Samaritan — Mount Vernon, Illinois, United States
  • UC Comprehensive Cancer Center at Silver Cross — New Lenox, Illinois, United States
  • Advocate Christ Medical Center — Oak Lawn, Illinois, United States
  • Advocate Outpatient Center - Oak Lawn — Oak Lawn, Illinois, United States
  • Northwestern Medicine Orland Park — Orland Park, Illinois, United States
  • University of Chicago Medicine-Orland Park — Orland Park, Illinois, United States
  • Advocate High Tech Medical Park — Palos Heights, Illinois, United States
  • Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
  • Memorial Hospital East — Shiloh, Illinois, United States
  • Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
  • UChicago Medicine Northwest Indiana — Crown Point, Indiana, United States
  • UI Health Care Mission Cancer and Blood - Ankeny Clinic — Ankeny, Iowa, United States
  • University of Iowa Healthcare Cancer Services Quad Cities — Bettendorf, Iowa, United States
  • Saint Anthony Regional Hospital — Carroll, Iowa, United States
  • Mercy Hospital — Cedar Rapids, Iowa, United States
  • Oncology Associates at Mercy Medical Center — Cedar Rapids, Iowa, United States
  • Mercy Cancer Center-West Lakes — Clive, Iowa, United States
  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic — Clive, Iowa, United States
  • Heartland Oncology and Hematology LLP — Council Bluffs, Iowa, United States
  • Methodist Jennie Edmundson Hospital — Council Bluffs, Iowa, United States
  • Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ — Council Bluffs, Iowa, United States
  • Greater Regional Medical Center — Creston, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Des Moines Clinic — Des Moines, Iowa, United States
  • Broadlawns Medical Center — Des Moines, Iowa, United States
  • Mercy Medical Center - Des Moines — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Laurel Clinic — Des Moines, Iowa, United States
  • UI Healthcare Mission Cancer and Blood - Fort Dodge — Fort Dodge, Iowa, United States
  • University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
  • UI Healthcare Mission Cancer and Blood - Pella — Pella, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Waukee Clinic — Waukee, Iowa, United States
  • Mercy Medical Center-West Lakes — West Des Moines, Iowa, United States
  • The Iowa Clinic PC — West Des Moines, Iowa, United States
  • Central Care Cancer Center - Garden City — Garden City, Kansas, United States
  • Central Care Cancer Center - Great Bend — Great Bend, Kansas, United States
  • Mercy Hospital Pittsburg — Pittsburg, Kansas, United States
  • University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland, United States
  • MyMichigan Medical Center Gratiot — Alma, Michigan, United States
  • MyMichigan Medical Center Alpena — Alpena, Michigan, United States
  • Trinity Health IHA - Obstetrics and Gynecology West Arbor — Ann Arbor, Michigan, United States
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor — Ann Arbor, Michigan, United States
  • University of Michigan Rogel Cancer Center — Ann Arbor, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan, United States
  • Trinity Health Medical Center - Brighton — Brighton, Michigan, United States
  • University of Michigan - Brighton Center for Specialty Care — Brighton, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Canton — Canton, Michigan, United States
  • Trinity Health Medical Center - Canton — Canton, Michigan, United States
  • Caro Cancer Center — Caro, Michigan, United States
  • Chelsea Hospital — Chelsea, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital — Chelsea, Michigan, United States
  • Hematology Oncology Consultants-Clarkston — Clarkston, Michigan, United States
  • Newland Medical Associates-Clarkston — Clarkston, Michigan, United States
  • Trinity Health IHA Medical Group - Primary Care - Clarkston — Clarkston, Michigan, United States
  • Henry Ford Health Saint John Hospital — Detroit, Michigan, United States
  • Henry Ford River District Hospital — East China, Michigan, United States
  • Cancer Hematology Centers - Flint — Flint, Michigan, United States
  • Genesee Hematology Oncology PC — Flint, Michigan, United States
  • Genesys Hurley Cancer Institute — Flint, Michigan, United States
  • Hurley Medical Center — Flint, Michigan, United States
  • MyMichigan Medical Center Gladwin — Gladwin, Michigan, United States
  • Trinity Health Grand Rapids Hospital — Grand Rapids, Michigan, United States
  • Henry Ford Saint John Hospital - Academic — Grosse Pointe Woods, Michigan, United States
  • Henry Ford Saint John Hospital - Breast — Grosse Pointe Woods, Michigan, United States
  • Henry Ford Saint John Hospital - Van Elslander — Grosse Pointe Woods, Michigan, United States
  • University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
  • Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
  • Henry Ford Saint John Hospital - Macomb Medical — Macomb, Michigan, United States
  • Henry Ford Warren Hospital - Breast Macomb — Macomb, Michigan, United States
  • Saint Mary's Oncology/Hematology Associates of Marlette — Marlette, Michigan, United States
  • MyMichigan Medical Center Midland — Midland, Michigan, United States
  • MyMichigan Medical Center Mount Pleasant — Mount Pleasant, Michigan, United States
  • Trinity Health Muskegon Hospital — Muskegon, Michigan, United States
  • Cancer and Hematology Centers of Western Michigan - Norton Shores — Norton Shores, Michigan, United States
  • Hope Cancer Center — Pontiac, Michigan, United States
  • Michigan Healthcare Professionals Pontiac — Pontiac, Michigan, United States
  • Newland Medical Associates-Pontiac — Pontiac, Michigan, United States
  • Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
  • MyMichigan Medical Center Saginaw — Saginaw, Michigan, United States
  • Oncology Hematology Associates of Saginaw Valley PC — Saginaw, Michigan, United States
  • MyMichigan Medical Center Tawas — Tawas City, Michigan, United States
  • Henry Ford Health Warren Hospital — Warren, Michigan, United States
  • Henry Ford Madison Heights Hospital - Breast — Warren, Michigan, United States
  • Henry Ford Warren Hospital - GLCMS — Warren, Michigan, United States
  • Saint Mary's Oncology/Hematology Associates of West Branch — West Branch, Michigan, United States
  • Huron Gastroenterology PC — Ypsilanti, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan, United States
  • Sanford Joe Lueken Cancer Center — Bemidji, Minnesota, United States
  • Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
  • Cambridge Medical Center — Cambridge, Minnesota, United States
  • Minnesota Oncology Hematology PA-Chaska — Chaska, Minnesota, United States
  • Mercy Hospital — Coon Rapids, Minnesota, United States
  • Minnesota Oncology - Coon Rapids — Coon Rapids, Minnesota, United States
  • Fairview Southdale Hospital — Edina, Minnesota, United States
  • Minnesota Oncology - Edina — Edina, Minnesota, United States
  • Fairview Clinics and Surgery Center Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology - Maple Grove — Maple Grove, Minnesota, United States
  • Minnesota Oncology Hematology PA-Maplewood — Maplewood, Minnesota, United States
  • Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
  • Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
  • Hennepin County Medical Center — Minneapolis, Minnesota, United States
  • Health Partners Inc — Minneapolis, Minnesota, United States
  • Monticello Cancer Center — Monticello, Minnesota, United States
  • New Ulm Medical Center — New Ulm, Minnesota, United States
  • Fairview Northland Medical Center — Princeton, Minnesota, United States
  • North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
  • Mayo Clinic in Rochester — Rochester, Minnesota, United States
  • Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • United Hospital — Saint Paul, Minnesota, United States
  • Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
  • Lakeview Hospital — Stillwater, Minnesota, United States
  • Sanford Thief River Falls Medical Center — Thief River Falls, Minnesota, United States
  • Ridgeview Medical Center — Waconia, Minnesota, United States
  • Rice Memorial Hospital — Willmar, Minnesota, United States
  • Minnesota Oncology Hematology PA-Woodbury — Woodbury, Minnesota, United States
  • Sanford Cancer Center Worthington — Worthington, Minnesota, United States
  • Fairview Lakes Medical Center — Wyoming, Minnesota, United States
  • Mercy Oncology and Hematology - Clayton-Clarkson — Ballwin, Missouri, United States
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri, United States
  • Cox Cancer Center Branson — Branson, Missouri, United States
  • Mercy Cancer Center - Cape Girardeau — Cape Girardeau, Missouri, United States
  • Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
  • Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
  • Freeman Health System — Joplin, Missouri, United States
  • Mercy Hospital Joplin — Joplin, Missouri, United States
  • Lake Regional Hospital — Osage Beach, Missouri, United States
  • Mercy Clinic-Rolla-Cancer and Hematology — Rolla, Missouri, United States
  • Phelps Health Delbert Day Cancer Institute — Rolla, Missouri, United States
  • Heartland Regional Medical Center — Saint Joseph, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • CoxHealth South Hospital — Springfield, Missouri, United States
  • Mercy Infusion Center - Chippewa — St Louis, Missouri, United States
  • Washington University School of Medicine — St Louis, Missouri, United States
  • Mercy Hospital South — St Louis, Missouri, United States
  • Siteman Cancer Center-South County — St Louis, Missouri, United States
  • Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Mercy Hospital Washington — Washington, Missouri, United States
  • Community Hospital of Anaconda — Anaconda, Montana, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
  • Benefis Sletten Cancer Institute — Great Falls, Montana, United States
  • Great Falls Clinic — Great Falls, Montana, United States
  • Hi-Line Sletten Cancer Center — Havre, Montana, United States
  • Benefis Helena Specialty Center — Helena, Montana, United States
  • Logan Health Medical Center — Kalispell, Montana, United States
  • Saint Patrick Hospital - Community Hospital — Missoula, Montana, United States
  • Community Medical Center — Missoula, Montana, United States
  • Nebraska Cancer Specialists/Oncology Hematology West PC - MECC — Omaha, Nebraska, United States
  • Nebraska Methodist Hospital — Omaha, Nebraska, United States
  • Oncology Associates PC — Omaha, Nebraska, United States
  • Duke Cancer Center Cary — Cary, North Carolina, United States
  • UNC Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina, United States
  • Duke University Medical Center — Durham, North Carolina, United States
  • Duke Cancer Center Raleigh — Raleigh, North Carolina, United States
  • Sanford Bismarck Medical Center — Bismarck, North Dakota, United States
  • Sanford South University Medical Center — Fargo, North Dakota, United States
  • Southpointe-Sanford Medical Center Fargo — Fargo, North Dakota, United States
  • Sanford Medical Center Fargo — Fargo, North Dakota, United States
  • Sanford Broadway Medical Center — Fargo, North Dakota, United States
  • Sanford Roger Maris Cancer Center — Fargo, North Dakota, United States
  • Cancer Centers of Southwest Oklahoma Research — Lawton, Oklahoma, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
  • Saint Alphonsus Cancer Care Center-Baker City — Baker City, Oregon, United States
  • Saint Charles Health System — Bend, Oregon, United States
  • Clackamas Radiation Oncology Center — Clackamas, Oregon, United States
  • Providence Cancer Institute Clackamas Clinic — Clackamas, Oregon, United States
  • Bay Area Hospital — Coos Bay, Oregon, United States
  • Providence Hood River Memorial Hospital — Hood River, Oregon, United States
  • Providence Newberg Medical Center — Newberg, Oregon, United States
  • Saint Alphonsus Cancer Care Center-Ontario — Ontario, Oregon, United States
  • Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
  • Providence Portland Medical Center — Portland, Oregon, United States
  • Providence Saint Vincent Medical Center — Portland, Oregon, United States
  • Oregon Health and Science University — Portland, Oregon, United States
  • Saint Charles Health System-Redmond — Redmond, Oregon, United States
  • Lehigh Valley Hospital-Cedar Crest — Allentown, Pennsylvania, United States
  • Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania, United States
  • Pocono Medical Center — East Stroudsburg, Pennsylvania, United States
  • UPMC Hillman Cancer Center Erie — Erie, Pennsylvania, United States
  • Lehigh Valley Hospital-Hazleton — Hazleton, Pennsylvania, United States
  • University of Pennsylvania/Abramson Cancer Center — Philadelphia, Pennsylvania, United States
  • UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
  • Smilow Cancer Hospital Care Center - Westerly — Westerly, Rhode Island, United States
  • Medical University of South Carolina — Charleston, South Carolina, United States
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota, United States
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota, United States
  • Vanderbilt-Ingram Cancer Center Cool Springs — Franklin, Tennessee, United States
  • Vanderbilt Breast Center at One Hundred Oaks — Nashville, Tennessee, United States
  • Vanderbilt University/Ingram Cancer Center — Nashville, Tennessee, United States
  • Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
  • Providence Regional Cancer System-Aberdeen — Aberdeen, Washington, United States
  • PeaceHealth Saint Joseph Medical Center — Bellingham, Washington, United States
  • Providence Regional Cancer System-Centralia — Centralia, Washington, United States
  • Swedish Cancer Institute-Edmonds — Edmonds, Washington, United States
  • Providence Regional Cancer Partnership — Everett, Washington, United States
  • Swedish Cancer Institute-Issaquah — Issaquah, Washington, United States
  • Kadlec Clinic Hematology and Oncology — Kennewick, Washington, United States
  • Providence Regional Cancer System-Lacey — Lacey, Washington, United States
  • PeaceHealth Saint John Medical Center — Longview, Washington, United States
  • Skagit Regional Health Cancer Care Center — Mount Vernon, Washington, United States
  • Swedish Medical Center-Ballard Campus — Seattle, Washington, United States
  • Swedish Medical Center-Cherry Hill — Seattle, Washington, United States
  • Swedish Medical Center-First Hill — Seattle, Washington, United States
  • PeaceHealth United General Medical Center — Sedro-Woolley, Washington, United States
  • Cancer Care Northwest - Spokane South — Spokane, Washington, United States
  • Cancer Care Northwest-Valley — Spokane, Washington, United States
  • Cancer Care Northwest-North Spokane — Spokane, Washington, United States
  • PeaceHealth Southwest Medical Center — Vancouver, Washington, United States
  • Providence Saint Mary Regional Cancer Center — Walla Walla, Washington, United States
  • Aurora Cancer Care-Southern Lakes VLCC — Burlington, Wisconsin, United States
  • Aurora Saint Luke's South Shore — Cudahy, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • Aurora Health Care Germantown Health Center — Germantown, Wisconsin, United States
  • Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
  • Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
  • Aurora Cancer Care-Kenosha South — Kenosha, Wisconsin, United States
  • Aurora Bay Area Medical Group-Marinette — Marinette, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Aurora Cancer Care-Milwaukee — Milwaukee, Wisconsin, United States
  • Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States
  • Aurora Sinai Medical Center — Milwaukee, Wisconsin, United States
  • Marshfield Medical Center - Minocqua — Minocqua, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin, United States
  • Aurora Cancer Care-Racine — Racine, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Vince Lombardi Cancer Clinic-Sheboygan — Sheboygan, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Aurora Medical Center in Summit — Summit, Wisconsin, United States
  • Vince Lombardi Cancer Clinic-Two Rivers — Two Rivers, Wisconsin, United States
  • Aurora Cancer Care-Milwaukee West — Wauwatosa, Wisconsin, United States
  • Aurora West Allis Medical Center — West Allis, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
  • Memorial Hospital of Laramie County — Cheyenne, Wyoming, United States
  • Billings Clinic-Cody — Cody, Wyoming, United States
  • Welch Cancer Center — Sheridan, Wyoming, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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