RECRUITING Phase 3 ClinicalTrials.gov

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Sponsor: Bayer • ClinicalTrials.gov ID: NCT06452277

Registry updated: 2026-10-15

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Description

Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations. Advanced NSCLC means lung cancer that has spread nearby or to other parts of the body or is unlikely to be controlled with current treatments. HER2 is a protein that helps cells to grow and divide. Sometimes, cancer cells have a damaged HER2 gene. This is called a mutation. This mutation can lead to an abnormal HER2 protein which may cause cancer cells to grow and divide too quickly. The study treatment, sevabertinib, is designed to block the mutated HER2 protein and may help slow or stop the cancer from growing. The main purpose of this study is to find out how well sevabertinib works and how safe it is, compared with standard treatment in participants with advanced NSCLC with a HER2 mutation. The study participants will receive one of the study treatments: * Sevabertinib as a tablet taken by mouth twice a day * Standard approved treatment for this condition given by infusion into a vein every 21 days Participants will continue their assigned treatment for as long as they benefit from it and do not experience severe side effects, or until they or their doctor decide to stop treatment. When a participant assigned to the standard treatment has their cancer gets worse, they may have the opportunity to switch to receive sevabertinib. This switch is called a crossover. Participants who switch to sevabertinib will continue this treatment until their disease gets worse again, they have side effects that are too severe, or they or their doctor decide to stop treatment. During the study, the research team will: * do scans such as CT, PET, MRI, or X-rays to check the cancer * Check the overall health of the participants by performing tests such as blood and urine tests and checking heart health using an electrocardiogram and echocardiogram. * do pregnancy tests when needed * ask how the participants are feeling and whether they have had any adverse events or other health problems An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.

Interventions

Sevabertinib (Drug)
Tablet, oral
Pembrolizumab (Drug)
Intravenous (IV) infusion
Cisplatin (Drug)
IV infusion
Carboplatin (Drug)
IV infusion
Pemetrexed (Drug)
IV infusion

Eligibility criteria

Inclusion Criteria: * Participant must be ≥18 years of age or over the legal age of consent in countries where that is greater than 18 years at the time of signing the informed consent. * Documented histologically or cytologically confirmed locally advanced non-squamous NSCLC, not suitable for definitive therapy or metastatic non-squamous NSCLC at screening (small cell or mixed histologies are excluded) (Stage III-IV NSCLC). * Documented activating HER2 mutation in the tyrosine kinase domain (TKD) assessed by tissue molecular test in a CLIA-certified (US sites) or an equally accredited (outside of the US) local laboratory. However, participants may be included at the discretion of the investigator if the laboratory performing the assay is not CLIA or similar certified but the laboratory is locally accredited. * No prior systemic therapy for locally advanced or metastatic disease. No prior treatment with a HER2 ex20ins-targeted therapy (e.g. poziotinib, trastuzumab deruxtecan). Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 12 months prior to the start of screening. * Eligible to receive treatment with the selected platinum-based doublet-chemotherapy (i.e. cisplatin/pemetrexed or carboplatin/pemetrexed) and pembrolizumab in accordance with the SmPC/Product Information. Exclusion Criteria: * Known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for five years since initiation of that therapy. Exception: the following cancer types are acceptable within five years if curatively treated or under surveillance: * a. in situ cancers of cervix, breast, or skin, * b. superficial bladder cancer (Ta, Tis and T1), * c. limited-stage prostate cancer, * d. basal or squamous cancers of the skin. * Tumors with targetable alterations with approved available therapy, with the exception of HER2 mutation in the TKD. * Inability to discontinue treatment with chronic systemic corticosteroids. Participants who require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study. Replacement therapy (e.g., physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is acceptable, provided that the dose is stable for \>4 weeks prior to planned start of study intervention. * Pre-existing peripheral neuropathy that is Grade ≥2 by CTCAE (v5.0). * History of severe hypersensitivity reaction to treatment with a monoclonal antibody. * Prior radiotherapy outside of the brain within 21 days before of planned start of study intervention. Participants must have recovered from all radiation-related toxicities and not require corticosteroids.

Conditions

Advanced Non-small Cell Lung Cancer, HER2 Mutation

Locations

Patty & George Hoag Cancer Center — Newport Beach, California, United States
UC San Diego Health - Moores Cancer Center — San Diego, California, United States
UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology — San Francisco, California, United States
UCLA Health Santa Monica Cancer Care — Santa Monica, California, United States
The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street — Fort Lauderdale, Florida, United States
Memorial Cancer Institute at Miramar — Miramar, Florida, United States
AdventHealth Cancer Institute Orlando — Orlando, Florida, United States
Moffitt Cancer Center - Magnolia Campus — Tampa, Florida, United States
Piedmont Healthcare - Atlanta — Atlanta, Georgia, United States
John B. Amos Cancer Center — Columbus, Georgia, United States
University of Illinois Hospital - Outpatient Cancer Care Center — Chicago, Illinois, United States
The University of Chicago Medical Center - Hyde Park - Hematology & Oncology — Chicago, Illinois, United States
UM Greenebaum Comprehensive Cancer Center — Baltimore, Maryland, United States
UMass Memorial Medical Center - University Campus - Hematology/Oncology — Worcester, Massachusetts, United States
Profound Research -OMG - TriAtria Cancer Center — Farmington Hills, Michigan, United States
Profound Research - OMG - Royal Oak Cancer Center — Royal Oak, Michigan, United States
M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center — Minneapolis, Minnesota, United States
R.J. Zuckerberg Cancer Center — New Hyde Park, New York, United States
UC Medical Center - Oncology — Cincinnati, Ohio, United States
Taylor Cancer Research Center — Maumee, Ohio, United States
Providence Cancer Institute - Franz Clinic — Portland, Oregon, United States
Providence Oncology and Hematology Care Clinic Westside — Portland, Oregon, United States
Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
University Hospital Simmons Cancer Center Lung/Head Neck Clinic — Dallas, Texas, United States
The University of Texas MD Anderson Cancer Center - Texas Medical Center — Houston, Texas, United States
Instituto Argentino de Diagnostico y Tratamiento (IADT) — TBC, Buenos Aires, Argentina
Centro de Investigaciones Clínicas, Clínica Viedma — Viedma, Río Negro Province, Argentina
Fundación Cenit para la Investigación en Neurociencias — Buenos Aires, Argentina
Hospital Italiano de Buenos Aires — Buenos Aires, Argentina
Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC) — Buenos Aires, Argentina
Centro Médico Privado CEMAIC — Córdoba, Argentina
NSW Health - Blacktown Hospital — Blacktown, New South Wales, Australia
Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit — Concord, New South Wales, Australia
Calvary Mater Hospital Newcastle - Oncology — Waratah, New South Wales, Australia
University of the Sunshine Coast — Buderim, Queensland, Australia
Toowoomba Hospital Oncology Clinical Trials — Toowoomba, Queensland, Australia
Austin Hospital - Olivia Newton John Cancer Research Institute — Heidelberg, Victoria, Australia
Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III — Vienna, State of Salzburg, Austria
Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde — Vienna, State of Salzburg, Austria
Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie — Vienna, State of Vienna, Austria
Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik — Vienna, Austria
Antwerp University Hospital | Oncology Department — Antwerp, Antwerp, Belgium
UZ Leuven Gasthuisberg - Pneumology Department — Leuven, Flemish Brabant, Belgium
AZ Delta | Clinical Trial Center - Pneumology — Roeselare, West Flanders, Belgium
Pronutrir Fortaleza - CE — Fortaleza, Ceará, Brazil
Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima — Brasília, Federal District, Brazil
Rede DoR Recife - PE — Recife, Pernambuco, Brazil
Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica — Natal, Rio Grande do Norte, Brazil
Centro de Pesquisa da Clínica de Oncologia Reichow — Blumenau, Santa Catarina, Brazil
NAIC - Instituto do Cancer — Bauru, São Paulo, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos — Jaú, São Paulo, Brazil
Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia — São José do Rio Preto, São Paulo, Brazil
Hospital Sirio Libanes — São Paulo, Brazil
A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante — São Paulo, Brazil
Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia — São Paulo, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology — São Paulo, Brazil
MHAT Uni Hospital — Panagyurishte, Pazardzhik Province, Bulgaria
MHAT "Heart and brain" Pleven — Pleven, Pleven Province, Bulgaria
Complex Oncology Center - Plovdiv EOOD — Plovdiv, Plovdiv Province, Bulgaria
MHAT Park Hospital EOOD — Plovdiv, Plovdiv Province, Bulgaria
MHAT Serdikamed — Sofia, Sofia City Province, Bulgaria
Multiprofile Hospital for Active Treatment "Sveta Sofia" — Sofia, Sofia City Province, Bulgaria
Specialized Hospital for Active Treatment of Oncology — Sofia, Sofia City Province, Bulgaria
University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia — Sofia, Sofia City Province, Bulgaria
MHAT Sveta Marina EAD — Varna, Varna Province, Bulgaria
BC Cancer | Vancouver — Vancouver, British Columbia, Canada
Brampton Civic Hospital | Oncology — Brampton, Ontario, Canada
Princess Margaret Cancer Centre | Medical Oncology and Hematology — Toronto, Ontario, Canada
Jewish General Hospital | Pulmonary Oncology — Montreal, Quebec, Canada
Cancer Hospital, Chinese Academy of Medical Sciences — Beijing, Beijing Municipality, China
Beijing Cancer Hospital - Oncology Department — Beijing, Beijing Municipality, China
Beijing Hospital — Beijing, Beijing Municipality, China
The People's Liberation Army General Hospital (Beijing 301 Hospital) — Beijing, Beijing Municipality, China
Beijing chest hospital, Capital Medical University — Beijing, Beijing Municipality, China
Fujian Cancer Hospital — Fuzhou, Fujian, China
Xiamen University - The First Affiliated Hospital — Xiamen, Fujian, China
The first Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
Guangxi Medical University (GXMU) - Affiliated Tumor Hospital — Nanning, Guangxi, China
Harbin Medical University Cancer Hospital — Harbin, Heilongjiang, China
Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech — Wuhan, Hubei, China
Hubei Cancer Hospital — Wuhan, Hubei, China
Hunan Cancer Hospital - Oncology Department — Changsha, Hunan, China
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School — Nanjing, Jiangsu, China
Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China
Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province — Taizhou, Jiangsu, China
Jilin Cancer Hospital — Changchun, Jilin, China
Shandong University - Shandong Cancer Hospital — Jinan, Shandong, China
LinYi Cancer Hospital (Linyi Tumor Hospital) — Linyi, Shandong, China
Shanghai Chest Hospital, Shanghai Jiaotong University — Shanghai, Shanghai Municipality, China
Zhongshan Hospital, Fudan University — Shanghai, Shanghai Municipality, China
University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital) — Chengdu, Sichuan, China
West China Hospital Sichuan University — Chengdu, Sichuan, China
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department — Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital — Hangzhou, Zhejiang, China
Nemocnice AGEL Nový Jičín a.s. - Oddělení radioterapie a onkologie — Nový Jičín, Moravian-Silesian Region, Czechia
Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddělení — Ostrava - Vítkovice, Moravian-Silesian Region, Czechia
Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy — Olomouc, Olomouc Region, Czechia
Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP) — Brno, South Moravian, Czechia
Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie — Zlín, Zlín, Czechia
Rigshospitalet Copenhagen University Hospital | Oncology Department — Copenhagen, Capital Region / Region Hovedstaden, Denmark
Aarhus Universitetshospital — Aarhus N, Central Denmark Region / Region Midtjylland, Denmark
Regionshospitalet Gødstrup - Medicinsk afdeling — Herning, Central Denmark Region / Region Midtjylland, Denmark
Aalborg Universitetshospital - Onkologisk afdeling — Aalborg, North Denmark Region / Region Nordjylland, Denmark
Odense University Hospital | Svendborg Sygehus - Oncology Department — Odense, Region of Southern Denmark / Region Syddanmark, Denmark
Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Keuhkosairauksien poliklinikka — Turku, Southwest Finland, Finland
Docrates Mehiläinen Syöpäsairaala — Helsinki, Uusimaa, Finland
Centre Hospitalier Michallon Grenoble - Service pneumologie — La Tronche, Auvergne-Rhône-Alpes, France
hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique — Pierre-Bénite, Auvergne-Rhône-Alpes, France
Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie — Brest, Brittany Region, France
hopital Emile Muller - Service Pneumologie — Mulhouse, Grand Est, France
Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire — Lille, Hauts-de-France, France
Institut Bergonie - Unicancer Nouvelle Aquitaine — Bordeaux, New Aquitaine, France
Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique — Limoges, New Aquitaine, France
CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie — Rouen, Normandy, France
CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique — Montpellier, Occitanie, France
Hopital Nord Laennec - Oncologie medicale thoracique et digestive — Nantes, Pays de la Loire Region, France
Institut de Cancerologie Ouest - Saint-Herblain — Saint-Herblain, Pays de la Loire Region, France
Centre Antoine Lacassagne - Departement Oncologie — Nice, Provence-Alpes-Côte d'Azur Region, France
Centre Hospitalier Intercommunal Creteil - Service de pneumologie — Créteil, Île-de-France Region, France
APHP - Hopital Cochin - Service de Pneumologie — Paris, Île-de-France Region, France
Institut Curie - Paris - Oncologie medicale — Paris, Île-de-France Region, France
Hopital Foch - Oncologie digestive et thoracique — Suresnes, Île-de-France Region, France
Gustave Roussy - Departement Oncologie-Radiotherapie — Villejuif, Île-de-France Region, France
Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin — Stuttgart, Baden-Wurttemberg, Germany
Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde) — Nuremberg, Bavaria, Germany
Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie — Frankfurt am Main, Hesse, Germany
Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie — Giessen, Hesse, Germany
Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik — Cologne, North Rhine-Westphalia, Germany
Universitaetsklinikum Essen - Innere Klinik (Tumorforschung) — Essen, North Rhine-Westphalia, Germany
Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin — Hemer, North Rhine-Westphalia, Germany
Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie — Berlin, Germany
University General Hospital Attikon-4th Department of Internal Medicine — Chaïdári, Attica, Greece
Ηenry Dunant Hospital Center-4th Oncology Department and Clinical Trials Unit — Athens, Greece
Thoracic General Hospital Of Athens I Sotiria-3rd University Department of Internal Medicine — Athens, Greece
General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA — Athens, Greece
University General Hospital Attikon, 2nd Department of Propaedeutic and Internal Medicine — Athens, Greece
University General Hospital Of Larissa | Medical Oncology — Larissa, Greece
Metropolitan Hospital- 4th Oncology Clinic — Piraeus, Greece
Genesis Hospital- Department of Pathological Oncology — Pylaia Thessaloniki, Greece
Geniko Nosokomeio Thessalonikis George Papanikolaou-Pulmonary Department — Thessaloniki, Greece
Prince of Wales Hospital — Hong Kong, Hong Kong SAR, Hong Kong
Queen Elizabeth Hospital Hong Kong — Hong Kong, Hong Kong SAR, Hong Kong
Queen Mary Hospital — Hong Kong, Hong Kong SAR, Hong Kong
Hong Kong United Oncology Centre — Kowloon, Hong Kong
Komarom-Esztergom Varmegyei Szent Borbala Korhaz — Tatabánya, Komárom-Esztergom, Hungary
Budapesti Uzsoki Utcai Korhaz - Tüdőgyógyászati Osztály — Budapest, Hungary
Assuta Ashdod Public Hospital (R.A) — Ashdod, Central District, Israel
Soroka Medical Center- Legacy Heritage Cancer Center — Beersheba, Southern District, Israel
Shaare Zedek Medical Center (SZMC) — Jerusalem, Israel
Tel- Aviv Sourasky Medical Center - Nephrology — Tel Aviv, Israel
Ospedale Vito Fazzi Lecce - Oncologia — Lecce, Apulia, Italy
AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica — Avellino, Campania, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica — Bologna, Emilia-Romagna, Italy
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica — Meldola, Emilia-Romagna, Italy
Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati — Aviano, Friuli Venezia Giulia, Italy
I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2 — Rome, Lazio, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare — Rome, Lazio, Italy
Ospedale San Raffaele s.r.l. - Oncologia Medica — Milan, Lombardy, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1 — Milan, Lombardy, Italy
Istituto Europeo di Oncologia s.r.l - Oncologia Toracica — Milan, Lombardy, Italy
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia — Rozzano, Lombardy, Italy
ASST Sette Laghi_Ospedale Macchi - Oncologia — Varese, Lombardy, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica — Orbassano, Piedmont, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica — Palermo, Sicily, Italy
Careggi University Hospital - Oncologia Clinica — Florence, Tuscany, Italy
Istituto Oncologico Veneto_Padova - UOC Oncologia 2 — Padova, Veneto, Italy
Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia — Verona, Veneto, Italy
National Hospital Organization Nagoya Medical Center — Nagoya, Aichi-ken, Japan
National Cancer Center Hospital East — Kashiwa, Chiba, Japan
Hokkaido University Hospital — Sapporo, Hokkaido, Japan
National Hospital Organization Himeji Medical Center — Himeji, Hyōgo, Japan
Kobe University Hospital — Kobe, Hyōgo, Japan
Kitasato University Hospital — Sagamihara, Kanagawa, Japan
Sendai Kousei Hospital — Sendai, Miyagi, Japan
Kansai Medical University Hospital — Hirakata, Osaka, Japan
Kindai University Hospital — Sakai, Osaka, Japan
Saitama Cancer Center — Kitaadachi, Saitama, Japan
Nippon Medical School - Nippon Medical School Hospital - Cancer Center — Bunkyo-ku, Tokyo, Japan
Tottori University Hospital — Yonago, Tottori, Japan
National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital) — Ube, Yamaguchi, Japan
National Hospital Organization Kyushu Medical Center — Fukuoka, Japan
Niigata Cancer Center Hospital — Niigata, Japan
Osaka International Cancer Institute — Osaka, Japan
Universiti Malaya Medical Centre — Kuala Lumpur, Kuala Lumpur, Malaysia
University Hospital Kebangsaan Malaysia — Cheras, Kuala Lumpur and Selangor, Malaysia
Gleneagles Penang Medical Center — George Town, Pulau Pinang, Malaysia
Sunway Medical Centre Penang — Perai, Pulau Pinang, Malaysia
Beacon Hospital — Petaling Jaya, Selangor, Malaysia
Columbia Asia Hospital Bukit Rimau — Shah Alam, Selangor, Malaysia
Sunway Medical Centre — Subang Jaya, Selangor, Malaysia
Instituto Nacional de Cancerología — Mexico City, Mexico City, Mexico
Oncare Viaducto Nápoles — Mexico City, Mexico City, Mexico
Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia — Monterrey, Nuevo León, Mexico
ONCARE Treatment Center — San Pedro Garza García, Nuevo León, Mexico
Oncología Integral Satélite — Naucalpan, State of Mexico, Mexico
Clinica Integral Internacional de Oncologia S. de R.L. de C.V. — Puebla City, Mexico
Radboud University Medical Center | Afdeling Interne Geneeskunde — Nijmegen, Gelderland, Netherlands
Nederlands Kanker Instituut — Amsterdam, North Holland, Netherlands
Wielkopolskie Centrum Pulmonologii i Torakochirurgii — Poznan, Greater Poland Voivodeship, Poland
Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii — Wroclaw, Lower Silesian Voivodeship, Poland
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku — Otwock, Masovian Voivodeship, Poland
Instytut Gruzlicy i Chorob Pluc — Warsaw, Masovian Voivodeship, Poland
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej — Warsaw, Masovian Voivodeship, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku — Bialystok, Podlaskie Voivodeship, Poland
Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Łodzi — Lodz, Łódź Voivodeship, Poland
Swietokrzyskie Centrum Onkologii — Kielce, Świętokrzyskie Voivodeship, Poland
Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Oncologia — Coimbra, Beira Litoral, Portugal
Hospital Pedro Hispano | Clinical Research Center — Matosinhos Municipality, Porto District, Portugal
Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica — Lisbon, Portugal
CHULN - Hospital Pulido Valente — Lisbon, Portugal
IPO Porto — Porto, Portugal
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicală II — Bucharest, Bucharest Municipality, Romania
Spitalul Clinic Coltea — Bucharest, Bucharest Municipality, Romania
CardioMed S.R.L. — Cluj-Napoca, Cluj, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta — Cluj-Napoca, Cluj, Romania
Radiotherapy Center Cluj SRL — Florești, Comuna Floresti, Romania
S.C Ovidius Clinical Hospital SRL - Oncology Department — Ovidiu, Constanța County, Romania
Sc Oncolab Srl — Craiova, Dolj, Romania
Centrul de Oncologie Sfantul Nectarie — Craiova, Dolj, Romania
Oncocenter — Timișoara, Timiș County, Romania
National Cancer Center Singapore - Oncology Department — Singapore, Singapore
Raffles Cancer Centre — Singapore, Singapore
OncoCare Cancer Centre | Gleneagles Medical Centre — Singapore, Singapore
Tan Tock Seng Hospital — Singapore, Singapore
Curie Oncology | Farrer — Singapore, Singapore
POKO Poprad s.r.o. — Poprad, Presov, Slovakia
Fakultna nemocnica Trnava — Trnava, Slovakia
St Vincent's Hospital | Oncology — Suwon, Gyeonggi-do, South Korea
Gyeongsang National University Hospital | Oncology — Jinju, Gyeongsangnam-do, South Korea
Pusan National University Yangsan Hospital | Pulmonology — Yangsan, Gyeongsangnam-do, South Korea
Chonnam National University Hwasun Hospital | Pulmonology and Critical Care Medicine — Hwasun-gun, Jeollanam-do, South Korea
Chungbuk National University Hospital | Hematology and Oncology — Chungcheongbuk-do, North Chungcheong, South Korea
Seoul National University Hospital | Oncology — Jongno -Gu, Seoul, South Korea
Severance Hospital | Oncology — Seoul, South Korea
Samsung Medical Center | Oncology — Seoul, South Korea
Hospital Germans Trias I Pujol | Oncologia — Badalona, Barcelona, Spain
Hospital Universitario Puerta De Hierro De Majadahonda | Oncologia — Majadahonda, Madrid, Spain
Hospital Universitario De Navarra | Oncologia — Pamplona, Navarre, Spain
Complexo Hospitalario Universitario A Coruna | Oncologia — A Coruña, Spain
Hospital Universitari Dexeus Grupo Quironsalud | Oncologia — Barcelona, Spain
Hospital Universitari Vall D Hebron | Oncologia — Barcelona, Spain
Hospital Clinic De Barcelona | Oncologia — Barcelona, Spain
Hospital General Universitario Gregorio Maranon | Oncologia — Madrid, Spain
Hospital Universitario Ramon Y Cajal | Oncologia — Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz | Oncologia — Madrid, Spain
Fundacion Instituto Valenciano De Oncologia | Oncologia — Valencia, Spain
Hospital Universitario Y Politecnico La Fe | Oncologia — Valencia, Spain
Norrlands Universitetssjukhus Umeå - Cancercentrum — Umeå, Västerbotten County, Sweden
Skånes Universitetssjukhus - Lund - Lungmedicin — Lund, Sweden
Kantonsspital Baden — Baden, Canton of Aargau, Switzerland
HFR Freiburg - Kantonsspital — Fribourg, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
Chung Shan Medical University Hospital — Taichung, Taiwan
Taichung Veterans General Hospital — Taichung, Taiwan
National Cheng Kung University Hospital — Tainan, Taiwan
Chi-Mei Medical Center, Liouyine — Tainan, Taiwan
National Taiwan University Hospital (NTUH) - Cancer Research Center — Taipei, Taiwan
National Taiwan University Hospital — Taipei, Taiwan
Taipei Veterans General Hospital — Taipei, Taiwan
Adana Sehir Egitim ve Arastirma Hastanesi — Yüreğir, Adana, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi — Bilkent Ankara, Aksaray, Turkey (Türkiye)
Ankara Etlik Sehir Hastanesi — Yenimahalle, Ankara, Turkey (Türkiye)
İstanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçın Şehir Hastanesi — Kadıköy, Istanbul, Turkey (Türkiye)
İ.A.Ü. VM Medical Park Florya Hastanesi — Küçükçekmece, Istanbul, Turkey (Türkiye)
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi — Istanbul, Turkey (Türkiye)
Ege Universitesi Tip Fakultesi Hastanesi — Izmir, Turkey (Türkiye)
Sakarya Universitesi Egitim ve Arastirma Hastanesi — Sakarya, Turkey (Türkiye)
LLC "RDP Ukraine" - Medical Department — Dnipro, Dnipropetrovsk Oblast, Ukraine
Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center — Kropyvnytskyi, Kirovohrad Oblast, Ukraine
Kyiv City Clinical Oncology Center - Department of Chemotherapy #1 — Kyiv, Kyiv City, Ukraine
Limited Liability Company "MedOffice Group Medical Center" — Kyiv, Kyiv City, Ukraine
Medical Center LLC "Verum Expert Clinic" — Kyiv, Kyiv City, Ukraine
Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department — Rivne, Rivne Oblast, Ukraine
Regional Medical Oncology Centre_Oncology Chemotherapy Department — Lutsk, Volyn Oblast, Ukraine
MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department — Uzhhorod, Zakarpattia Oblast, Ukraine
Torbay Hospital | Oncology — Torquay, Devon, United Kingdom
Belfast City Hospital | Oncology — Belfast, Northern Ireland, United Kingdom
Royal Surrey County Hospital | Cancer Centre — Guildford, Surrey, United Kingdom
Velindre Cancer Centre | Clinical Trials Unit — Cardiff, Wales, United Kingdom

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