7T Amygdala and Citalopram Study
Sponsor: University of Oxford • ClinicalTrials.gov ID: NCT06412315
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The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds to emotional information. Healthy participants will undergo medical and psychiatric health screening, after which they will be assigned to receive either a single dose of citalopram (20mg) or placebo, and undergo brain scanning (7T fMRI) whilst viewing emotional faces. Since the scan uses high field strength, the investigators will be able to see effects of citalopram on different subfields within the amygdala which will help to understand how citalopram might be working.
Interventions
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Citalopram
(Drug)
Participants will receive a single dose (20mg) citalopram. Tablets encapsulated to aid blinding. To take per oral once.
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Placebo
(Drug)
Participants will receive a single dose of placebo (sucrose). Tablets encapsulated to aid blinding. To take per oral once
Eligibility criteria
Conditions
Locations
- University of Oxford, Department of Psychiatry — Oxford, Oxfordshire, United Kingdom
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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