RECRUITING Phase 2 ClinicalTrials.gov

Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)

Sponsor: Université du Québec à Trois-Rivières • ClinicalTrials.gov ID: NCT06401317

Registry updated: 2026-08-18

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Description

Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life. Although corticosteroids injections are a typical treatment, their effectiveness has been challenged, and side effects have been reported. Recent studies suggest that saline injections, usually considered inactive, might be a viable treatment option. The primary goal of this study is to compare the effectiveness of saline injections versus corticosteroids injections in reducing TMO-related pain and improving hand function. In this study, 40 people with TMO will be randomly assigned to receive either a corticosteroids or a saline injection, without them or the doctors performing the injection knowing which one was administered (double blind). If saline injections prove more effective, they could provide a less harmful and cheaper therapeutic alternative for TMO patients.

Interventions

Saline Solution (NaCl 0,9%) (Drug)
Ultrasound/fluoroscopy-guided intra-articular injection of 0.25ml of 0.9% saline solution.
Triamcinolone Acetonide (Drug)
Ultrasound-guided intra-articular injection 0.25ml (10 mg) of triamcinolone.

Eligibility criteria

Inclusion Criteria: * aged ≥18 years; * diagnosis of TMO was confirmed by X-ray interpreted by a radiologist; * suffering from pain at the base of the thumb; * the attending physician deems that an intra-articular corticosteroid injection would be beneficial, rather than opting for other types of intervention such as surgery * can read, understand and answer in either French or English. Exclusion Criteria: * having received one or more corticosteroid injections in the last 3 months or surgery on the affected thumb; * suffering from painful thumb caused by a trauma (e.g., fracture, sprain), rheumatoid arthritis, or De Quervain's tendonitis; and * being pregnant or breastfeeding; and * known allergies to any components of the solutions (triamcinolone acetonide, benzyl alcohol, carboxymethylcellulose sodium, hydrochloric acid, polysorbate, sodium chloride, or sodium hydroxide) or to iodinated contrast media.

Conditions

Trapeziometacarpal Osteoarthritis

Locations

Centre Hospitalier de l'Université de Montréal - Physiatry — Montreal, Quebec, Canada
Centre Hospitalier de l'Université de Montréal - Chirurgie plastique — Montreal, Quebec, Canada

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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