Safety and Efficacy of Ventricular Irrigation for Ventriculitis

Description

Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis. The mortality rate of ventriculitis is generally reported to be higher than 30%, with the highest reaching over 75%. Even among survivors, over 60% suffer from a variety of neurological sequelae, including cognitive impairment, gait disturbances, paralysis, behavioral disorders, and epilepsy. Currently, treatments for ventriculitis recommended by guidelines primarily focus on the selection and administration of antibiotics, while the effects of surgical interventions have not been fully elucidated. In recent years, several studies have explored the use of ventricular irrigation in ventriculitis, indicating that ventricular irrigation techniques may accelerate the control of ventricular infection, mitigate damage to the central nervous system caused by infections, improve the prognosis of ventriculitis, and reduce complications such as hydrocephalus. However, current studies are still relatively scarce, and mostly case reports and retrospective studies. High-quality evidence is still lacking for the application of ventricular irrigation in ventriculitis. This multicenter randomized controlled trial aims to explore the safety and effectiveness of ventricular irrigation compared to conventional treatment for ventriculitis, analyze the effectiveness of ventricular irrigation across different pathogen subgroups, and investigate independent risk factors for different prognostic states in patients with ventriculitis.

Interventions

• Ventricular irrigation (Procedure)
  Catheter ventricular irrigation can be employed by various forms. Lavage is performed with with each time at least 200ml of saline. Aside from lavage sessions, the lavage is paused, but continuous CSF drainage remains open.

Eligibility criteria

Conditions

Locations

• The First Affiliated Hospital of University of Science and Technology of China — Hefei, Anhui, China
• The Second People's Hospital of Anhui Province — Hefei, Anhui, China
• The First Affiliated Hospital of Wannan Medical College — Wuhu, Anhui, China
• Xuanwu Hospital Capital Medical University — Beijing, Beijing Municipality, China
• The First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China
• Nanfang Hospital, Southern Medical University — Guangzhou, Guangdong, China
• Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China
• Shenzhen Second People's Hospital — Shenzhen, Guangdong, China
• Zhongshan Hospital of Traditional Chinese Medicine — Zhongshan, Guangdong, China
• The First Affiliated Hospital of Harbin Medical University — Harbin, Heilongjiang, China
• Henan Provincial People's Hospital — Zhengzhou, Henan, China
• Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology — Wuhan, Hubei, China
• Xiangya Hospital of Central South University — Changsha, Hunan, China
• Jiangsu Province Hospital — Nanjing, Jiangsu, China
• Nanjing Drum Tower Hospital — Nanjing, Jiangsu, China
• Affiliated Hospital of Nantong University — Nantong, Jiangsu, China
• The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China
• 904 Hospital of the People's Liberation Army Joint Logistic Support Force — Wuxi, Jiangsu, China
• Affiliated Hospital of Yangzhou University — Yangzhou, Jiangsu, China
• Ganzhou People's Hospital — Ganzhou, Jiangxi, China
• The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
• The Fourth Affiliated Hospital of China Medical University — Shenyang, Liaoning, China
• The Second Affiliated Hospital of Air Force Medical University — Xi'an, Shaanxi, China
• Qilu Hospital of Shandong University — Jinan, Shandong, China
• Renji Hospital, School of Medicine, Shanghai Jiaotong University — Shanghai, Shanghai Municipality, China
• Shanghai Donglei Brain Hospital — Shanghai, Shanghai Municipality, China
• Shanghai East Hospital — Shanghai, Shanghai Municipality, China
• Shanghai Tenth People's Hospital — Shanghai, Shanghai Municipality, China
• The Second Affiliated Hospital of Naval Medical University — Shanghai, Shanghai Municipality, China
• West China Hospital, Sichuan University — Chengdu, Sichuan, China
• Inner Mongolia People's Hospital — Hohhot, The Nei Monggol Autonomous Region, China
• The First Affiliated Hospital of Xinjiang Medical University — Ürümqi, Xinjiang Uygur Autonomous Region, China
• First Affiliated Hospital of Zhejiang University — Hangzhou, Zhejiang, China
• South taihu hospital affiliated to huzhou college — Huzhou, Zhejiang, China
• The affiliated people's hospital of ningbo university — Ningbo, Zhejiang, China