RECRUITING Phase 3 ClinicalTrials.gov

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

Sponsor: Merck Sharp & Dohme LLC • ClinicalTrials.gov ID: NCT06312176

Registry updated: 2026-10-13

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Description

The purpose of this study is to compare sacituzumab tirumotecan as a single agent, and in combination with pembrolizumab, versus Treatment of Physician's Choice (TPC) in participants with hormone receptor positive/human epidermal growth factor receptor-2 negative (HR+/HER2-) unresectable locally advanced, or metastatic, breast cancer. The primary hypotheses are that sacituzumab tirumotecan as a single agent and sacituzumab tirumotecan plus pembrolizumab are superior to TPC with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent central review (BICR) in all participants.

Interventions

Sacituzumab tirumotecan (Drug)
IV infusion
Pembrolizumab (Biological)
IV infusion
Paclitaxel (Drug)
IV infusion
Nab-paclitaxel (Drug)
IV infusion
Capecitabine (Drug)
oral tablet
Liposomal doxorubicin (Drug)
IV infusion

Eligibility criteria

Inclusion Criteria: * Has unresectable locally advanced or metastatic centrally-confirmed hormone receptor positive (HR+)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer * Has radiographic disease progression on one or more lines of endocrine therapy for unresectable locally advanced/metastatic HR+/HER2- breast cancer, with one in combination with a CDK4/6 inhibitor * Is a chemotherapy candidate * Has an eastern cooperative oncology group (ECOG) performance status of 0 to 1 assessed within 7 days before randomization * Has adequate organ function * Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy * Participants who are Hepatitis B surface antigen (HBsAg) positive are eligible if they have received HBV antiviral therapy for at least 4 weeks, and have undetectable HBV viral load * Participants with a history of Hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable Exclusion Criteria: * Has breast cancer amenable to treatment with curative intent * Has experienced an early recurrence (\<6 months after completing adjuvant/neoadjuvant chemotherapy) and therefore is eligible to receive second-line (2L) treatment * Has symptomatic advanced/metastatic visceral spread at risk of rapidly evolving into life-threatening complications * Has received prior chemotherapy for unresectable locally advanced or metastatic breast cancer * Active autoimmune disease that has required systemic treatment in the past 2 years * History of (noninfectious) pneumonitis/interstitial lung disease that requires steroids, or has current pneumonitis/interstitial lung disease * Has an active infection requiring systemic therapy

Conditions

Breast Neoplasms

Locations

Ironwood Cancer & Research Centers ( Site 0066) — Chandler, Arizona, United States
Banner MD Anderson Cancer Center-Oncology ( Site 0004) — Gilbert, Arizona, United States
Providence Medical Foundation-Oncology ( Site 0020) — Fullerton, California, United States
Moores Cancer Center ( Site 0059) — La Jolla, California, United States
Cancer and Blood Specialty Clinic ( Site 0001) — Los Alamitos, California, United States
University of Colorado Anschutz Medical Campus ( Site 0061) — Aurora, Colorado, United States
UCHealth Cherry Creek Medical Center ( Site 0094) — Denver, Colorado, United States
University of Colorado Health - Highlands Ranch Hospital ( Site 0095) — Highlands Ranch, Colorado, United States
Yale Cancer Center ( Site 0060) — New Haven, Connecticut, United States
Stamford Hospital ( Site 0049) — Stamford, Connecticut, United States
AdventHealth Altamonte Springs ( Site 0021) — Altamonte Springs, Florida, United States
University of Florida College of Medicine ( Site 0063) — Gainesville, Florida, United States
Orlando Health Cancer Institute ( Site 0011) — Orlando, Florida, United States
Archbold Memorial Hospital-Lewis Hall Singletary Oncology Center ( Site 0032) — Thomasville, Georgia, United States
Rush University Medical Center ( Site 0079) — Chicago, Illinois, United States
University of Chicago Medical Center ( Site 0067) — Chicago, Illinois, United States
Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0053) — Edgewood, Kentucky, United States
Mary Bird Perkins Cancer Center-Breast & GYN Pavilion ( Site 0042) — Baton Rouge, Louisiana, United States
Greenebaum Comprehensive Cancer Center ( Site 0036) — Baltimore, Maryland, United States
Mercy Medical Center - Baltimore-Medical Oncology and Hematology ( Site 0028) — Baltimore, Maryland, United States
Holy Cross Hospital ( Site 0073) — Silver Spring, Maryland, United States
Dana-Farber Cancer Institute-Breast Oncology Center ( Site 0037) — Boston, Massachusetts, United States
Henry Ford Health ( Site 0002) — Detroit, Michigan, United States
Saint Luke's Cancer Institute ( Site 0027) — Kansas City, Missouri, United States
Washington University School of Medicine ( Site 0076) — St Louis, Missouri, United States
NYU Langone Health - Brooklyn ( Site 0089) — Brooklyn, New York, United States
NYU Langone Hospital - Long Island ( Site 0090) — Mineola, New York, United States
Laura and Isaac Perlmutter Cancer Center-Hematology and Oncology ( Site 0068) — New York, New York, United States
Hematology Oncology Associates of Rockland ( Site 0054) — Nyack, New York, United States
Stony Brook University-Cancer Center ( Site 0034) — Stony Brook, New York, United States
Levine Cancer Institute ( Site 0014) — Charlotte, North Carolina, United States
Zangmeister Cancer Center ( Site 7000) — Columbus, Ohio, United States
Providence Portland Medical Center ( Site 0044) — Portland, Oregon, United States
Providence St. Vincent Medical Center ( Site 0081) — Portland, Oregon, United States
Thomas Jefferson University - Clinical Research Institute ( Site 0056) — Philadelphia, Pennsylvania, United States
Texas Oncology-Dallas Presbyterian Hospital ( Site 8000) — Dallas, Texas, United States
Parkland Health and Hospital System ( Site 0069) — Dallas, Texas, United States
UT Southwestern Medical Center ( Site 0050) — Dallas, Texas, United States
The Center for Cancer and Blood Disorders ( Site 0041) — Fort Worth, Texas, United States
Texas Oncology - San Antonio ( Site 8002) — San Antonio, Texas, United States
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0057) — Tyler, Texas, United States
Inova Schar Cancer Institute ( Site 0025) — Fairfax, Virginia, United States
Bon Secours St. Francis Medical Center-Oncology Research ( Site 0015) — Midlothian, Virginia, United States
VCU Health Adult Outpatient Pavillion ( Site 0070) — Richmond, Virginia, United States
Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 8001) — Roanoke, Virginia, United States
University Hospital and UW Health Clinics-Carbone Cancer Center ( Site 0040) — Madison, Wisconsin, United States
Instituto Alexander Fleming-Alexander Fleming ( Site 0382) — Buenos Aires, Buenos Aires F.D., Argentina
Fundacion Estudios Clinicos-Oncology ( Site 0384) — Rosario, Santa Fe Province, Argentina
Hospital Aleman-Oncology ( Site 0386) — Buenos Aires, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0383) — Buenos Aires, Argentina
Hospital Italiano de Córdoba ( Site 0385) — Córdoba, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0387) — La Rioja, Argentina
Macquarie University-MQ Health Clinical Trials Unit ( Site 2002) — Macquarie University, New South Wales, Australia
Westmead Hospital ( Site 2000) — Westmead, New South Wales, Australia
Frankston Hospital-Oncology and Haematology ( Site 2003) — Frankston, Victoria, Australia
Fiona Stanley Hospital-Medical Oncology ( Site 2004) — Murdoch, Western Australia, Australia
Institut Jules Bordet-Medicine Oncology ( Site 1104) — Anderlecht, Bruxelles-Capitale, Region de, Belgium
Cliniques universitaires Saint-Luc-Medical Oncology ( Site 1103) — Brussels, Bruxelles-Capitale, Region de, Belgium
Jessa Ziekenhuis-Limburgs Oncologisch Centrum ( Site 1105) — Hasselt, Limburg, Belgium
AZ Maria Middelares-IKG ( Site 1106) — Ghent, Oost-Vlaanderen, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier -Oncology ( Site 1107) — Namur, Belgium
Oncoclínica Oncologistas Associados-Clinical Research ( Site 0407) — Teresina, Piauí, Brazil
Hospital Moinhos de Vento ( Site 0403) — Porto Alegre, Rio Grande do Sul, Brazil
Hospital do Câncer Mãe de Deus ( Site 0404) — Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Oncologia Saint Gallen ( Site 0412) — Santa Cruz do Sul, Rio Grande do Sul, Brazil
Instituto do Câncer Brasil - Unidade Taubaté ( Site 0408) — Taubaté, São Paulo, Brazil
IBCC - Núcleo de Pesquisa e Ensino ( Site 0401) — São Paulo, Brazil
BC Cancer Surrey ( Site 0315) — Surrey, British Columbia, Canada
Southlake Health ( Site 0311) — Newmarket, Ontario, Canada
Princess Margaret Cancer Centre ( Site 0310) — Toronto, Ontario, Canada
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0301) — Montreal, Quebec, Canada
Jewish General Hospital ( Site 0303) — Montreal, Quebec, Canada
CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0302) — Québec, Quebec, Canada
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0308) — Rimouski, Quebec, Canada
FALP-UIDO ( Site 0451) — Santiago, Region M. de Santiago, Chile
Oncovida ( Site 0453) — Santiago, Region M. de Santiago, Chile
Clínica RedSalud Vitacura ( Site 0455) — Santiago, Region M. de Santiago, Chile
Pontificia Universidad Catolica de Chile ( Site 0454) — Santiago, Region M. de Santiago, Chile
Bradfordhill ( Site 0452) — Santiago, Region M. de Santiago, Chile
Bradford Hill Norte ( Site 0456) — Antofagasta, Chile
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0506) — Medellín, Antioquia, Colombia
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0507) — Bogotá, Bogota D.C., Colombia
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0501) — Valledupar, Cesar Department, Colombia
IMAT S.A.S ( Site 0502) — Montería, Departamento de Córdoba, Colombia
Fundación Valle del Lili ( Site 0508) — Cali, Valle del Cauca Department, Colombia
CIMCA ( Site 0551) — San José, Provincia de San José, Costa Rica
Hospital Metropolitano - Sede Lindora ( Site 0550) — Santa Ana, Provincia de San José, Costa Rica
ICIMED ( Site 0552) — San José, Costa Rica
Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 1134) — Ostrava-Poruba, Moravian-Silesian Region, Czechia
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 1132) — Olomouc, Olomouc Region, Czechia
Nemocnice Ceske Budejovice-Onkologicke oddeleni ( Site 1138) — České Budějovice, South Bohemian Region, Czechia
Fakultni nemocnice Kralovske Vinohrady-Onkologická klinika ( Site 1135) — Prague, Czechia
Fakultní nemocnice Motol a Homolka ( Site 1136) — Prague, Czechia
Rigshospitalet ( Site 1180) — Copenhagen, Capital Region, Denmark
Nordsjællands Hospital - Hillerød ( Site 1184) — Hillerød, Capital Region, Denmark
Næstved Sygehus ( Site 1182) — Næstved, Region Sjælland, Denmark
Odense Universitetshospital ( Site 1181) — Odense C, Region Syddanmark, Denmark
Vejle Sygehus ( Site 1183) — Vejle, Region Syddanmark, Denmark
Hopital Prive Jean Mermoz-Oncology ( Site 1246) — Lyon, Auvergne-Rhône-Alpes, France
Centre François Baclesse ( Site 1250) — Caen, Calvados, France
Centre de Cancérologie du Grand Montpellier ( Site 1244) — Montpellier, Languedoc-Roussillon, France
Hôpital privé du Confluent SAS-Service d'oncologie médicale ( Site 1242) — Nantes, Loire-Atlantique, France
Centre Hospitalier Universitaire de Poitiers-Pôle régional de cancérologie ( Site 1243) — Poitiers, Vienne, France
Pitie Salpetriere University Hospital ( Site 1249) — Paris, France
Institut Curie-Oncology medical Department ( Site 1240) — Paris, France
Universitaetsklinikum Erlangen-Klinik für Gynäkologie und Geburtshilfe ( Site 1301) — Erlangen, Bavaria, Germany
Klinikum der Ludwig-Maximilians-Universitaet Muenchen-Frauenklinik Brustzentrum ( Site 1303) — München, Bavaria, Germany
Klinikum Ernst von Bergmann-Frauenklinik ( Site 1305) — Potsdam, Brandenburg, Germany
Franziskus-Hospital Harderberg ( Site 1308) — Georgsmarienhütte, Lower Saxony, Germany
Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1311) — Düsseldorf, North Rhine-Westphalia, Germany
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinike für Senologie/ Brustzentrum ( Site 1300) — Essen, North Rhine-Westphalia, Germany
CaritasKlinikum Saarbruecken St. Theresia ( Site 1304) — Saarbrücken, Saarland, Germany
SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1315) — Gera, Thuringia, Germany
Helios Klinikum Berlin-Buch-Klinik für Gynäkologie und Geburtshilfe ( Site 1314) — Berlin, Germany
Errikos Dunant Hospital Center ( Site 1348) — Athens, Attica, Greece
Aretaieio Hospital Oncology Unit ( Site 1345) — Athens, Attica, Greece
Hygeia Hospital ( Site 1346) — Marousi, Attica, Greece
University General Hospital of Larissa ( Site 1343) — Larissa, Thessaly, Greece
European Interbalkan Medical Center ( Site 1341) — Thessaloniki, Greece
European Interbalkan Medical Center ( Site 1347) — Thessaloniki, Greece
Queen Mary Hospital ( Site 2040) — Hksar, Hong Kong
Prince of Wales Hospital ( Site 2041) — Shatin, Hong Kong
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterápiás Klinika ( Site 1379) — Szeged, Csongrád megye, Hungary
Somogy Vármegyei Kaposi Mór Oktató Kórház-Oncology center ( Site 1371) — Kaposvár, Somogy County, Hungary
Zala Vármegyei Szent Rafael Kórház-Onkológiai osztály ( Site 1372) — Zalaegerszeg, Zala County, Hungary
Semmelweis Egyetem-Belgyógyászati és Onkológiai Klinika ( Site 1381) — Budapest, Hungary
Budapesti Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 1373) — Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1375) — Debrecen, Hungary
Tata Memorial Hospital-Medical Oncology ( Site 2053) — Mumbai, Maharashtra, India
Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute-Centre for cancer ( Site 2056) — Mumbai, Maharashtra, India
All India Institute of Medical Sciences ( Site 2051) — New Delhi, National Capital Territory of Delhi, India
Rajiv Gandhi Cancer Institute And Research Centre-Department of Clinical Research ( Site 2052) — New Delhi, National Capital Territory of Delhi, India
Bon Secours Cork Hospital ( Site 1422) — Cork, Ireland
St. Vincent's University Hospital-Medical Oncology Research Department ( Site 1420) — Dublin, Ireland
Mater Misericordiae University Hospital-Clinical Trials Research Unit ( Site 1423) — Dublin, Ireland
Rambam Health Care Campus-Oncology Division ( Site 1452) — Haifa, Israel
Hadassah Medical Center ( Site 1451) — Jerusalem, Israel
Rabin Medical Center ( Site 1453) — Petah Tikva, Israel
Sheba Medical Center ( Site 1450) — Ramat Gan, Israel
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1480) — Meldola, Forli-Cesena, Italy
CRO-IRCCS ( Site 1478) — Aviano, Friuli Venezia Giulia, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1472) — Milan, Lombardy, Italy
Istituto Europeo di Oncologia IRCCS-Divisione di Senologia Medica ( Site 1475) — Milan, Lombardy, Italy
Istituto Clinico Humanitas ( Site 1476) — Rozzano, Milano, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1474) — Bologna, Italy
Ospedale San Martino ( Site 1479) — Genova, Italy
Ospedale San Raffaele-Oncologia Medica ( Site 1471) — Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1477) — Roma, Italy
Nagoya City University Hospital ( Site 2474) — Nagoya, Aichi-ken, Japan
National Cancer Center Hospital East ( Site 2463) — Kashiwa, Chiba, Japan
Hokkaido University Hospital ( Site 2460) — Sapporo, Hokkaido, Japan
Tokai University Hospital ( Site 2473) — Isehara, Kanagawa, Japan
St. Marianna University Hospital ( Site 2465) — Kawasaki, Kanagawa, Japan
Kitasato University Hospital ( Site 2471) — Sagamihara, Kanagawa, Japan
Kanagawa Cancer Center ( Site 2472) — Yokohama, Kanagawa, Japan
Mie University Hospital ( Site 2483) — Tsu, Mie-ken, Japan
Tohoku University Hospital ( Site 2482) — Sendai, Miyagi, Japan
The University of Osaka Hospital ( Site 2476) — Suita, Osaka, Japan
Saitama Medical University International Medical Center ( Site 2462) — Hidaka, Saitama, Japan
Juntendo University Hospital ( Site 2468) — Bunkyo, Tokyo, Japan
Cancer Institute Hospital of JFCR ( Site 2464) — Koto, Tokyo, Japan
Showa Medical University Hospital ( Site 2466) — Shinagawa, Tokyo, Japan
Tokyo Medical University Hospital ( Site 2467) — Shinjuku, Tokyo, Japan
National Center for Global Health and Medicine ( Site 2469) — Shinjuku, Tokyo, Japan
Fukushima Medical University Hospital ( Site 2461) — Fukushima, Japan
Gifu University Hospital ( Site 2486) — Gifu, Japan
Hiroshima City Hiroshima Citizens Hospital ( Site 2478) — Hiroshima, Japan
Social medical corporation Hakuaikai Sagara Hospital ( Site 2481) — Kagoshima, Japan
Kumamoto University Hospital ( Site 2480) — Kumamoto, Japan
Kyoto University Hospital ( Site 2475) — Kyoto, Japan
Okayama University Hospital ( Site 2485) — Okayama, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2477) — Osaka, Japan
Hospital Sultan Ismail ( Site 2153) — Johor Bahru, Johor, Malaysia
Sarawak General Hospital ( Site 2154) — Kuching, Sarawak, Malaysia
Pantai Hospital Kuala Lumpur ( Site 2151) — Kuala Lumpur, Malaysia
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0592) — Guadalajara, Jalisco, Mexico
Grupo Médico ASSET-Clinical Research ( Site 0596) — Mexico City, Mexico City, Mexico
Health Pharma Professional Research S.A. de C.V: ( Site 0598) — Mexico City, Mexico City, Mexico
INCAN-TUMORES MAMARIOS ( Site 0597) — Mexico City, Mexico City, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0590) — Monterrey, Nuevo León, Mexico
CENTRO MEDICO ZAMBRANO HELLION-Centro de Cáncer de Mama ( Site 0595) — San Pedro Garza García, Nuevo León, Mexico
Ziekenhuis Rijnstate-Rijnstate Centrum Oncologisch Onderzoek ( Site 1524) — Arnhem, Gelderland, Netherlands
Maastricht UMC+-Medical Oncology ( Site 1522) — Maastricht, Limburg, Netherlands
Amphia Ziekenhuis, locatie Breda Molengracht-oncologie ( Site 1523) — Breda, North Brabant, Netherlands
Catharina Ziekenhuis ( Site 1526) — Eindhoven, North Brabant, Netherlands
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)-medical oncology ( Site 1520) — Amsterdam, North Holland, Netherlands
Isala, locatie Zwolle ( Site 1525) — Zwolle, Overijssel, Netherlands
Meander Medisch Centrum ( Site 1521) — Amersfoort, Utrecht, Netherlands
Auckland City Hospital ( Site 2031) — Auckland, New Zealand
Clinica Vallesur - AUNA ( Site 0652) — Arequipa, Ariqipa, Peru
Hospital Militar Central Luis Arias Schereiber ( Site 0651) — Jesús María, Lima, Peru
Oncosalud ( Site 0650) — Lima, Muni Metro de Lima, Peru
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0653) — Lima, Peru
Metro Davao Medical and Research Center ( Site 2202) — Davao City, Davao Del Sur, Philippines
ST. LUKE'S MEDICAL CENTER-Medicine ( Site 2200) — Quezon City, National Capital Region, Philippines
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1582) — Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1584) — Siedlce, Masovian Voivodeship, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii ( Site 1580) — Warsaw, Masovian Voivodeship, Poland
Mazowiecki Szpital Onkologiczny ( Site 1581) — Wieliszew, Masovian Voivodeship, Poland
Mrukmed-Mrukmed ( Site 1592) — Rzeszów, Podkarpackie Voivodeship, Poland
Bialostockie Centrum Onkologii ( Site 1585) — Bialystok, Podlaskie Voivodeship, Poland
Szpitale Pomorskie Sp. z o. o.-Oddział Onkologii Klinicznej ( Site 1593) — Gdynia, Pomeranian Voivodeship, Poland
Narodowy Instytut Onkologii - Oddzial w Gliwicach-Centrum Diagnostyki i Leczenia Chorob Piersi ( Site 1590) — Gliwice, Silesian Voivodeship, Poland
Szpital Wojewódzki w Koszalinie. ( Site 1583) — Poland, West Pomeranian Voivodeship, Poland
Zachodniopomorskie Centrum Onkologii ( Site 1588) — Szczecin, West Pomeranian Voivodeship, Poland
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 1595) — Kielce, Świętokrzyskie Voivodeship, Poland
Unidade Local de Saude Amadora/Sintra - Hospital Prof Dr Fernando Fonseca ( Site 1663) — Lisbon, Lisbon District, Portugal
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 1661) — Lisbon, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 1662) — Porto, Portugal
Puerto Rico Medical Research Center LLC ( Site 0675) — Hato Rey, Puerto Rico
UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 0677) — San Juan, Puerto Rico
Spitalul Clinic Filantropia ( Site 1703) — Bucharest, Bucharest, Romania
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 1702) — Florești, Cluj, Romania
Centrul Medical Neolife- Baneasa ( Site 1704) — Bucharest, Romania
Institutul Oncologic Cluj ( Site 1701) — Cluj-Napoca, Romania
National University Hospital ( Site 2250) — Singapore, Central Singapore, Singapore
Mount Alvernia ICON Cancer Center ( Site 2251) — Singapore, North East, Singapore
CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE ( Site 2905) — Port Elizabeth, Eastern Cape, South Africa
Wits Clinical Research ( Site 2903) — Johannesburg, Gauteng, South Africa
Curo Oncology ( Site 2908) — Pretoria, Gauteng, South Africa
Sandton Oncology Medical Group (Pty) Ltd ( Site 2911) — Sandton, Gauteng, South Africa
Cancercare Rondebosch Oncology-Clinical trials ( Site 2904) — Cape Town, Western Cape, South Africa
Seoul National University Hospital-Internal Medicine ( Site 2353) — Seoul, South Korea
Severance Hospital, Yonsei University Health System-Medical oncology ( Site 2350) — Seoul, South Korea
Asan Medical Center-Department of Oncology ( Site 2352) — Seoul, South Korea
Samsung Medical Center-Division of Hematology/Oncology ( Site 2351) — Seoul, South Korea
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1758) — Pozuelo de Alarcón, Madrid, Spain
Hospital Beata María Ana ( Site 1755) — Madrid, Madrid, Comunidad de, Spain
HOSPITAL CLINICO DE VALENCIA-Oncology ( Site 1752) — Valencia, Valenciana, Comunitat, Spain
Hospital Universitari Vall d'Hebron-Oncology ( Site 1750) — Barcelona, Spain
Hospital Universitario Reina Sofia-Oncologia Medica ( Site 1754) — Córdoba, Spain
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 1756) — Madrid, Spain
Hospital Universitario Virgen Macarena ( Site 1757) — Seville, Spain
Karolinska Universitetssjukhuset Solna ( Site 1801) — Stockholm, Stockholm County, Sweden
Akademiska sjukhuset ( Site 1802) — Uppsala, Uppsala County, Sweden
Södra Älvsborgs Sjukhus Borås ( Site 1803) — Borås, Västra Götaland County, Sweden
University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 1844) — Basel, Canton of Basel-City, Switzerland
Spital Thun ( Site 1840) — Thun, Canton of Bern, Switzerland
Brust-Zentrum ( Site 1841) — Zurich, Canton of Zurich, Switzerland
Changhua Christian Hospital ( Site 2410) — Changhua, Taiwan
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 2413) — Kaohsiung City, Taiwan
National Cheng Kung University Hospital-Surgery ( Site 2411) — Tainan, Taiwan
National Taiwan University Hospital-Oncology ( Site 2415) — Taipei, Taiwan
Mackay Memorial Hospital ( Site 2412) — Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch-General Surgery ( Site 2414) — Taoyuan, Taiwan
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 1878) — Yenimahalle, Ankara, Turkey (Türkiye)
Medipol Mega Universite Hastanesi-oncology ( Site 1875) — Stanbul, Istanbul, Turkey (Türkiye)
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 1876) — Adana, Turkey (Türkiye)
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1870) — Ankara, Turkey (Türkiye)
Memorial Ankara Hastanesi-Medical Oncology ( Site 1874) — Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1871) — Ankara, Turkey (Türkiye)
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1872) — Istanbul, Turkey (Türkiye)
Samsun Medical Park Hastanesi-medical oncology ( Site 1873) — Samsun, Turkey (Türkiye)
North West Cancer Centre ( Site 1944) — Londonderry, Derry and Strabane, United Kingdom
The Royal Cornwall Hospital ( Site 1943) — Truro, England, United Kingdom
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1940) — London, London, City of, United Kingdom
University College London Hospital-Cancer Clinical Trials Unit ( Site 1942) — London, London, City of, United Kingdom
Blackpool Victoria Hospital ( Site 1941) — Blackpool, United Kingdom
City Hospital, Nottingham University Hospitals NHS Trust ( Site 1945) — Nottingham, United Kingdom

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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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