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Ex Vivo Tumor Visualization and Resection Margin Assessment Using Topically Applied Fluorescent Imaging Agents

Sponsor: Erasmus Medical Center • ClinicalTrials.gov ID: NCT06292845

Registry updated: 2026-09-11

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Description

This is a proof-of-principle study, that uses freshly resected human solid tumor specimens to assess the performance of topically applied fluorescent imaging agents for the detection of tumor tissue and close / tumor-positive resection margins ex vivo. Surgery will be performed in conformity with hospital protocol. The study will not interfere with the standard clinical care.

Interventions

Topical application of a fluorescent imaging agent (Drug)
The fluorescent imaging agent will be topically applied only onto the resection planes of the freshly resected tumor specimen. During incubation and after each washing steps, visible light and fluorescent overlay images will be acquired using a fluorescence sensitive camera system.

Eligibility criteria

Inclusion Criteria: 1. Patients with a biopsy-proven solid tumor, scheduled for surgery at the Erasmus Medical Center. 2. Signed and dated informed consent obtained before any study-related procedure is performed. Exclusion Criteria: 1. Terminated surgical procedure. 2. No fresh specimen available. 3. Participation in a clinical trial for which the patient receives another fluorophore perioperatively.

Conditions

Solid Tumor, Adult

Locations

Erasmus University Medical Center — Rotterdam, South Holland, Netherlands

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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