RECRUITING Not applicable ClinicalTrials.gov

Optimization of Radiation Protection Through Genomic Analyses

Sponsor: University Hospital, Essen • ClinicalTrials.gov ID: NCT06253338

Registry updated: 2026-10-20

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Description

The long-term goal is to define "signatures" in the form of genomic changes through sequence analyses of genomic DNA using modern Next Generation Sequencing (NGS) methods, which 1. determine the radiation exposure of humans. 2. provide information about the exposure (dose). 3. determine the radiation quality. 4. predict the repair capacity and radiation resistance of an individual.

Interventions

genomic alterations (Radiation)
Alteration of the genome under radiotherapy

Eligibility criteria

Inclusion Criteria: ECOG 0/1 no prior treatment no prior cancer diagnosis thoracic or head and neck cancer Exclusion Criteria: prior treatment (chemotherapy, radiotherapy, etc.) prior cancer diagnosis

Conditions

DNA Cancer Radiation

Locations

Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West — Essen, Germany / NRW, Germany

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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