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RECRUITING Not applicable ClinicalTrials.gov

Brain Stimulation Enhance Post-stroke Walking Survivors and Healthy Adults

Sponsor: The University of Texas Medical Branch, Galveston • ClinicalTrials.gov ID: NCT06191549

Registry updated: 2026-10-14
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Description

Recent studies showed that a non-invasive, low-intensity brain stimulation called transcranial direct current stimulation (tDCS) can effectively increase motor neuron excitability in the brain and therefore promotes functional recovery after stroke. Thus, the overall purpose of this research project is to examine the effect of brain stimulation on motor skill learning in stroke survivors.

Interventions

  • anodal transcranial direct current stimulation (a-tDCS) (Combination product)
    Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Young and older healthy adults will be randomly assignments into a-tDCS or s-tDCS groups. Stroke participants in each group will receive a four-week of the assigned brain stimulation combined with visuomotor stepping training and treadmill training

Eligibility criteria

Inclusion Criteria: * Age between 21 and 90 years * Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment * MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract * Hemiparesis involving the lower extremity (Fugl-Meyer Lower Extremity Motor Test) * No passive range of motion limitation in bilateral hips and knees * Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less * Visual acuity can be corrected by glasses or contact lens to 20/20 * Able to walk independently with/without assistant devices for 10 meters * Able to maintain standing position without any assistance \>= 30 sec (Short Physical Performance Battery) * Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24 Exclusion Criteria: * Pregnant women * MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or tumors * Have any metal implants, cardiac pacemakers, or history of seizures * Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training * Any vestibular dysfunction or unstable angina * Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia

Conditions

Cerebral Vascular Accident

Locations

  • University of Texas Medical Branch — Galveston, Texas, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record