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RECRUITING Not applicable ClinicalTrials.gov

rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCT

Sponsor: The University of Hong Kong • ClinicalTrials.gov ID: NCT06128746

Registry updated: 2026-09-28
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Description

This RCT aims to investigate the effect of repetitive transcranial magnatic stimulation (rTMS) in treating children with hemiplegoc cerebral palsy. The study will measure any improvement in spasticity after using contra-lesional inhibitory rTMS follow by intensive limb training. Participants will attend a 10-day rTMS treatment sessions, follow by intensive training of the impaired limb. They will also undergo MRI scans before and after the treatment to investiagte the underlying neurophysiological mechanisms that lead to changes clinically by using TMS as well as MR-DKI. Researchers will compare the intervention group and the sham group to see if rTMS could result in improvement of participants' spasticity.

Interventions

  • Repetitive Transcranial Magnetic Stimulation (Device)
    1 Hz rTMS treatment for 20 mins, followed by 1.5 hours of motor training.
  • Sham Repetitive Transcranial Magnetic Stimulation (Device)
    Sham Hz rTMS treatment for 20 mins, followed by 1.5 hours of motor training.

Eligibility criteria

Inclusion Criteria: * Patients aged between 4 years and 18 years * Diagnosis of hemiplegia * Upper limb spasticity ≥ 1 * IQ ≥ 50 Exclusion Criteria: * Any contra-indications to rTMS * Severe spasticity (score of 4 or more in Ashworth scale) * Uncontrollable epilepsy * History of Botulinum toxin A injection in previous 6 months * Upper limb casting in previous 6 months

Conditions

CP (Cerebral Palsy)

Locations

  • Li Ka Shing Faculty of Medicine — Hong Kong, Hong Kong, Hong Kong
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record