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RECRUITING Not applicable ClinicalTrials.gov

Cerebellar Involvement in Cognitive Sequencing

Sponsor: Johns Hopkins University • ClinicalTrials.gov ID: NCT06108336

Registry updated: 2026-09-14
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Description

Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.

Interventions

  • TMS during sequence-demanding task (Procedure)
    TMS is administered during the execution of sequence-demanding task. Transcranial magnetic stimulation (TMS) is a safe and non-invasive technique for transiently modulating brain activity
  • No TMS during sequence-demanding task (Procedure)
    TMS is not administered during the execution of sequence-demanding task.
  • TMS during non-sequence-demanding task (Procedure)
    TMS is administered during the execution of non-sequence-demanding task. Transcranial magnetic stimulation (TMS) is a safe and non-invasive technique for transiently modulating brain activity
  • No TMS during non-sequence-demanding task (Procedure)
    TMS is not administered during the execution of non-sequence-demanding task

Eligibility criteria

Inclusion Criteria: * 1\) Age 18-50; * 2\) educational attainment of at least 8 years; * 3\) capable of giving informed consent; * 4\) fluent speaker of English by self-report; * 5\) right handed. Exclusion Criteria: * 1\) illicit drug use within 30 days of MRI scanning; * 2\) neurological or systemic disorder which can cause dementia or cognitive dysfunction; * 3\) history of an Axis I psychiatric disorder including substance use disorder; * 4\) history of definite stroke; * 5\) focal lesion on MRI exam; * 6\) uncorrected visual deficits by self-report * 7\) contraindications for MRI scanning * 8\) use of anxiolytic, antidepressant, neuroleptic, or sedative medication * 9\) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease

Conditions

Effects of Cerebellar Stimulation on Brain Activation

Locations

  • Johns Hopkins University School of Medicine — Baltimore, Maryland, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record