RECRUITING Phase 3 ClinicalTrials.gov

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Sponsor: National Cancer Institute (NCI) • ClinicalTrials.gov ID: NCT06096844

Registry updated: 2026-10-08

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Description

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer.

Interventions

Carboplatin (Drug)
Given IV
Computed Tomography (Procedure)
Undergo CT scan
Magnetic Resonance Imaging (Procedure)
Undergo MRI
Nab-paclitaxel (Drug)
Given IV
Paclitaxel (Drug)
Given IV
Pembrolizumab (Biological)
Given IV
Pemetrexed (Drug)
Given IV
Positron Emission Tomography (Procedure)
Undergo PET
Questionnaire Administration (Other)
Ancillary studies

Eligibility criteria

Inclusion Criteria: * STEP 1 REGISTRATION * Patient must be ≥ 70 years of age * Patient must have histologically or cytologically confirmed non-small cell lung cancer (NSCLC) with PD-L1 Tumor Proportion Score (TPS) range of 1-49% * Patient must have Stage IIIB, IIIC or IV disease and not be candidates for combined chemo-radiation. NOTE: Prior chemo-radiation therapy (RT) for stage III with recurrence is allowed * Patient must have a tumor that is negative for EGFR mutation/ALK translocations or other actionable first line mutations in which patients would receive first-line oral tyrosine kinase inhibitors * Patient must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2 * Patient must agree not to father children while on study and for 6 months after the last dose of protocol treatment * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Absolute neutrophil count (ANC) ≥ 1,500/uL (obtained within 14 days prior to Step 1 registration) * Platelets ≥ 75,000/uL (obtained within 14 days prior to Step 1 registration) * Hemoglobin (Hgb) ≥ 8.0 g/dL (obtained within 14 days prior to Step 1 registration) * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (obtained within 14 days prior to Step 1 registration) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) ≤ 3.0 × institutional ULN (obtained within 14 days prior to Step 1 registration) * Creatinine clearance (CrCL) ≥ 45 mL/min (estimated using Cockcroft-Gault method with actual body weight or measured) (obtained within 14 days prior to Step 1 registration) * Human immunodeficiency virus (HIV)-infected patients on effective antiretroviral therapy with undetectable viral load within 6 months of Step 1 registration are eligible for this trial * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have undetectable HCV viral * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Patient must be English or Spanish speaking to be eligible for the QOL component of the study * NOTE: Sites cannot translate the associated GA or QOL forms * Patient must not have symptomatic central nervous system disease (CNS) metastases. Patients with a clinical history of CNS metastases or cord compression are eligible if they have been definitively treated and are clinically stable for at least 14 days prior to Step 1 registration and off all steroids for at least 24 hours prior to Step 1 registration. Patients with asymptomatic CNS metastases are eligible * Patient must not have had any prior cytotoxic chemotherapy regimen for metastatic disease. Chemotherapy given in the setting of adjuvant therapy or locally advanced disease is allowed as long as treatment was completed, and they have fully recovered from treatment related adverse events prior to Step 1 registration * Patient must not have had any prior immunotherapy for metastatic disease. Immunotherapy given in the setting of adjuvant therapy or locally advanced disease is allowed as long as treatment was completed greater than 6 months prior to Step 1 registration * Patient must not have a history of uncontrolled autoimmune conditions with the following exceptions, which are allowed: alopecia, vitiligo, rheumatoid arthritis, psoriasis/psoriatic arthritis, Hashimoto's thyroiditis, lupus, inflammatory bowel disease * Patient must not be on immunosuppressive medication, including steroids (if doses exceed the equivalent of prednisone 10 mg daily). Short courses of steroids which are discontinued prior to randomization are acceptable. Patients on inhaled, intranasal and/or topical steroids are eligible * Patient must have baseline imaging done assessing all measurable or non-measurable sites of disease within 45 days prior to Step 1 registration * Investigator must declare their intended chemotherapy regimen should their patient be randomized to Arm B (doublet versus\[vs\] singlet) * STEP 2 RANDOMIZATION * Patient must have completed the baseline Geriatric Assessment (GA) after Step 1 registration and prior to Step 2 randomization

Conditions

Advanced Lung Non-Small Cell Carcinoma Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8

Locations

Highlands Oncology Group - Fayetteville — Fayetteville, Arkansas, United States
Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
Highlands Oncology Group - Rogers — Rogers, Arkansas, United States
Highlands Oncology Group — Springdale, Arkansas, United States
Kaiser Permanente Dublin — Dublin, California, United States
Kaiser Permanente-Fremont — Fremont, California, United States
Kaiser Permanente Fresno Orchard Plaza — Fresno, California, United States
Kaiser Permanente-Fresno — Fresno, California, United States
Kaiser Permanente- Modesto MOB II — Modesto, California, United States
Kaiser Permanente-Modesto — Modesto, California, United States
Kaiser Permanente-Oakland — Oakland, California, United States
VA Palo Alto Health Care System — Palo Alto, California, United States
Kaiser Permanente-Roseville — Roseville, California, United States
Kaiser Permanente Downtown Commons — Sacramento, California, United States
Kaiser Permanente-South Sacramento — Sacramento, California, United States
Kaiser Permanente-San Francisco — San Francisco, California, United States
Kaiser Permanente-Santa Teresa-San Jose — San Jose, California, United States
Kaiser Permanente San Leandro — San Leandro, California, United States
Kaiser San Rafael-Gallinas — San Rafael, California, United States
Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
Kaiser Permanente-Santa Rosa — Santa Rosa, California, United States
Kaiser Permanente-South San Francisco — South San Francisco, California, United States
Kaiser Permanente-Vallejo — Vallejo, California, United States
Kaiser Permanente-Walnut Creek — Walnut Creek, California, United States
Stamford Hospital/Bennett Cancer Center — Stamford, Connecticut, United States
Veterans Affairs Connecticut Healthcare System-West Haven Campus — West Haven, Connecticut, United States
George Washington University Medical Center — Washington D.C., District of Columbia, United States
UM Sylvester Comprehensive Cancer Center at Aventura — Aventura, Florida, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida, United States
Holy Cross Hospital — Fort Lauderdale, Florida, United States
Malcom Randall Veterans Administration Medical Center — Gainesville, Florida, United States
UF Health Cancer Institute - Gainesville — Gainesville, Florida, United States
The Watson Clinic — Lakeland, Florida, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida, United States
UM Sylvester Comprehensive Cancer Center at Kendall — Miami, Florida, United States
Sacred Heart Hospital — Pensacola, Florida, United States
UM Sylvester Comprehensive Cancer Center at Plantation — Plantation, Florida, United States
Moffitt Cancer Center-International Plaza — Tampa, Florida, United States
James A. Haley Veterans Affairs Hospital — Tampa, Florida, United States
Moffitt Cancer Center - McKinley Campus — Tampa, Florida, United States
Moffitt Cancer Center — Tampa, Florida, United States
Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida, United States
CTCA at Southeastern Regional Medical Center — Newnan, Georgia, United States
Kaiser Permanente Moanalua Medical Center — Honolulu, Hawaii, United States
Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
Kootenai Clinic Cancer Services - Sandpoint — Sandpoint, Idaho, United States
Rush-Copley Medical Center — Aurora, Illinois, United States
Advocate Outpatient Center - Aurora — Aurora, Illinois, United States
Advocate Good Shepherd Hospital — Barrington, Illinois, United States
SIH Cancer Institute — Carterville, Illinois, United States
Rush MD Anderson Cancer Center — Chicago, Illinois, United States
University of Illinois — Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center — Chicago, Illinois, United States
AMG Crystal Lake - Oncology — Crystal Lake, Illinois, United States
Carle at The Riverfront — Danville, Illinois, United States
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
Decatur Memorial Hospital — Decatur, Illinois, United States
Advocate Good Samaritan Hospital — Downers Grove, Illinois, United States
Carle Physician Group-Effingham — Effingham, Illinois, United States
Crossroads Cancer Center — Effingham, Illinois, United States
Advocate Sherman Hospital — Elgin, Illinois, United States
Advocate South Suburban Hospital — Hazel Crest, Illinois, United States
AMG Libertyville - Oncology — Libertyville, Illinois, United States
Condell Memorial Hospital — Libertyville, Illinois, United States
Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
Loyola University Medical Center — Maywood, Illinois, United States
SSM Health Good Samaritan — Mount Vernon, Illinois, United States
Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
Advocate Christ Medical Center — Oak Lawn, Illinois, United States
Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
UW Health Carbone Cancer Center Rockford — Rockford, Illinois, United States
Memorial Hospital East — Shiloh, Illinois, United States
Southern Illinois University School of Medicine — Springfield, Illinois, United States
Springfield Clinic — Springfield, Illinois, United States
Springfield Memorial Hospital — Springfield, Illinois, United States
Carle Cancer Center — Urbana, Illinois, United States
Northwest Cancer Center - Crown Point — Crown Point, Indiana, United States
Northwest Oncology LLC — Dyer, Indiana, United States
Northwest Cancer Center - Hobart — Hobart, Indiana, United States
Saint Mary Medical Center — Hobart, Indiana, United States
Saint Catherine Hospital — Indianapolis, Indiana, United States
The Community Hospital — Munster, Indiana, United States
Women's Diagnostic Center - Munster — Munster, Indiana, United States
Northwest Cancer Center - Valparaiso — Valparaiso, Indiana, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic — Ankeny, Iowa, United States
Mercy Hospital — Cedar Rapids, Iowa, United States
Oncology Associates at Mercy Medical Center — Cedar Rapids, Iowa, United States
Mercy Cancer Center-West Lakes — Clive, Iowa, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic — Clive, Iowa, United States
Iowa Methodist Medical Center — Des Moines, Iowa, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic — Des Moines, Iowa, United States
Mercy Medical Center - Des Moines — Des Moines, Iowa, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic — Des Moines, Iowa, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic — Waukee, Iowa, United States
University of Kansas Clinical Research Center — Fairway, Kansas, United States
HaysMed — Hays, Kansas, United States
University of Kansas Cancer Center — Kansas City, Kansas, United States
Lawrence Memorial Hospital — Lawrence, Kansas, United States
Veteran Administration Eastern Kansas Healthcare — Leavenworth, Kansas, United States
The University of Kansas Cancer Center - Olathe — Olathe, Kansas, United States
University of Kansas Cancer Center-Overland Park — Overland Park, Kansas, United States
University of Kansas Hospital-Indian Creek Campus — Overland Park, Kansas, United States
Salina Regional Health Center — Salina, Kansas, United States
University of Kansas Health System Saint Francis Campus — Topeka, Kansas, United States
University of Kansas Hospital-Westwood Cancer Center — Westwood, Kansas, United States
University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
The James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky, United States
UofL Health Medical Center Northeast — Louisville, Kentucky, United States
Lafayette Family Cancer Center-EMMC — Brewer, Maine, United States
University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland, United States
Sinai Hospital of Baltimore — Baltimore, Maryland, United States
William E Kahlert Regional Cancer Center/Sinai Hospital — Westminster, Maryland, United States
Tufts Medical Center — Boston, Massachusetts, United States
Dana-Farber Cancer Institute at Boston Medical Center - Brighton — Brighton, Massachusetts, United States
Dana-Farber Cancer Institute at Foxborough — Foxborough, Massachusetts, United States
Dana Farber-Merrimack Valley — Methuen, Massachusetts, United States
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional — Milford, Massachusetts, United States
Dana-Farber/Brigham and Women's Cancer Center at South Shore — South Weymouth, Massachusetts, United States
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts, United States
Bronson Battle Creek — Battle Creek, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton — Canton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital — Chelsea, Michigan, United States
Cancer Hematology Centers - Flint — Flint, Michigan, United States
Genesee Hematology Oncology PC — Flint, Michigan, United States
Genesys Hurley Cancer Institute — Flint, Michigan, United States
Hurley Medical Center — Flint, Michigan, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital — Grand Rapids, Michigan, United States
Trinity Health Grand Rapids Hospital — Grand Rapids, Michigan, United States
Bronson Methodist Hospital — Kalamazoo, Michigan, United States
West Michigan Cancer Center — Kalamazoo, Michigan, United States
University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
Trinity Health Muskegon Hospital — Muskegon, Michigan, United States
Corewell Health Lakeland Hospitals - Niles Hospital — Niles, Michigan, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores — Norton Shores, Michigan, United States
Michigan Healthcare Professionals Pontiac — Pontiac, Michigan, United States
Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
Corewell Health Reed City Hospital — Reed City, Michigan, United States
MyMichigan Medical Center Saginaw — Saginaw, Michigan, United States
Oncology Hematology Associates of Saginaw Valley PC — Saginaw, Michigan, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center — Saint Joseph, Michigan, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital — Saint Joseph, Michigan, United States
MyMichigan Medical Center Tawas — Tawas City, Michigan, United States
Munson Medical Center — Traverse City, Michigan, United States
Saint Mary's Oncology/Hematology Associates of West Branch — West Branch, Michigan, United States
University of Michigan Health - West — Wyoming, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan, United States
Sanford Joe Lueken Cancer Center — Bemidji, Minnesota, United States
Minnesota Oncology - Burnsville — Burnsville, Minnesota, United States
Mercy Hospital — Coon Rapids, Minnesota, United States
Essentia Health - Deer River Clinic — Deer River, Minnesota, United States
Essentia Health Cancer Center — Duluth, Minnesota, United States
Fairview Southdale Hospital — Edina, Minnesota, United States
Essentia Health Hibbing Clinic — Hibbing, Minnesota, United States
Mayo Clinic Health Systems-Mankato — Mankato, Minnesota, United States
Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
Abbott-Northwestern Hospital — Minneapolis, Minnesota, United States
New Ulm Medical Center — New Ulm, Minnesota, United States
North Memorial Medical Health Center — Robbinsdale, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
Regions Hospital — Saint Paul, Minnesota, United States
United Hospital — Saint Paul, Minnesota, United States
Essentia Health Sandstone — Sandstone, Minnesota, United States
Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
Essentia Health Virginia Clinic — Virginia, Minnesota, United States
Saint Francis Medical Center — Cape Girardeau, Missouri, United States
Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
University Health Truman Medical Center — Kansas City, Missouri, United States
University of Kansas Cancer Center - Briarcliff — Kansas City, Missouri, United States
Kansas City Veterans Affairs Medical Center — Kansas City, Missouri, United States
University of Kansas Cancer Center - North — Kansas City, Missouri, United States
University of Kansas Cancer Center - Lee's Summit — Lee's Summit, Missouri, United States
Lake Regional Hospital — Osage Beach, Missouri, United States
Washington University School of Medicine — St Louis, Missouri, United States
Mercy Hospital South — St Louis, Missouri, United States
Siteman Cancer Center-South County — St Louis, Missouri, United States
Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
Mercy Hospital Saint Louis — St Louis, Missouri, United States
Community Hospital of Anaconda — Anaconda, Montana, United States
Billings Clinic Cancer Center — Billings, Montana, United States
Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
Benefis Sletten Cancer Institute — Great Falls, Montana, United States
Logan Health Medical Center — Kalispell, Montana, United States
Community Medical Center — Missoula, Montana, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center — Lebanon, New Hampshire, United States
The Dana-Farber Cancer Institute at Londonderry — Londonderry, New Hampshire, United States
Jefferson Cherry Hill Hospital — Cherry Hill, New Jersey, United States
Inspira Medical Center Mullica Hill — Mullica Hill, New Jersey, United States
Penn Medicine Princeton Health — Plainsboro, New Jersey, United States
Sidney Kimmel Cancer Center Washington Township — Sewell, New Jersey, United States
Glens Falls Hospital — Glens Falls, New York, United States
Upstate Cancer Center at Oswego — Oswego, New York, United States
University of Rochester — Rochester, New York, United States
Stony Brook University Medical Center — Stony Brook, New York, United States
State University of New York Upstate Medical University — Syracuse, New York, United States
SUNY Upstate Medical Center-Community Campus — Syracuse, New York, United States
Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
Montefiore Medical Center - Moses Campus — The Bronx, New York, United States
Upstate Cancer Center at Verona — Verona, New York, United States
Wilmot Cancer Institute at Webster — Webster, New York, United States
Southeastern Medical Oncology Center-Clinton — Clinton, North Carolina, United States
Durham VA Medical Center — Durham, North Carolina, United States
Southeastern Medical Oncology Center-Goldsboro — Goldsboro, North Carolina, United States
Southeastern Medical Oncology Center-Jacksonville — Jacksonville, North Carolina, United States
Sanford Bismarck Medical Center — Bismarck, North Dakota, United States
Sanford Broadway Medical Center — Fargo, North Dakota, United States
Sanford Roger Maris Cancer Center — Fargo, North Dakota, United States
UH Seidman Cancer Center at UH Avon Health Center — Avon, Ohio, United States
UHHS-Chagrin Highlands Medical Center — Beachwood, Ohio, United States
Strecker Cancer Center-Belpre — Belpre, Ohio, United States
Aultman Health Foundation — Canton, Ohio, United States
Miami Valley Hospital South — Centerville, Ohio, United States
Adena Regional Medical Center — Chillicothe, Ohio, United States
Case Western Reserve University — Cleveland, Ohio, United States
MetroHealth Medical Center — Cleveland, Ohio, United States
Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
The Mark H Zangmeister Center — Columbus, Ohio, United States
Miami Valley Hospital — Dayton, Ohio, United States
Premier Blood and Cancer Center — Dayton, Ohio, United States
Miami Valley Hospital North — Dayton, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
Miami Valley Cancer Care and Infusion — Greenville, Ohio, United States
Mount Carmel Grove City Hospital — Grove City, Ohio, United States
Memorial Hospital — Marysville, Ohio, United States
UH Seidman Cancer Center at Lake Health Mentor Campus — Mentor, Ohio, United States
Knox Community Hospital — Mount Vernon, Ohio, United States
Licking Memorial Hospital — Newark, Ohio, United States
Mercy Health - Perrysburg Hospital — Perrysburg, Ohio, United States
Springfield Regional Cancer Center — Springfield, Ohio, United States
Mercy Health - Saint Anne Hospital — Toledo, Ohio, United States
Upper Valley Medical Center — Troy, Ohio, United States
Genesis Healthcare System Cancer Care Center — Zanesville, Ohio, United States
Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma, United States
Saint Alphonsus Cancer Care Center-Ontario — Ontario, Oregon, United States
Bryn Mawr Hospital — Bryn Mawr, Pennsylvania, United States
Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania, United States
Lancaster General Ann B Barshinger Cancer Institute — Lancaster, Pennsylvania, United States
Riddle Memorial Hospital — Media, Pennsylvania, United States
Paoli Memorial Hospital — Paoli, Pennsylvania, United States
ECOG-ACRIN Cancer Research Group — Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
Jefferson Torresdale Hospital — Philadelphia, Pennsylvania, United States
Reading Hospital McGlinn Cancer Institute at Phoenixville — Phoenixville, Pennsylvania, United States
Guthrie Medical Group PC-Robert Packer Hospital — Sayre, Pennsylvania, United States
Reading Hospital — West Reading, Pennsylvania, United States
Asplundh Cancer Pavilion — Willow Grove, Pennsylvania, United States
Lankenau Medical Center — Wynnewood, Pennsylvania, United States
Ralph H Johnson VA Medical Center — Charleston, South Carolina, United States
Medical University of South Carolina — Charleston, South Carolina, United States
Rapid City Regional Hospital — Rapid City, South Dakota, United States
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota, United States
Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota, United States
Parkland Memorial Hospital — Dallas, Texas, United States
UT Southwestern Simmons Cancer Center - RedBird — Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas, United States
UT Southwestern Clinical Center at Richardson/Plano — Richardson, Texas, United States
Dartmouth Cancer Center - North — Saint Johnsbury, Vermont, United States
White River Junction Veteran Administration Medical Center — White River Junction, Vermont, United States
University of Virginia Cancer Center — Charlottesville, Virginia, United States
VCU Massey Cancer Center at Stony Point — Richmond, Virginia, United States
VCU Massey Comprehensive Cancer Center — Richmond, Virginia, United States
VCU Community Memorial Health Center — South Hill, Virginia, United States
VCU Health Tappahannock Hospital — Tappahannock, Virginia, United States
Swedish Cancer Institute-Edmonds — Edmonds, Washington, United States
Swedish Cancer Institute-Issaquah — Issaquah, Washington, United States
Swedish Medical Center-First Hill — Seattle, Washington, United States
Edwards Comprehensive Cancer Center — Huntington, West Virginia, United States
Aspirus Cancer Care-Antigo-Volm Cancer Center — Antigo, Wisconsin, United States
ThedaCare Regional Cancer Center — Appleton, Wisconsin, United States
Duluth Clinic Ashland — Ashland, Wisconsin, United States
ThedaCare Cancer Care - Berlin — Berlin, Wisconsin, United States
Aurora Cancer Care-Southern Lakes VLCC — Burlington, Wisconsin, United States
Aurora Saint Luke's South Shore — Cudahy, Wisconsin, United States
Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
Mayo Clinic Health System-Eau Claire Clinic — Eau Claire, Wisconsin, United States
Aurora Health Care Germantown Health Center — Germantown, Wisconsin, United States
Aurora Cancer Care-Grafton — Grafton, Wisconsin, United States
Bellin Memorial Hospital — Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Saint Mary's — Green Bay, Wisconsin, United States
Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
Mercyhealth Hospital and Cancer Center - Janesville — Janesville, Wisconsin, United States
Aurora Cancer Care-Kenosha South — Kenosha, Wisconsin, United States
Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
Aurora Bay Area Medical Group-Marinette — Marinette, Wisconsin, United States
Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
Aspirus Medford Hospital — Medford, Wisconsin, United States
Aurora Cancer Care-Milwaukee — Milwaukee, Wisconsin, United States
Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States
Aurora Sinai Medical Center — Milwaukee, Wisconsin, United States
Marshfield Medical Center - Minocqua — Minocqua, Wisconsin, United States
ProHealth D N Greenwald Center — Mukwonago, Wisconsin, United States
ThedaCare Regional Medical Center - Neenah — Neenah, Wisconsin, United States
ThedaCare Cancer Care - New London — New London, Wisconsin, United States
ProHealth Oconomowoc Memorial Hospital — Oconomowoc, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Oconto Falls — Oconto Falls, Wisconsin, United States
ThedaCare Cancer Care - Oshkosh — Oshkosh, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin, United States
Aurora Cancer Care-Racine — Racine, Wisconsin, United States
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center — Rhinelander, Wisconsin, United States
Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
ThedaCare Cancer Care - Shawano — Shawano, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sheboygan — Sheboygan, Wisconsin, United States
Sheboygan Physicians Group — Sheboygan, Wisconsin, United States
Vince Lombardi Cancer Clinic-Sheboygan — Sheboygan, Wisconsin, United States
Aspirus Cancer Care - Stevens Point — Stevens Point, Wisconsin, United States
Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay — Sturgeon Bay, Wisconsin, United States
Aurora Medical Center in Summit — Summit, Wisconsin, United States
Vince Lombardi Cancer Clinic-Two Rivers — Two Rivers, Wisconsin, United States
ProHealth Waukesha Memorial Hospital — Waukesha, Wisconsin, United States
UW Cancer Center at ProHealth Care — Waukesha, Wisconsin, United States
ThedaCare Cancer Care - Waupaca — Waupaca, Wisconsin, United States
Aspirus Cancer Care-Wausau — Wausau, Wisconsin, United States
Aurora Cancer Care-Milwaukee West — Wauwatosa, Wisconsin, United States
Aurora West Allis Medical Center — West Allis, Wisconsin, United States
Marshfield Medical Center - Weston — Weston, Wisconsin, United States
Aspirus Cancer Care - Wisconsin Rapids — Wisconsin Rapids, Wisconsin, United States

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