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RECRUITING Not applicable ClinicalTrials.gov

Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma

Sponsor: Memorial Sloan Kettering Cancer Center • ClinicalTrials.gov ID: NCT06037941

Registry updated: 2026-09-24
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Description

The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure how people respond to standard treatment for malignant pleural mesothelioma (MPM). The researchers will study how E-Nose breathprints change over time as people receive standard treatment for MPM. They will also look at how changes in people's E-Nose breathprints compare to changes in their standard imaging scans and in biomarkers of MPM in their blood.

Interventions

  • E-Nose testing (Diagnostic test)
    At baseline (before any treatment is administered) approximately when the patient is scheduled for a CT of the Chest and/or PET/CT after initiation of any treatment, as medically permissible and at the PI's discretion. A breath sample from each patient will be captured in a cartridge, which will form the basis for the E-Nose analysis, to be performed by study investigators at UCB.
  • Research blood (Diagnostic test)
    Research blood tests will be obtained at baseline and the first three standard of care follow up visits, scheduled by their treating physician along with a CT of the Chest and/or PET/CT1 to determine whether serum biomarkers of MPM.

Eligibility criteria

Inclusion Criteria: * Aged 30-85 years * No history of thoracic cancer or extrathoracic cancer potentially involving pleural metastases (i.e., breast, gastric, colon, or pancreas cancer) * Recent diagnosis of MPM * Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study, and signed standard surgical consent for surgical resection Exclusion Criteria: * Aged \<30 or \>85 years at the first outpatient visit * History of thoracic or extrathoracic cancer that puts the subject at risk for pleural or pulmonary metastases

Conditions

Malignant Pleural Mesothelioma

Locations

  • Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States
  • Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey, United States
  • Memorial Sloan Kettering Bergen (Consent Only ) — Montvale, New Jersey, United States
  • Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent Only) — Commack, New York, United States
  • Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York, United States
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
  • Memorial Sloan Kettering Nassau (Consent Only) — Uniondale, New York, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record