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RECRUITING Phase 2 ClinicalTrials.gov

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

Sponsor: SWOG Cancer Research Network • ClinicalTrials.gov ID: NCT06031688

Registry updated: 2026-10-09
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Description

This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (stage IV) or that has come back after a period of improvement (recurrent). Tepotinib is used in patients whose cancer has a mutated (changed) form of a gene called MET. It is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal MET protein that signals tumor cells to multiply. This helps slow or stop the spread of tumor cells. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Giving tepotinib with ramucirumab may lower the chance of the cancer from growing or spreading in patients with stage IV or recurrent non-small cell lung cancer.

Interventions

  • Biospecimen Collection (Procedure)
    Undergo blood and urine sample collection
  • Computed Tomography (Procedure)
    Undergo CT scan
  • Lymphoscintigraphy (Procedure)
    Undergo lymphoscintigraphy scan
  • Magnetic Resonance Imaging (Procedure)
    Undergo MRI
  • Ramucirumab (Biological)
    Given IV
  • Tepotinib (Drug)
    Given PO

Eligibility criteria

Inclusion Criteria: * Participants must have been assigned to S1900K by the Southwest Oncology Group (SWOG) Statistics and Data Management Center (SDMC). Assignment to S1900K is determined by the LUNGMAP protocol * Participants must have documentation of stage IV or recurrent NSCLC with a MET exon 14 skipping mutation determined by tissue-based or blood-based (circulating tumor DNA \[ctDNA\]) next generation sequencing (NGS) assay done within a laboratory with Clinical Laboratory Improvement Act (CLIA), International Organization for Standardization (ISO)/ International Electrotechnical Commission (IEC), College of American Pathologists (CAP), or similar certification. Documentation must either be: * NGS test results from tissue submitted for LUNGMAP screening, or * Submitted documentation in the LUNGMAP Rave Electronic Data Capture System of a MET exon 14 skipping mutation from a previously completed tissue or blood-based NGS test * Participants must have measurable disease documented by CT or MRI. The CT from a combined positron emission tomography (PET)/CT may be used to document measurable disease ONLY if it is of diagnostic quality, otherwise, it may be used to document non-measurable disease only. Measurable disease must be assessed within 28 days prior to sub-study randomization. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to sub-study randomization. All known sites of disease must be assessed and documented on the Baseline Tumor Assessment Form. Participants whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to sub-study randomization to be considered measurable * Participants must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to sub-study randomization * Participants must not have leptomeningeal disease, spinal cord compression or brain metastases unless: * Metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 3 days following the stereotactic radiation and/or 14 days following whole brain radiation, and prior to sub-study randomization, AND * Participant has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to sub-study randomization * Participants must not have other known actionable oncogenic alterations, such as (but not limited to) EGFR sensitizing mutations, EGFR T790M mutation, ALK gene fusion, ROS1 gene rearrangement, RET gene rearrangement, NTRK rearrangement, HER2 mutation, KRAS activating mutations, and BRAF V600E mutation * Participants who have received at least one line of systemic treatment for stage IV or recurrent NSCLC must have progressed (in the opinion of the treating physician) following the most recent line of therapy. Participants who have not yet received systemic treatment for their stage IV or recurrent NSCLC are allowed * Participants may have received any number of lines of therapy for stage IV or recurrent NSCLC (including zero) and must be able to report prior treatment information * Participants must have recovered (=\< grade 1) from any side effects of prior therapy for NSCLC except alopecia and vitiligo * Participants must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 21 days prior to sub-study randomization * Participants must not have received treatment with prior MET inhibitor therapies (e.g., crizotinib, tivantinib, savolitinib, tepotinib, cabozantinib, and foretinib). * Participants must not have received treatment with prior angiogenesis inhibitor therapies (including but not limited to bevacizumab and ramucirumab) * Participants must not have a history of interstitial lung disease that required steroid treatment * Participants must not have received any radiation therapy within 7 days prior to sub-study randomization with the exceptions of * Stereotactic radiation to CNS metastases which must have been completed at least 3 days prior to sub-study randomization and * Palliative radiotherapy to bone metastases which must have been completed at least 1 day prior to sub-study randomization * Participants must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment while receiving treatment on this study * Participants must not have had a major surgery within 14 days prior to sub-study randomization. Participants must have fully recovered from the effects of prior surgery in the opinion of the treating investigator * Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen * Absolute neutrophil count \>= 1.5 x 10\^3/uL (within 28 days prior to sub-study randomization) * Hemoglobin \>= 9.0 g/dL (within 28 days prior to sub-study randomization) * Platelets \>= 100 x 10\^3/uL (within 28 days prior to sub-study randomization) * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin =\< 5 x institutional ULN (within 28 days prior to sub-study randomization) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 × institutional ULN. Participants with history of liver metastasis must have AST and ALT =\< 5 x ULN (within 28 days prior to sub-study randomization) * Participants must have a serum creatinine =\< the institutional upper limit of normal (IULN) or calculated creatinine clearance \>= 30 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 28 days prior to sub-study randomization * Participants must have a cystatin C test performed to obtain baseline value within 28 days prior to sub-study randomization * Participants' most recent Zubrod performance status must be 0-1 and be documented within 28 days prior to sub-study randomization * Participants must have a completed medical history and physical exam within 28 days prior to sub-study randomization * Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better * Participants with known human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy and have undetectable viral load test on the most recent test results obtained within 6 months prior to sub-study randomization * Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load while on suppressive therapy on the most recent test results obtained within 6 months prior to sub-study randomization, if indicated by the treating investigator * Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants currently being treated for HCV infection must have undetectable HCV viral load test on the most recent test results obtained within 6 months prior to sub-study randomization, if indicated by the treating investigator * Participants must not have cirrhosis at a level of Child-Pugh B (or worse) OR any degree of cirrhosis AND a history of hepatic encephalopathy or clinically meaningful ascites resulting from cirrhosis * Participants must not have grade \< 0 of peripheral edema within 28 days prior to sub-study randomization * Participants must not have experienced any arterial thromboembolic events, including but not limited to transient ischemic attack or cerebrovascular accident within 6 months prior to sub-study randomization * Participants must not have uncontrolled blood pressure and hypertension within 28 days prior to sub-study randomization * Participants must not be pregnant or breastfeeding (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped). Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen * Participants must also be offered participation in specimen banking. With participant consent, specimens must be collected and submitted via the SWOG Specimen Tracking System * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines * NOTE: Participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations

Conditions

Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8

Locations

  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis — Daphne, Alabama, United States
  • Thomas Hospital — Fairhope, Alabama, United States
  • Mobile Infirmary Medical Center — Mobile, Alabama, United States
  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland — Saraland, Alabama, United States
  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas, United States
  • University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
  • Kaiser Permanente-Anaheim — Anaheim, California, United States
  • Sutter Auburn Faith Hospital — Auburn, California, United States
  • Kaiser Permanente-Baldwin Park — Baldwin Park, California, United States
  • Kaiser Permanente-Bellflower — Bellflower, California, United States
  • Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California, United States
  • Tower Cancer Research Foundation — Beverly Hills, California, United States
  • Kaiser Permanente-Fontana — Fontana, California, United States
  • Palo Alto Medical Foundation-Fremont — Fremont, California, United States
  • Kaiser Permanente South Bay — Harbor City, California, United States
  • Kaiser Permanente-Irvine — Irvine, California, United States
  • UC San Diego Moores Cancer Center — La Jolla, California, United States
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
  • Kaiser Permanente West Los Angeles — Los Angeles, California, United States
  • Cedars-Sinai Medical Center — Los Angeles, California, United States
  • Memorial Medical Center — Modesto, California, United States
  • Kaiser Permanente-Ontario — Ontario, California, United States
  • Palo Alto Medical Foundation Health Care — Palo Alto, California, United States
  • Kaiser Permanente - Panorama City — Panorama City, California, United States
  • Eisenhower Medical Center — Rancho Mirage, California, United States
  • Kaiser Permanente-Riverside — Riverside, California, United States
  • Sutter Roseville Medical Center — Roseville, California, United States
  • Sutter Medical Center Sacramento — Sacramento, California, United States
  • University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
  • Kaiser Permanente-San Diego Zion — San Diego, California, United States
  • California Pacific Medical Center-Pacific Campus — San Francisco, California, United States
  • Kaiser Permanente-San Francisco — San Francisco, California, United States
  • Kaiser Permanente-San Marcos — San Marcos, California, United States
  • Mills Health Center — San Mateo, California, United States
  • Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California, United States
  • Sutter Pacific Medical Foundation — Santa Rosa, California, United States
  • Palo Alto Medical Foundation-Sunnyvale — Sunnyvale, California, United States
  • Cedars-Sinai Cancer - Tarzana — Tarzana, California, United States
  • Torrance Memorial Physician Network - Cancer Care — Torrance, California, United States
  • Kaiser Permanente-Vallejo — Vallejo, California, United States
  • Sutter Solano Medical Center/Cancer Center — Vallejo, California, United States
  • Kaiser Permanente-Woodland Hills — Woodland Hills, California, United States
  • UCHealth University of Colorado Hospital — Aurora, Colorado, United States
  • UCHealth Memorial Hospital Central — Colorado Springs, Colorado, United States
  • Memorial Hospital North — Colorado Springs, Colorado, United States
  • Poudre Valley Hospital — Fort Collins, Colorado, United States
  • Cancer Care and Hematology-Fort Collins — Fort Collins, Colorado, United States
  • UCHealth Greeley Hospital — Greeley, Colorado, United States
  • Medical Center of the Rockies — Loveland, Colorado, United States
  • Smilow Cancer Hospital-Derby Care Center — Derby, Connecticut, United States
  • Smilow Cancer Hospital Care Center-Fairfield — Fairfield, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Glastonbury — Glastonbury, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Greenwich — Greenwich, Connecticut, United States
  • Smilow Cancer Hospital Care Center - Guilford — Guilford, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut, United States
  • Yale University — New Haven, Connecticut, United States
  • Yale-New Haven Hospital North Haven Medical Center — North Haven, Connecticut, United States
  • Smilow Cancer Hospital Care Center at Long Ridge — Stamford, Connecticut, United States
  • Smilow Cancer Hospital-Torrington Care Center — Torrington, Connecticut, United States
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull, Connecticut, United States
  • Smilow Cancer Hospital-Waterbury Care Center — Waterbury, Connecticut, United States
  • Smilow Cancer Hospital Care Center - Waterford — Waterford, Connecticut, United States
  • Bayhealth Hospital Kent Campus — Dover, Delaware, United States
  • Bayhealth Hospital Sussex Campus — Milford, Delaware, United States
  • Kaiser Permanente-Capitol Hill Medical Center — Washington D.C., District of Columbia, United States
  • Mayo Clinic in Florida — Jacksonville, Florida, United States
  • Moffitt Cancer Center — Tampa, Florida, United States
  • University Cancer and Blood Center LLC — Athens, Georgia, United States
  • Northeast Georgia Medical Center-Gainesville — Gainesville, Georgia, United States
  • Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Kootenai Clinic Cancer Services - Sandpoint — Sandpoint, Idaho, United States
  • Illinois CancerCare-Bloomington — Bloomington, Illinois, United States
  • Illinois CancerCare-Canton — Canton, Illinois, United States
  • Illinois CancerCare-Carthage — Carthage, Illinois, United States
  • Northwestern University — Chicago, Illinois, United States
  • John H Stroger Jr Hospital of Cook County — Chicago, Illinois, United States
  • Carle at The Riverfront — Danville, Illinois, United States
  • Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
  • Illinois CancerCare-Dixon — Dixon, Illinois, United States
  • Carle Physician Group-Effingham — Effingham, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • Illinois CancerCare-Eureka — Eureka, Illinois, United States
  • Illinois CancerCare-Galesburg — Galesburg, Illinois, United States
  • Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
  • Northwestern Medicine Glenview Outpatient Center — Glenview, Illinois, United States
  • Northwestern Medicine Grayslake Outpatient Center — Grayslake, Illinois, United States
  • Edward Hines Jr VA Hospital — Hines, Illinois, United States
  • Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois, United States
  • Northwestern Medicine Lake Forest Hospital — Lake Forest, Illinois, United States
  • Illinois CancerCare-Macomb — Macomb, Illinois, United States
  • Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
  • Loyola University Medical Center — Maywood, Illinois, United States
  • Cancer Care Center of O'Fallon — O'Fallon, Illinois, United States
  • Northwestern Medicine Oak Brook — Oak Brook, Illinois, United States
  • Northwestern Medicine Orland Park — Orland Park, Illinois, United States
  • Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois, United States
  • Illinois CancerCare-Pekin — Pekin, Illinois, United States
  • Illinois CancerCare-Peoria — Peoria, Illinois, United States
  • Illinois CancerCare-Peru — Peru, Illinois, United States
  • Illinois CancerCare-Princeton — Princeton, Illinois, United States
  • Memorial Hospital East — Shiloh, Illinois, United States
  • Southern Illinois University School of Medicine — Springfield, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Springfield Memorial Hospital — Springfield, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
  • Illinois CancerCare - Washington — Washington, Illinois, United States
  • Northwest Cancer Center - Crown Point — Crown Point, Indiana, United States
  • Northwest Oncology LLC — Dyer, Indiana, United States
  • Saint Mary Medical Center — Hobart, Indiana, United States
  • Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
  • Saint Catherine Hospital — Indianapolis, Indiana, United States
  • The Community Hospital — Munster, Indiana, United States
  • Women's Diagnostic Center - Munster — Munster, Indiana, United States
  • Northwest Cancer Center - Valparaiso — Valparaiso, Indiana, United States
  • Mary Greeley Medical Center — Ames, Iowa, United States
  • McFarland Clinic - Ames — Ames, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Ankeny Clinic — Ankeny, Iowa, United States
  • McFarland Clinic - Boone — Boone, Iowa, United States
  • Physicians' Clinic of Iowa PC — Cedar Rapids, Iowa, United States
  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic — Clive, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Des Moines Clinic — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Laurel Clinic — Des Moines, Iowa, United States
  • McFarland Clinic - Trinity Cancer Center — Fort Dodge, Iowa, United States
  • McFarland Clinic - Jefferson — Jefferson, Iowa, United States
  • McFarland Clinic - Marshalltown — Marshalltown, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Waukee Clinic — Waukee, Iowa, United States
  • University of Kansas Clinical Research Center — Fairway, Kansas, United States
  • HaysMed — Hays, Kansas, United States
  • University of Kansas Cancer Center — Kansas City, Kansas, United States
  • Lawrence Memorial Hospital — Lawrence, Kansas, United States
  • The University of Kansas Cancer Center - Olathe — Olathe, Kansas, United States
  • University of Kansas Cancer Center-Overland Park — Overland Park, Kansas, United States
  • University of Kansas Hospital-Indian Creek Campus — Overland Park, Kansas, United States
  • Salina Regional Health Center — Salina, Kansas, United States
  • University of Kansas Health System Saint Francis Campus — Topeka, Kansas, United States
  • University of Kansas Hospital-Westwood Cancer Center — Westwood, Kansas, United States
  • University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
  • Lafayette Family Cancer Center-EMMC — Brewer, Maine, United States
  • Kaiser Permanente-Woodlawn Medical Center — Baltimore, Maryland, United States
  • Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland, United States
  • Kaiser Permanente - Largo Medical Center — Largo, Maryland, United States
  • Kaiser Permanente Lutherville - Timonium Medical Center — Lutherville, Maryland, United States
  • Lahey Clinic — Burlington, Massachusetts, United States
  • UMass Memorial Medical Center - University Campus — Worcester, Massachusetts, United States
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor — Ann Arbor, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan, United States
  • Trinity Health Medical Center - Brighton — Brighton, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Canton — Canton, Michigan, United States
  • Trinity Health Medical Center - Canton — Canton, Michigan, United States
  • Chelsea Hospital — Chelsea, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital — Chelsea, Michigan, United States
  • Cancer Hematology Centers - Flint — Flint, Michigan, United States
  • Genesee Hematology Oncology PC — Flint, Michigan, United States
  • Genesys Hurley Cancer Institute — Flint, Michigan, United States
  • Hurley Medical Center — Flint, Michigan, United States
  • University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
  • Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
  • Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
  • MyMichigan Medical Center Saginaw — Saginaw, Michigan, United States
  • Oncology Hematology Associates of Saginaw Valley PC — Saginaw, Michigan, United States
  • MyMichigan Medical Center Tawas — Tawas City, Michigan, United States
  • Saint Mary's Oncology/Hematology Associates of West Branch — West Branch, Michigan, United States
  • Huron Gastroenterology PC — Ypsilanti, Michigan, United States
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan, United States
  • Sanford Joe Lueken Cancer Center — Bemidji, Minnesota, United States
  • Essentia Health - Deer River Clinic — Deer River, Minnesota, United States
  • Essentia Health Cancer Center — Duluth, Minnesota, United States
  • Essentia Health Hibbing Clinic — Hibbing, Minnesota, United States
  • Essentia Health Sandstone — Sandstone, Minnesota, United States
  • Essentia Health Virginia Clinic — Virginia, Minnesota, United States
  • Baptist Memorial Hospital and Cancer Center-Golden Triangle — Columbus, Mississippi, United States
  • Baptist Cancer Center-Grenada — Grenada, Mississippi, United States
  • Baptist Memorial Hospital and Cancer Center-Union County — New Albany, Mississippi, United States
  • Baptist Memorial Hospital and Cancer Center-Oxford — Oxford, Mississippi, United States
  • Baptist Memorial Hospital and Cancer Center-Desoto — Southhaven, Mississippi, United States
  • Saint Francis Medical Center — Cape Girardeau, Missouri, United States
  • Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri, United States
  • Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri, United States
  • University Health Truman Medical Center — Kansas City, Missouri, United States
  • Saint Luke's Hospital of Kansas City — Kansas City, Missouri, United States
  • University of Kansas Cancer Center - Briarcliff — Kansas City, Missouri, United States
  • University of Kansas Cancer Center - North — Kansas City, Missouri, United States
  • University of Kansas Cancer Center - Lee's Summit — Lee's Summit, Missouri, United States
  • Saint Luke's East - Lee's Summit — Lee's Summit, Missouri, United States
  • University of Kansas Cancer Center at North Kansas City Hospital — North Kansas City, Missouri, United States
  • Washington University School of Medicine — St Louis, Missouri, United States
  • Mercy Hospital South — St Louis, Missouri, United States
  • Siteman Cancer Center-South County — St Louis, Missouri, United States
  • Siteman Cancer Center at Christian Hospital — St Louis, Missouri, United States
  • Community Hospital of Anaconda — Anaconda, Montana, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
  • Benefis Sletten Cancer Institute — Great Falls, Montana, United States
  • Logan Health Medical Center — Kalispell, Montana, United States
  • Community Medical Center — Missoula, Montana, United States
  • OptumCare Cancer Care at Charleston — Las Vegas, Nevada, United States
  • OptumCare Cancer Care at Fort Apache — Las Vegas, Nevada, United States
  • New Hampshire Oncology Hematology PA-Concord — Concord, New Hampshire, United States
  • Solinsky Center for Cancer Care — Manchester, New Hampshire, United States
  • Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
  • Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
  • Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
  • Virtua Samson Cancer Center — Moorestown, New Jersey, United States
  • Virtua Voorhees — Voorhees Township, New Jersey, United States
  • Memorial Sloan Kettering Commack — Commack, New York, United States
  • Mary Imogene Bassett Hospital — Cooperstown, New York, United States
  • Memorial Sloan Kettering Westchester — Harrison, New York, United States
  • Memorial Sloan Kettering Cancer Center — New York, New York, United States
  • University of Rochester — Rochester, New York, United States
  • Memorial Sloan Kettering Nassau — Uniondale, New York, United States
  • FirstHealth of the Carolinas-Moore Regional Hospital — Pinehurst, North Carolina, United States
  • Sanford Bismarck Medical Center — Bismarck, North Dakota, United States
  • Sanford Broadway Medical Center — Fargo, North Dakota, United States
  • Sanford Roger Maris Cancer Center — Fargo, North Dakota, United States
  • Aultman Health Foundation — Canton, Ohio, United States
  • Miami Valley Hospital South — Centerville, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • Miami Valley Hospital — Dayton, Ohio, United States
  • Premier Blood and Cancer Center — Dayton, Ohio, United States
  • Miami Valley Hospital North — Dayton, Ohio, United States
  • Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
  • Miami Valley Cancer Care and Infusion — Greenville, Ohio, United States
  • ProMedica Flower Hospital — Sylvania, Ohio, United States
  • Upper Valley Medical Center — Troy, Ohio, United States
  • Cancer Centers of Southwest Oklahoma Research — Lawton, Oklahoma, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Providence Newberg Medical Center — Newberg, Oregon, United States
  • Saint Alphonsus Cancer Care Center-Ontario — Ontario, Oregon, United States
  • Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
  • Providence Portland Medical Center — Portland, Oregon, United States
  • Providence Saint Vincent Medical Center — Portland, Oregon, United States
  • Kaiser Permanente Northwest — Portland, Oregon, United States
  • Oregon Health and Science University — Portland, Oregon, United States
  • WellSpan Medical Oncology and Hematology — Chambersburg, Pennsylvania, United States
  • Geisinger Medical Center — Danville, Pennsylvania, United States
  • Geisinger Cancer Center Dickson City — Dickson City, Pennsylvania, United States
  • Ephrata Cancer Center — Ephrata, Pennsylvania, United States
  • Adams Cancer Center — Gettysburg, Pennsylvania, United States
  • Sechler Family Cancer Center — Lebanon, Pennsylvania, United States
  • Geisinger Medical Oncology-Lewisburg — Lewisburg, Pennsylvania, United States
  • UPMC Hillman Cancer Center - Monroeville — Monroeville, Pennsylvania, United States
  • UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
  • Community Medical Center — Scranton, Pennsylvania, United States
  • Geisinger Wyoming Valley/Henry Cancer Center — Wilkes-Barre, Pennsylvania, United States
  • Cancer Care Associates of York — York, Pennsylvania, United States
  • WellSpan Health-York Cancer Center — York, Pennsylvania, United States
  • WellSpan Health-York Hospital — York, Pennsylvania, United States
  • AnMed Health Cancer Center — Anderson, South Carolina, United States
  • Medical University of South Carolina — Charleston, South Carolina, United States
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota, United States
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota, United States
  • Baptist Memorial Hospital and Cancer Center-Collierville — Collierville, Tennessee, United States
  • Baptist Memorial Hospital and Cancer Center-Memphis — Memphis, Tennessee, United States
  • The Don and Sybil Harrington Cancer Center — Amarillo, Texas, United States
  • Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
  • Kaiser Permanente Tysons Corner Medical Center — McLean, Virginia, United States
  • Kaiser Permanente-Caton Hill Medical Center — Woodbridge, Virginia, United States
  • Swedish Cancer Institute-Edmonds — Edmonds, Washington, United States
  • Swedish Cancer Institute-Issaquah — Issaquah, Washington, United States
  • Swedish Medical Center-First Hill — Seattle, Washington, United States
  • Edwards Comprehensive Cancer Center — Huntington, West Virginia, United States
  • West Virginia University Healthcare — Morgantown, West Virginia, United States
  • Duluth Clinic Ashland — Ashland, Wisconsin, United States
  • Marshfield Medical Center-EC Cancer Center — Eau Claire, Wisconsin, United States
  • Gundersen Lutheran Medical Center — La Crosse, Wisconsin, United States
  • Marshfield Medical Center-Marshfield — Marshfield, Wisconsin, United States
  • Marshfield Medical Center - Minocqua — Minocqua, Wisconsin, United States
  • Marshfield Medical Center-Rice Lake — Rice Lake, Wisconsin, United States
  • Marshfield Medical Center-River Region at Stevens Point — Stevens Point, Wisconsin, United States
  • Marshfield Medical Center - Weston — Weston, Wisconsin, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record