Phase 1 Study of Allo-RevCAR01-T-CD123 in Patients With Selected CD123 Positive Hematologic Malignancies (1b Dose Expansion)

Inclusion Criteria (Dose Expansion): 1\. Male or female participants, age ≥18 years. 2. HLA type of participant must match at HLA B and C loci 3. Participants with CD123+ AML with morphologically relapsed or refractory disease (\>5% BM blasts). CD123 positivity is defined as ≥20% of leukemic cells expressing CD123 at any point in the course of disease. 1. Up to third relapse for whom all standard or life-extending therapies have failed and for whom no potentially curative therapies are available or who are intolerant to such therapies. 2. Without prior myeloproliferative neoplasm (MPN) or MDS/MPN (including leukemic transformation of MPN, "blast phase", and "accelerated phase" MPN), and without hyperproliferative disease requiring cytoreductive treatment within 4 weeks from the screening or with WBC above ULN at screening. 3. Exceptions to minimum CD123 expression are not allowed. 4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. 5. Life expectancy of at least 3 months in the judgment of the investigator. 6. Adequate renal and hepatic laboratory assessments. 7. Adequate cardiac function. 8. Long-term central venous access existing (e.g., tunneled CV catheter or port-system) or willing to have such a device inserted to ensure continuous R-TM123 administration. 9\. Able to give written informed consent. 10. Weight is greater than the minimum weight required for a specific batch to ensure that the dose administered does not exceed 10\^5 TCR+ cells/kg of patient weight. 11\. Negative pregnancy; routinely using a highly effective method of birth control. Exclusion Criteria (Dose Expansion): 1. Acute promyelocytic leukemia (t15;17) or myeloproliferative neoplasm (MPN) per WHO 2022 diagnostic criteria. 2. AML with only extramedullary manifestations (e.g., chloroma, primary myeloid sarcoma). 3. Active manifestation of AML in the central nervous system. 4. Bone marrow failure syndromes. 5. Cardiac disease: heart failure (New York Heart Association III or IV); unstable coronary artery disease, myocardial infarction, or serious cardiac ventricular arrhythmias requiring anti-arrhythmic therapy within the last 6 months prior to study entry. 6. Active pulmonary disease with clinically relevant hypoxia (SpO₂ \<92% on room air or daily need for supplemental oxygen). 7. Parkinson's disease or epilepsy with clinical symptoms in the previous 6 months . 8. Stroke, seizure, or intracranial hemorrhage in the past 12 months. 9. History or presence of disseminated intravascular coagulation (DIC), deep vein thrombosis or thromboembolism within 3 months prior to start of treatment. 10. Active infectious disease considered by investigator to be incompatible with protocol or being contraindications for lymphodepletion therapy 11. Presence of hemorrhagic cystitis 12. Other toxicity from prior anticancer treatment has not resolved to Grade ≤1 or baseline. 13. Allogeneic stem cell transplantation within last 2 months or GvHD requiring systemic immunosuppressive therapy. 14. Vaccination with live viruses \< 2 weeks prior to lymphodepletion therapy. 15. Major surgery within 28 days prior to start of R-TM123 infusion. 16. Prior malignancy in the past 3 years or any malignancy requiring ongoing active therapy other than adjuvant endocrine therapy. Participants with malignancy within the last 3 years, but with resected or ablated tumors, such as basal cell carcinoma of skin, carcinoma-in-situ of the cervix, or other tumors considered cured may be considered for the study with Sponsor approval. 17. Treatment with any investigational drug substance or experimental therapy within 4 weeks or 5 half-lives (whichever is shorter) of the substance prior to lymphodepletion. 18. Treatment with anti-leukemic therapy within 4 weeks or 5 half-lives (whichever is shorter) prior to lymphodepletion. 19. Prior treatment with gene modified cell products. 20. Autoimmune diseases requiring systemic steroids or other systemic immunosuppressants. 21. Pregnant or breastfeeding women. 22. Psychologic disorders with treatment modifications required within the last 3 months, drug and/or significant active alcohol abuse as per investigator's medical judgement. Depression or anxiety due to presence of the underlying malignancy may be exempted with Sponsor approval. 23. History of human immunodeficiency virus (HIV) or human T-lymphotropic virus (HTLV) or active/chronic infection with hepatitis C virus (HCV) or hepatitis B virus (HBV). 24. Known presence of autoantibodies against lupus La protein (La)/ Sjögren syndrome type B antigen (SS-B) or presence or history of autoimmune diseases associated with such antibodies. (Results from recent sampling are not required for eligibility unless MH or other facts indicate La/SS-B would likely be positive.) 25. Known hypersensitivity to cellular component (Allo-RevCAR01-T) and/or TM (R-TM123) excipients or to compounds of the lymphodepletion therapy, tocilizumab, or corticosteroids. 26. Evidence that the participant is not likely or able to follow the study protocol (e.g., lacking compliance) in the judgment of the investigator. 27. Participant unable to understand the informed consent and possible consequences of the participation in the clinical trial in the judgment of the investigator.