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RECRUITING Not applicable ClinicalTrials.gov

Cerebellar TMS and Satiety in Prader-Willi Syndrome

Sponsor: Brigham and Women's Hospital • ClinicalTrials.gov ID: NCT05938543

Registry updated: 2026-10-15
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Description

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.

Interventions

  • Repetitive Transcranial Magnetic Stimulation (rTMS) (Device)
    rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces an electrical current in neurons and allows for modulation of neural circuitry. Other Name: iTBS

Eligibility criteria

Inclusion Criteria: * Diagnosis of Prader-Willi syndrome Exclusion Criteria: * contraindications for TMS or MRI including : * history of neurological disorder * history of head trauma resulting in loss of consciousness * history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy * metal in brain or skull * implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI

Conditions

Prader-Willi Syndrome

Locations

  • McLean Hospital — Belmont, Massachusetts, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record