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RECRUITING Phase 3 ClinicalTrials.gov

CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

Sponsor: VA Office of Research and Development • ClinicalTrials.gov ID: NCT05931276

Registry updated: 2026-10-13
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Description

The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.

Interventions

  • Metoprolol Succinate (Drug)
    a dialyzable, beta-1 selective beta blocker
  • Carvedilol (Drug)
    a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties

Eligibility criteria

Inclusion Criteria: * On hemodialysis * Received one of the following beta blockers through the VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, bisoprolol Exclusion Criteria: * Impaired decision-making capacity * Patients not receiving carvedilol who have a history of asthma * known hypersensitivity to any component of either drug * Provider unwilling to sign a new medication order for a randomized patient * No surrogate consent will be allowed

Conditions

End-Stage Kidney Disease End-Stage Renal Disease

Locations

  • VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California, United States
  • Rocky Mountain Regional VA Medical Center, Aurora, CO — Aurora, Colorado, United States
  • VA Connecticut Healthcare System West Haven Campus, West Haven, CT — West Haven, Connecticut, United States
  • North Florida/South Georgia Veterans Health System, Gainesville, FL — Gainesville, Florida, United States
  • Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia, United States
  • Jesse Brown VA Medical Center, Chicago, IL — Chicago, Illinois, United States
  • Iowa City VA Health Care System, Iowa City, IA — Iowa City, Iowa, United States
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston, Massachusetts, United States
  • Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota, United States
  • Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE — Omaha, Nebraska, United States
  • New Mexico VA Health Care System, Albuquerque, NM — Albuquerque, New Mexico, United States
  • Durham VA Medical Center, Durham, NC — Durham, North Carolina, United States
  • Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC — Salisbury, North Carolina, United States
  • Philadelphia MultiService Center, Philadelphia, PA — Philadelphia, Pennsylvania, United States
  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA — Pittsburgh, Pennsylvania, United States
  • VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX — Dallas, Texas, United States
  • VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah, United States
  • VA Puget Sound Health Care System Seattle Division, Seattle, WA — Seattle, Washington, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record