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RECRUITING Not applicable ClinicalTrials.gov

Modulation of Brain Oscillations Underlying Working Memory

Sponsor: Massachusetts General Hospital • ClinicalTrials.gov ID: NCT05923606

Registry updated: 2026-10-07
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Description

This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.

Interventions

  • Active tACS (Device)
    Active tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.
  • Placebo tACS (Device)
    Placebo tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.

Eligibility criteria

Inclusion Criteria: * Able to provide informed consent * Fluent in English. Exclusion Criteria: * History of a neurological/psychiatric disorder * Current use of psychotropic medications * Current use of substances and drugs that were shown to affect tES (transcranial electrical stimulation) efficacy (dopamine altering drugs, nicotine, NMDA (N-methyl-D-aspartate) antagonists/agonists, sodium/calcium channel blockers, norepinephrine reuptake inhibitors, GABAergic modulators and selective serotonin reuptake inhibitors) * Contraindications for tACS (e.g., history of seizures, metallic implants in the head or neck, implanted brain stimulators, vagus nerve stimulators, pacemakers, pregnancy)

Conditions

Working Memory

Locations

  • Martinos Center for Biomedical Imaging — Charlestown, Massachusetts, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record