RECRUITING Phase 4 ClinicalTrials.gov

Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block

Sponsor: Damanhour Teaching Hospital • ClinicalTrials.gov ID: NCT05793060

Registry updated: 2026-09-21

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Description

Background: Many thyroidectomy patients suffer from postoperative pain that could delay early hospital discharge and place a significant burden on both the patient and the healthcare team. Bilateral intermediate cervical plexus block (ICPB) provides good analgesia for neck surgery, including thyroidectomy. However, the duration of a single-shot nerve block is usually short. Therefore, adjuvants are used in peripheral nerve blocks. Objectives: To compare the safety and efficacy of dexmedetomidine versus dexamethasone as adjuvants to bupivacaine in ultrasound-guided intermediate cervical plexus block in patients undergoing total thyroidectomy under general anesthesia. Patients and Methods: This is a randomized, double-blind, phase four, prospective clinical trial; carried out on 60 patients, who were candidates for total thyroidectomy under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received bilateral ICPB with isobaric bupivacaine plus dexmedetomidine, and group B, received bilateral ICPB with isobaric bupivacaine plus dexamethasone.

Interventions

Dexmedetomidine Hydrochloride (Drug)
Dexmedetomidine 50 Mcg
Dexamethasone Phosphate (Drug)
Dexamethasone 4 mg

Eligibility criteria

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 to 60 years * Body Mass Index (BMI) ≤ 35 kg/m2 Exclusion Criteria: * ASA physical status \> II * Age \< 21 years or \> 50 years * BMI \> 35 kg/m2 * Bronchial asthma * Chronic obstructive pulmonary disease * Restrictive lung diseases * Sick sinus syndrome * Sinus bradycardia * Hypertension * Chronic hypotension * Ischemic heart disease * Coagulopathies * Hepatic insufficiency * Renal insufficiency * Diabetes mellitus * Peripheral neuropathy * Thyroid malignancy * Hyperthyroidism * Substernal goiter * Patients on beta-blockers * Patients using pacemakers * Alcohol or drug abuse * Allergy to the study drugs

Conditions

Analgesia

Locations

Damanhour Teaching Hospital — Damanhūr, El-Beheira, Egypt

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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