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RECRUITING Phase 2 ClinicalTrials.gov

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

Sponsor: Memorial Sloan Kettering Cancer Center • ClinicalTrials.gov ID: NCT05789485

Registry updated: 2026-08-25
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Description

The purpose of this study is to find the level of aerobic exercise (AT) that is practical, is safe, and has positive effects on the body that may reduce the side effects of therapy. The study will also look at the way the body responds to exercise and whether there are differences in treatment. This will include looking at the highest treatment dose participants receive, how many people stop, delay, or reduce the treatment, and whether additional medication is needed to treat side effects of therapy.

Interventions

  • structured treadmill walking (Behavioral)
    Three doses of AT (i.e., 90, 150, or 300 mins/week) will be tested. All doses will consist of individualized walking delivered up to 7 times per week delivered throughout treatment.

Eligibility criteria

Inclusion Criteria: * Aged ≥18 years * Diagnosed with colorectal or esophago/gastric solid tumors as defined by one of the following: * Histological confirmation * As per standard of care imaging * Scheduled to receive neoadjuvant chemotherapy or chemotherapy for newly diagnosed metastatic disease * Performing ≤90 minutes of structured moderate-intensity or strenuous-intensity exercise per week, as evaluated by self-report * Willingness to comply with all study-related procedures * Cleared for exercise participation as per screening clearance via the Physical Activity Readiness Questionnaire Exclusion Criteria: * Enrollment onto any other lifestyle interventional investigational study, except interventions determined by the PI not to confound study outcomes * Receiving treatment for any other diagnosis of invasive cancer * Mental impairment leading to inability to cooperate * Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation

Conditions

Gastrointestinal Cancer

Locations

  • Hartford Healthcare Alliance (Data Collection Only) — Hartford, Connecticut, United States
  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States
  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey, United States
  • Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States
  • Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) — Commack, New York, United States
  • Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York, United States
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
  • Memorial Sloan Kettering Nassau (Limited Protocol Activities) — Rockville Centre, New York, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record