N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Not applicable ClinicalTrials.gov

Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function

Sponsor: China-Japan Friendship Hospital • ClinicalTrials.gov ID: NCT05775588

Registry updated: 2026-10-05
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

The goal of this type of study: clinical trial is to evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function. Participants will undergo Lung volume reduction surgery with endobronchial valve implantation.

Interventions

  • Lung volume reduction surgery with endobronchial valve implantation (Procedure)
    the patient would undergo Lung volume reduction surgery with endobronchial valve implantation

Eligibility criteria

Inclusion Criteria: * Patients with Chronic Obstructive Pulmonary Disease * FEV1 ≤ 45% pred and FEV1/FVC\<70% * TLC\>100% pred and RV\>175% pred * CAT score≥18 * Emphysema damage\>50% * Complete interlobar fissure \>95% based on quantitative analysis of CT measurement * No smoking\>6 months * Sign the informed consent form Exclusion Criteria: * PaCO2\>8.0 kPa, or PaO2\<6.0 kPa * 6-minute walk test\<160m * Obvious chronic bronchitis, bronchiectasis or other infectious pulmonary diseases * More than 3 hospitalizations for pulmonary infection in the past 12 months before baseline assessment * Previous lobectomy, LVRS or lung transplantation * LVEF\<45% and or RVSP\>50mmHg * Anticoagulant therapy that cannot be stopped before surgery * Patients with obvious immune deficiency * Participated in other lung drug studies within the first 30 days of this study * Pulmonary nodules requiring intervention * Any disease or condition that interferes with the completion of the initial or subsequent assessment

Conditions

Chronic Obstructive Pulmonary Disease

Locations

  • China-Japan Friendship Hospital — Beijing, Beijing Municipality, China
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record