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RECRUITING Phase 2 ClinicalTrials.gov

Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue

Sponsor: VA Office of Research and Development • ClinicalTrials.gov ID: NCT05584124

Registry updated: 2026-09-14
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Description

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive transcranial magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue and other clinical characteristics related to mood and cognition before and after participants receive rTMS.

Interventions

  • High frequency repetitive transcranial magnetic stimulation (Device)
    MagVenture MagPro X100 with MagOption
  • Sham repetitive transcranial magnetic stimulation (Device)
    MagVenture MagPro X100 with MagOption

Eligibility criteria

Inclusion Criteria: * More than 6 months post-stroke * Clinically present fatigue Exclusion Criteria: * Contraindications to magnetic resonance imaging (MRI)/transcranial magnetic stimulation (TMS)/repetitive transcranial magnetic stimulation (rTMS), e.g., implanted metal within the head, history of seizures * Inability to follow simple three-step instructions * Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe traumatic brain injury (TBI) * Pregnancy * Strokes within stimulation sites * Pregnancy * Severe hypertension (resting systolic blood pressure (SBP) \> 200, DBP \> 120)

Conditions

Stroke Stroke, Chronic Fatigue

Locations

  • Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia, United States
  • Ralph H. Johnson VA Medical Center — Charleston, South Carolina, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record