A2 to O Lung Transplants
Sponsor: University Health Network, Toronto • ClinicalTrials.gov ID: NCT05581745
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Blood group A2 to blood group O kidney and liver transplants have been shown to be safe and successful, especially in recipients with low pre-operative anti-A antibody titers and with the use of peri-operative antibody-depleting therapies. Since blood group O lung transplant candidates tend to have longer wait times and a higher waitlist mortality compared to other blood groups, we propose to conduct a prospective study of lung transplantation from blood group A2 donors to eligible blood group O recipients in an effort to increase the available donor pool. The aim of this study is to determine both the feasibility and safety of this specific type of ABO-incompatible lung transplant, and the impact of this practice on reducing transplant wait times among blood group O lung transplant candidates. This would represent the first prospective study of ABO-incompatible lung transplants worldwide.
Interventions
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Blood group A2 donor to blood group O recipient lung transplant surgery
(Procedure)
Suitable blood group A2 donor lung transplant to a consented blood group O recipient who has acceptably low levels of anti-A antibody titres and a negative virtual cross-match at time of transplant
Eligibility criteria
Conditions
Locations
- Toronto General Hospital, University Health Network — Toronto, Ontario, Canada
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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