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RECRUITING Not applicable ClinicalTrials.gov

The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome

Sponsor: Lund University • ClinicalTrials.gov ID: NCT05554107

Registry updated: 2026-09-03
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Description

Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patients with POTS experience several debilitating symptoms including light-headedness, nausea, blurred vision, fatigue, mental confusion ("brain-fog"), chest pain and gastrointestinal problems. Several potential underlying mechanisms have been suggested for POTS including autonomic denervation, hypovolemia, hyperadrenergic stimulation and autoantibodies against adrenergic receptors. However, none of these proposed mechanisms has yet led to an effective treatment. Physical activity is recommended as a complimentary treatment in POTS in international guidelines. However, less is known regarding how physical activity could successfully be implemented in clinical practice in patients with POTS. Thus, in the current study, we aim to assess the effect of a 16-week specialized physical activity program in POTS.

Interventions

  • Training program (Other)
    A 16-week training program consisting of 2-3 visits per week, and 60 minutes per visit. The program will be done as group exercise under supervision from physiotherapists and/or physicians with special interest in POTS.

Eligibility criteria

Inclusion Criteria: * Patients diagnosed with POTS who have given written informed consent for participation in the study. Exclusion Criteria: * Patients with myalgic encephalomyelitis are excluded from the study.

Conditions

POTS - Postural Orthostatic Tachycardia Syndrome

Locations

  • Skånes Universitetssjukhus Malmö, Department of Cardiology — Malmö, Sweden
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record