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Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE)

Sponsor: Uppsala University • ClinicalTrials.gov ID: NCT05531240

Registry updated: 2026-10-02

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Description

This study focuses on the treatment of benign prostatic hyperplasia which causes lower urinary tract symptoms. The purpose of the research project is to evaluate PAE in terms of both medical and health economic outcomes. To evaluate whether there are any differences in effect (IPSS), complications, costs and perceived quality of life compared with TUR-P.

Interventions

Prostate Artery Embolization (Procedure)
Prostate Artery Embolization (PAE) is performed by experienced interventional radiologists. The method involves catheterization of the prostate vessels superselectively with two to three French microcatheters. PAE is performed with microspheres of 250 to 400 µm in size.
Transurethral Prostate Resection (TURP) (Procedure)
Under general/regional anesthesia, a resectoscope is inserted into the urethra that carries an electric metal loop (monopolar or bipolar diathermy) that is used to cut and extract the prostate tissue.

Eligibility criteria

Inclusion Criteria: * Benign prostatic hyperplasia where medical treatment has not helped or for other reasons has not been deemed applicable * IPSS\>=12 * Prostate volume \[40-100\] ml measured via transrectal ultrasound * Peak flow rate (Qmax) \<= 15 ml / s, * Verified obstruction by urodynamic studies (cystometry) * Surgery not contraindicated Exclusion Criteria: * known prostate or bladder cancer * Severe atherosclerosis * Kidney failure eGFR \< 30 * Urethral stricture * Active cystitis or prostatitis * Bladder stone. * Neurogenic bladder disorder * known allergy to iodinated contrast medium

Conditions

Transurethral Resection of Prostate Syndrome Prostate Hyperplasia Embolization, Therapeutic

Locations

Helsingborgs Hospital — Helsingborg, Region Skånes, Sweden
Mälarsjukhuset — Eskilstuna, Region Sörmland, Sweden
Lasarettet i Enköping — Enköping, Region Uppsala, Sweden
Region Vastmanland Hospital — Västerås, Västmanland County, Sweden

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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