N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Phase 3 ClinicalTrials.gov

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Sponsor: Celgene • ClinicalTrials.gov ID: NCT05519085

Registry updated: 2026-09-30
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Interventions

  • mezigdomide (Drug)
    Specified dose on specified days
  • Pomalidomide (Drug)
    Specified dose on specified days
  • Bortezomib (Drug)
    Specified dose on specified days
  • Dexamethasone (Drug)
    Specified dose on specified days

Eligibility criteria

Inclusion Criteria \- Participant has documented diagnosis of MM and measurable disease, defined as any of the following:. i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or. ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP). iii) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels \> 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio. * Participants received 1 to 3 prior lines of antimyeloma therapy. * Participants achieved minimal response \[MR\] or better to at least 1 prior antimyeloma therapy. Exclusion Criteria \- Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor, except as noted below:. i) Subjects who progressed while being treated with, or within 60 days of last dose of bortezomib maintenance given once every 2 weeks (or less frequently) are not excluded. ii) Participants who progressed while being treated with ixazomib monotherapy maintenance ≥ 6 months prior to the time of starting study treatment are not excluded. * For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity. * Participant has had prior treatment with mezigdomide or pomalidomide. * Other protocol-defined Inclusion/Exclusion criteria apply.

Conditions

Relapsed or Refractory Multiple Myeloma

Locations

  • Local Institution - 0366 — Los Alamitos, California, United States
  • Local Institution - 0272 — San Diego, California, United States
  • Local Institution - 0273 — West Hollywood, California, United States
  • Local Institution - 0381 — Aurora, Colorado, United States
  • Local Institution - 0380 — Farmington, Connecticut, United States
  • Local Institution - 0208 — New Haven, Connecticut, United States
  • Local Institution - 0303 — Coral Springs, Florida, United States
  • Local Institution - 0403 — Fort Myers, Florida, United States
  • Local Institution - 0401 — Orange City, Florida, United States
  • Local Institution - 0402 — West Palm Beach, Florida, United States
  • Local Institution - 0211 — Athens, Georgia, United States
  • Local Institution - 0048 — Marietta, Georgia, United States
  • Local Institution - 0330 — Garden City, Kansas, United States
  • Local Institution - 0080 — Westwood, Kansas, United States
  • Local Institution - 0358 — Baton Rouge, Louisiana, United States
  • Local Institution - 0255 — New Orleans, Louisiana, United States
  • Local Institution - 0385 — Shreveport, Louisiana, United States
  • Local Institution - 0357 — Baltimore, Maryland, United States
  • Local Institution - 0246 — Boston, Massachusetts, United States
  • Local Institution - 0271 — Ann Arbor, Michigan, United States
  • Local Institution - 0364 — Detroit, Michigan, United States
  • Local Institution - 0410 — Minneapolis, Minnesota, United States
  • Local Institution - 0088 — Hattiesburg, Mississippi, United States
  • Local Institution - 0242 — Jackson, Mississippi, United States
  • Local Institution - 0288 — East Brunswick, New Jersey, United States
  • Local Institution - 0363 — Ridgewood, New Jersey, United States
  • Local Institution - 0302 — Albuquerque, New Mexico, United States
  • Local Institution - 0245 — Buffalo, New York, United States
  • Local Institution - 0257 — Lake Success, New York, United States
  • Local Institution - 0373 — New Hyde Park, New York, United States
  • Local Institution - 0371 — New York, New York, United States
  • Local Institution - 0108 — Rochester, New York, United States
  • Local Institution - 0374 — Shirley, New York, United States
  • Local Institution - 0372 — The Bronx, New York, United States
  • Local Institution - 0274 — Williamsville, New York, United States
  • Local Institution - 0260 — Durham, North Carolina, United States
  • Local Institution - 0400 — Cincinnati, Ohio, United States
  • Local Institution - 0377 — Cleveland, Ohio, United States
  • Local Institution - 0076 — Cleveland, Ohio, United States
  • Local Institution - 0376 — Mayfield Heights, Ohio, United States
  • Local Institution - 0359 — Allentown, Pennsylvania, United States
  • Local Institution - 0264 — York, Pennsylvania, United States
  • Local Institution - 0223 — Germantown, Tennessee, United States
  • Local Institution - 0378 — Abilene, Texas, United States
  • Local Institution - 0275 — Houston, Texas, United States
  • Local Institution - 0267 — San Antonio, Texas, United States
  • Local Institution - 0409 — San Antonio, Texas, United States
  • Local Institution - 0207 — Salt Lake City, Utah, United States
  • Local Institution - 0297 — Fredericksburg, Virginia, United States
  • Local Institution - 0408 — Norfolk, Virginia, United States
  • Local Institution - 0399 — Roanoke, Virginia, United States
  • Local Institution - 0268 — Seattle, Washington, United States
  • Local Institution - 0293 — Seattle, Washington, United States
  • Local Institution - 0097 — Spokane, Washington, United States
  • Local Institution - 0411 — Vancouver, Washington, United States
  • Local Institution - 0220 — Madison, Wisconsin, United States
  • Local Institution - 0318 — Chivilcoy, Buenos Aires, Argentina
  • Local Institution - 0213 — Buenos Aires, Buenos Aires F.D., Argentina
  • Local Institution - 0249 — Córdoba, Córdoba Province, Argentina
  • Local Institution - 0239 — Viedma, R, Argentina
  • Local Institution - 0200 — Rosario, Santa Fe Province, Argentina
  • Local Institution - 0248 — S3000epv, Santa Fe Province, Argentina
  • Local Institution - 0214 — Buenos Aires, Argentina
  • Local Institution - 0055 — Liverpool, New South Wales, Australia
  • Local Institution - 0004 — Waratah, New South Wales, Australia
  • Local Institution - 0017 — Wollongong, New South Wales, Australia
  • Local Institution - 0327 — Birtinya, Queensland, Australia
  • Local Institution - 0221 — Box Hill, Victoria, Australia
  • Local Institution - 0003 — Melbourne, Victoria, Australia
  • Local Institution - 0002 — Melbourne, Victoria, Australia
  • Local Institution - 0040 — Nedlands, Western Australia, Australia
  • Local Institution - 0012 — Vienna, State of Vienna, Austria
  • Local Institution - 0008 — Krems, Austria
  • Local Institution - 0024 — Leoben, Austria
  • Local Institution - 0011 — Sankt Pölten, Austria
  • Local Institution - 0025 — Vienna, Austria
  • Local Institution - 0138 — Genk, Limburg, Belgium
  • Local Institution - 0206 — Ghent, Oost-Vlaanderen, Belgium
  • Local Institution - 0179 — Sint-Niklaas, Oost-Vlaanderen, Belgium
  • Local Institution - 0136 — Antwerp, Belgium
  • Local Institution - 0046 — Salvador, Estado de Bahia, Brazil
  • Local Institution - 0044 — Porto Alegre, Rio Grande do Sul, Brazil
  • Local Institution - 0314 — Joinville, Santa Catarina, Brazil
  • Local Institution - 0305 — Jaú, São Paulo, Brazil
  • Local Institution - 0049 — Rio de Janeiro, Brazil
  • Local Institution - 0050 — São Paulo, Brazil
  • Local Institution - 0045 — São Paulo, Brazil
  • Local Institution - 0225 — Greenfield Park, Quebec, Canada
  • Local Institution - 0174 — Montreal, Quebec, Canada
  • Local Institution - 0222 — Québec, Quebec, Canada
  • Local Institution - 0329 — Santiago, Santiago Metropolitan, Chile
  • Local Institution - 0387 — Santiago, Santiago Metropolitan, Chile
  • Local Institution - 0332 — Viña del Mar, Valparaiso, Chile
  • Local Institution - 0062 — Beijing, Beijing Municipality, China
  • Local Institution - 0165 — Beijing, Beijing Municipality, China
  • Local Institution - 0141 — Beijing, Beijing Municipality, China
  • Local Institution - 0144 — Chongqing, Chongqing Municipality, China
  • Local Institution - 0237 — Xiamen, Fujian, China
  • Local Institution - 0117 — Guangzhou, Guangdong, China
  • Local Institution - 0177 — Guangzhou, Guangdong, China
  • Local Institution - 0168 — Guangzhou, Guangdong, China
  • Local Institution - 0238 — Shenzhen, Guangdong, China
  • Local Institution - 0412 — Liuzhou, Guangxi, China
  • Local Institution - 0240 — Nanning, Guangxi, China
  • Local Institution - 0254 — Shijiazhuang, Hebei, China
  • Local Institution - 0395 — Luoyang, Henan, China
  • Local Institution - 0113 — Zhengzhou, Henan, China
  • Local Institution - 0142 — Wuhan, Hubei, China
  • Local Institution - 0155 — Changsha, Hunan, China
  • Local Institution - 0147 — Changsha, Hunan, China
  • Local Institution - 0111 — Nanjing, Jiangsu, China
  • Local Institution - 0139 — Wuxi, Jiangsu, China
  • Local Institution - 0287 — Shenyang, Liaoning, China
  • Local Institution - 0148 — Xi'an, Shaanxi, China
  • Local Institution - 0110 — Xi'an, Shaanxi, China
  • Local Institution - 0169 — Qingdao, Shandong, China
  • Local Institution - 0114 — Shanghai, Shanghai Municipality, China
  • Local Institution - 0350 — Shanghai, Shanghai Municipality, China
  • Local Institution - 0164 — Taiyuan, Shanxi, China
  • Local Institution - 0356 — Deyang, Sichuan, China
  • Local Institution - 0119 — Tianjin, Tianjin Municipality, China
  • Local Institution - 0353 — Ürümqi, Xinjiang, China
  • Local Institution - 0202 — Kunming, Yunnan, China
  • Local Institution - 0151 — Hangzhou, Zhejiang, China
  • Local Institution - 0348 — Linhai, Zhejiang, China
  • Local Institution - 0112 — Ningbo, Zhejiang, China
  • Local Institution - 0149 — Wenzhou, Zhejiang, China
  • Local Institution - 0150 — Beijing, China
  • Local Institution - 0176 — Taiyuan, China
  • Local Institution - 0037 — Brno, Brno-město, Czechia
  • Local Institution - 0383 — Prague, Praha 10, Czechia
  • Local Institution - 0039 — Prague, Czechia
  • Local Institution - 0256 — Kuopio, Northern Savonia, Finland
  • Local Institution - 0072 — Helsinki, Finland
  • Local Institution - 0091 — Pessac, Aquitaine, France
  • Local Institution - 0205 — Lyon Cedex08, Auvergne-Rhône-Alpes, France
  • Local Institution - 0146 — Lille, Nord, France
  • Local Institution - 0116 — Clermont-Ferrand, France
  • Local Institution - 0167 — Limoges, France
  • Local Institution - 0043 — Nantes, France
  • Local Institution - 0216 — Nîmes, France
  • Local Institution - 0175 — Strasbourg, France
  • Local Institution - 0188 — Tours, France
  • Local Institution - 0115 — Paris, Île-de-France Region, France
  • TUM Klinikum — München, Bavaria, Germany
  • Klinikum Traunstein — Traunstein, Bavaria, Germany
  • Medizinisches Versorgungszentrum — Weiden, Bavaria, Germany
  • Universitaetsklinik Marburg — Marburg, Hesse, Germany
  • Praxis Onkologie am Raschplatz — Hanover, Lower Saxony, Germany
  • Universitätsklinikum Bonn — Bonn, North Rhine-Westphalia, Germany
  • Marien Hospital Düsseldorf — Düsseldorf, North Rhine-Westphalia, Germany
  • Universitaetsklinikum Schleswig-Holstein Campus Kiel — Kiel, Schleswig-Holstein, Germany
  • Local Institution - 0396 — Erfurt, Thuringia, Germany
  • Universitätsklinikum Aachen — Aachen, Germany
  • Sozialstiftung Bamberg — Bamberg, Germany
  • Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf — Dresden, Germany
  • Universitaetsklinikum Hamburg-Eppendorf — Hamburg, Germany
  • Asklepios Altona — Hamburg, Germany
  • Universitaetsklinikum Tuebingen — Tübingen, Germany
  • Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher — Würzburg, Germany
  • Local Institution - 0190 — Athens, Attikí, Greece
  • Local Institution - 0191 — Athens, Attikí, Greece
  • G. Papanikolaou General Hospital — Thessaloniki, Thessaloníki, Greece
  • HCG Aastha Cancer Centre — Ahmedabad, Gujarat, India
  • Marengo Asia Hospitals Gurugram — Gurugram, Haryana, India
  • KLES Dr. Prabhakar Kore Hospital & M.R.C — Belagavi, Karnataka, India
  • Mumbai Oncocare Centre - Nanachowk — Mumbai, Maharashtra, India
  • Local Institution - 0344 — Madurai, Tamil Nadu, India
  • Local Institution - 0341 — Varanasi, Uttar Pradesh, India
  • Christian Medical College & Hospital — Ludhiana, India
  • Jawaharlal Institute Of Postgraduate Medical Education And Research — Puducherry, India
  • Local Institution - 0121 — Galway, Connacht, Ireland
  • Local Institution - 0122 — Cork, Ireland
  • Local Institution - 0120 — Dublin, Ireland
  • Local Institution - 0251 — Limerick, Ireland
  • Local Institution - 0196 — Kfar Saba, Central District, Israel
  • Local Institution - 0195 — Ramat Gan, Central District, Israel
  • Local Institution - 0197 — Jerusalem, Jerusalem, Israel
  • Local Institution - 0192 — Haifa, Northern District, Israel
  • Local Institution - 0193 — Tel Aviv, Tall Abīb, Israel
  • Local Institution - 0194 — Peatch Tikva, Israel
  • Local Institution - 0384 — Meldola, Emilia-Romagna, Italy
  • Local Institution - 0212 — Rome, Roma, Italy
  • Local Institution - 0160 — Catania, Sicily, Italy
  • Local Institution - 0159 — Bologna, Italy
  • Local Institution - 0158 — Pavia, Italy
  • Local Institution - 0281 — Kashiwa, Chiba, Japan
  • Local Institution - 0278 — Kitakyushu-shi, Fukuoka, Japan
  • Local Institution - 0280 — Sapporo, Hokkaido, Japan
  • Local Institution - 0417 — Higashiibaraki, Ibaraki, Japan
  • Local Institution - 0276 — Shiwa-gun Yahaba-cho, Iwate, Japan
  • Local Institution - 0294 — Kamakura, Kanagawa, Japan
  • Local Institution - 0290 — Iruma, Saitama, Japan
  • Local Institution - 0285 — Koshigaya, Saitama, Japan
  • Local Institution - 0289 — Nagaizumi-cho,Sunto-gun, Shizuoka, Japan
  • Local Institution - 0296 — Itabashiku, Tokyo, Japan
  • Local Institution - 0283 — Shibuya-ku, Tokyo, Japan
  • Local Institution - 0279 — Chiba, Japan
  • Local Institution - 0286 — Fukuoka, Japan
  • Local Institution - 0295 — Fukuoka, Japan
  • Local Institution - 0291 — Hiroshima, Japan
  • Local Institution - 0284 — Kumamoto, Japan
  • Local Institution - 0277 — Nagasaki, Japan
  • Local Institution - 0300 — Tokyo, Japan
  • Local Institution - 0335 — Tauranga, Bay of Plenty, New Zealand
  • Local Institution - 0340 — Dunedin, Otago, New Zealand
  • Local Institution - 0369 — Auckland, New Zealand
  • Local Institution - 0334 — Auckland, New Zealand
  • Local Institution - 0346 — Skórzewo, Greater Poland Voivodeship, Poland
  • Local Institution - 0224 — Torun, Kuyavian-Pomeranian Voivodeship, Poland
  • Local Institution - 0325 — Krakow, Lesser Poland Voivodeship, Poland
  • Local Institution - 0250 — Warsaw, Masovian Voivodeship, Poland
  • Local Institution - 0292 — Słupsk, Pomeranian Voivodeship, Poland
  • Local Institution - 0185 — Katowice, Poland
  • Hospital de Braga — Braga, Portugal
  • Champalimaud Foundation — Lisbon, Portugal
  • Instituto Português de Oncologia do Porto Francisco Gentil, EPE — Porto, Portugal
  • Local Institution - 0355 — San Juan, Puerto Rico
  • Local Institution - 0021 — Bucharest, Romania
  • Local Institution - 0052 — Cluj-Napoca, Romania
  • Local Institution - 0035 — Iași, Romania
  • Local Institution - 0405 — Centurion, GP, South Africa
  • Local Institution - 0404 — Cape Town, Western Cape, South Africa
  • Local Institution - 0407 — Kuilsriver, Western Cape, South Africa
  • Local Institution - 0406 — Plumstead, Western Cape, South Africa
  • Local Institution - 0106 — Busan, Busan, South Korea
  • Pusan National University Hospital — Busan, Busan, South Korea
  • Local Institution - 0102 — Seongnam, Gyeonggido, South Korea
  • Seoul National University Bundang Hospital — Seongnam, Gyeonggido, South Korea
  • Chonnam National University Hwasun Hospital — Hwasun, Jeonranamdo, South Korea
  • Local Institution - 0103 — Hwasun, Jeonranamdo, South Korea
  • Local Institution - 0101 — Seoul, Seoul Teugbyeolsi, South Korea
  • Seoul National University Hospital — Seoul, Seoul Teugbyeolsi, South Korea
  • Samsung Medical Center — Seoul, Seoul Teugbyeolsi, South Korea
  • Local Institution - 0104 — Seoul, Seoul Teugbyeolsi, South Korea
  • The Catholic Univ. of Korea Seoul St. Mary's Hospital — Seoul, Seoul Teugbyeolsi, South Korea
  • Asan Medical Center — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
  • Local Institution - 0105 — Seoul, Seoul-teukbyeolsi, South Korea
  • Local Institution - 0100 — Seoul, South Korea
  • Severance Hospital, Yonsei University Health System — Seoul, South Korea
  • Local Institution — Seoul, South Korea
  • Local Institution - 0183 — Palma, Balearic Islands, Spain
  • Local Institution - 0252 — Palma, Balears [Baleares], Spain
  • Local Institution - 0073 — Barcelona, Catalunya [Cataluña], Spain
  • Local Institution - 0210 — Barcelona, Catalunya [Cataluña], Spain
  • Local Institution - 0075 — Murcia, Murcia, Región de, Spain
  • Local Institution - 0182 — Marbella, Málaga, Spain
  • Local Institution - 0253 — Marbella, Málaga, Spain
  • Local Institution - 0328 — Cáceres, Spain
  • Local Institution - 0074 — León, Spain
  • Local Institution - 0181 — Madrid, Spain
  • Local Institution - 0232 — Ankara, Turkey (Türkiye)
  • Local Institution - 0339 — Ankara, Turkey (Türkiye)
  • Local Institution - 0228 — Istanbul, Turkey (Türkiye)
  • Local Institution - 0229 — Izmir, Turkey (Türkiye)
  • Local Institution - 0226 — Kayseri, Turkey (Türkiye)
  • Local Institution - 0227 — Samsun, Turkey (Türkiye)
  • Addenbrooke's Hospital — Cambridge, Cambridgeshire, United Kingdom
  • The Royal Cornwall Hospital — Truro, England, United Kingdom
  • Lanarkshire NHS Trust - Monklands Hospital — Airdrie, Great Britain, United Kingdom
  • King's College Hospital — London, Greater London, United Kingdom
  • Leicester Royal Infirmary — Leicester, Leicestershire, United Kingdom
  • Hammersmith Hospital — London, London, City of, United Kingdom
  • Barnet Hospital — Barnet, United Kingdom
  • Freeman Hospital — Newcastle upon Tyne, United Kingdom
  • Royal Stoke University Hospital — Stoke-on-Trent, United Kingdom
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record