Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Sponsor: State University of New York at Buffalo • ClinicalTrials.gov ID: NCT05500170
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Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
Interventions
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Nicotinamide riboside
(Dietary supplement)
Nicotinamide riboside (NR) is a form of vitamin B3, which is found in fruits, vegetables, meat, and milk. NR is converted into nicotinamide adenosine dinucleotide NAD+. Low NAD+ levels have been linked to Alzheimer's disease and sleep disturbances.
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Placebo
(Dietary supplement)
The placebo pill will contain micro cellulose powder.
Eligibility criteria
Conditions
Locations
- State University of New York at Buffalo — Buffalo, New York, United States
- University at Buffalo State University of New York — Buffalo, New York, United States
- Buffalo Veteran Affairs Medical Center — Buffalo, New York, United States
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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