Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Sponsor: University of Minnesota • ClinicalTrials.gov ID: NCT05493722
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Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.
Interventions
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Physician-Selected Settings Stimulation
(Other)
Participants will receive deep brain stimulation using physician-selected settings
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Optimized Settings Stimulation
(Other)
Participants will receive deep brain stimulation using optimized settings determined through setting optimization.
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DBS Setting Optimization
(Other)
Participants with electrodes in a thalamic location other than the anterior nucleus of the thalamus will undergo deep brain stimulation setting optimization but will not be randomized to one of the three stimulation-sequence groups.
Eligibility criteria
Conditions
Locations
- University of Minnesota — Minneapolis, Minnesota, United States
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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