Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

Description

This is a two-part, phase 2b and phase 3 combined prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1: Phase 2b is a dose-finding study for CSL300 vs placebo. Part 2: Phase 3 aims to assess the efficacy of CSL300 vs placebo on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.

Interventions

• CSL300 (Drug)
  IV administration
• Placebo (Drug)
  Matching the excipient content and concentration of the CSL300 product, minus the active ingredient.

Eligibility criteria

Conditions

Locations

• Nephrology of North Alabama — Decatur, Alabama, United States
• Nephrology Consultants, LLC — Huntsville, Alabama, United States
• DaVita Clinical Research Montgomery — Montgomery, Alabama, United States
• AKDHC Medical — Glendale, Arizona, United States
• Kidney Disease Medical Group — Glendale, Arizona, United States
• AKDHC Medical — Phoenix, Arizona, United States
• AKDHC Medical — Tucson, Arizona, United States
• Southern Arizona VA Health Care System — Tucson, Arizona, United States
• National Institute of Clinical Research — Bakersfield, California, United States
• Amicis Research Center — Beverly Hills, California, United States
• California Institute of Renal Research — Chula Vista, California, United States
• The Medical Research Group, Inc. — Fresno, California, United States
• Davita Fullerton Dialysis Center — Fullerton, California, United States
• National Institute of Clinical Research, Inc. — Fullerton, California, United States
• National Institute of Clinical Research, Inc. — Garden Grove, California, United States
• St. Jude Medical Center — Garden Grove, California, United States
• National Institute of Clinical Research — Garden Grove, California, United States
• Sherman Medical Group, Inc — Glendale, California, United States
• Kidney Disease Medical Group — Glendale, California, United States
• Renal Consultants Medical Group — Granada Hills, California, United States
• Balboa Research — La Jolla, California, United States
• California Institute of Renal Research — La Mesa, California, United States
• Southern California Medical Research Center — La Palma, California, United States
• Academic Medical Research Institute — Los Angeles, California, United States
• National Institute of Clinical Research, Inc. — Los Angeles, California, United States
• DaVita Carabello Dialysis Center — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Renal Medical Associates/NARI — Lynwood, California, United States
• Amicis Research Center — Northridge, California, United States
• FORMAT Medical Research — Oxnard, California, United States
• National Institute of Clinical Research, Inc. — Pomona, California, United States
• Van Buren Dialysis Center — Riverside, California, United States
• National Nephrology Alliance Research - Riverside — Riverside, California, United States
• Central Coast Nephrology Medical Corp — Salinas, California, United States
• California Institute of Renal Research — San Diego, California, United States
• California Institute of Renal Research — San Diego, California, United States
• North America Research Institute — San Dimas, California, United States
• Satellite Healthcare — San Jose, California, United States
• Nephrology Educational Services — Tarzana, California, United States
• Valiance Clinical Research — Tarzana, California, United States
• Amicis Research Center — Vacaville, California, United States
• National Institute of Clinical Research, Inc — Victorville, California, United States
• DaVita Vista Del Sol Dialysis — Victorville, California, United States
• Western Nephrology — Arvada, Colorado, United States
• Kidney Associates of Colorado, P.C. — Denver, Colorado, United States
• Colorado Kidney Care — Denver, Colorado, United States
• Greater Hartford Nephrology, LLC — Bloomfield, Connecticut, United States
• Nephrology and Hypertension Associates PC — Middlebury, Connecticut, United States
• Nephrology Associates (Delaware) — Newark, Delaware, United States
• - Boca Raton Regional - Research Physicians Network Alliance — Boca Raton, Florida, United States
• Nova Clinical Research, LLC — Bradenton, Florida, United States
• Access Research Institute — Brooksville, Florida, United States
• Horizon Research Group LLC — Coral Gables, Florida, United States
• South Florida Nephrology Group, PA — Coral Springs, Florida, United States
• Family First Medical Research Center — Hialeah Gardens, Florida, United States
• Advanced Medical Research Group — Hollywood, Florida, United States
• Royal Research, Corp — Hollywood, Florida, United States
• Elixia Pines — Hollywood, Florida, United States
• South Florida Research Institute — Lauderdale Lakes, Florida, United States
• South Florida Research Organization LLC — Medley, Florida, United States
• Aviva Health Sciences — Miami, Florida, United States
• Iconic Clinical Research Center — Miami, Florida, United States
• Total Research Group, LLC — Miami, Florida, United States
• Kidney and Hypertension Specialists of Miami — Miami, Florida, United States
• Nephrology Associates of South Miami — Miami, Florida, United States
• Floridian Clinical Research — Miami Lakes, Florida, United States
• Elixia Central Florida — Orlando, Florida, United States
• Infigo Clinical Research LLC — Sanford, Florida, United States
• Genesis Clinical Research — Tampa, Florida, United States
• Florida Kidney Specialists — Temple Terrace, Florida, United States
• Florida Premier Research Institute — Winter Park, Florida, United States
• Southwest Georgia Nephrology Clinic — Albany, Georgia, United States
• Coastal Medical Research, LLC — Brunswick, Georgia, United States
• Renal Associates LLC — Columbus, Georgia, United States
• National Clinical Trials — Cordele, Georgia, United States
• American Clinical Trials — Douglasville, Georgia, United States
• Georgia Nephrology — Lawrenceville, Georgia, United States
• Atekha Nephrology Clinic LLC — Statesboro, Georgia, United States
• NANI Research — Fort Wayne, Indiana, United States
• Nephrology Physician's LLC — Mishawaka, Indiana, United States
• Dunes Clinical Research LLC — Sioux City, Iowa, United States
• Kansas Nephrology Physicians, PA — Wichita, Kansas, United States
• Nephrology Associates of Kentuckiana, PSC — Louisville, Kentucky, United States
• Renal Associates of Baton Rouge — Baton Rouge, Louisiana, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Paragon Health, Inc — Kalamazoo, Michigan, United States
• Michigan Kidney Consultants, PC — Pontiac, Michigan, United States
• St. Clair Nephrology Research — Roseville, Michigan, United States
• Center for Advanced Kidney Research, PLC — Saint Clair Shores, Michigan, United States
• DCR Edina — Minneapolis, Minnesota, United States
• DCR Edina — Minneapolis, Minnesota, United States
• Minneapolis VA Health Care System — Minneapolis, Minnesota, United States
• Southwest Mississippi Nephrology PLLC — Brookhaven, Mississippi, United States
• Nephrology Associates, PC — Columbus, Mississippi, United States
• - Nephrology and Hypertension Associates Ltd — Tupelo, Mississippi, United States
• Clinical Research Consultants — Kansas City, Missouri, United States
• Kansas City VA Medical Center — Kansas City, Missouri, United States
• DCI-Rockhill — Kansas City, Missouri, United States
• GSR Enterprises, Inc. — Lincoln, Nebraska, United States
• Great Plains Health - Nephrology — North Platte, Nebraska, United States
• DaVita Clinical Research - Henderson — Henderson, Nevada, United States
• Kidney Specialists of Southern Nevada — Las Vegas, Nevada, United States
• Sierra Nevada Specialty Care — Reno, Nevada, United States
• Seacoast Kidney and Hypertension Specialists — Portsmouth, New Hampshire, United States
• Hypertension & Nephrology Association — Eatontown, New Jersey, United States
• New Jersey Kidney Care — Jersey City, New Jersey, United States
• U.S. Renal Care - Gallup — Gallup, New Mexico, United States
• Albany Medical College Committee of Research Involving Human Subjects — Albany, New York, United States
• SUNY Downstate Medical Center Brooklyn — Brooklyn, New York, United States
• Mattoo & Bhat Medical Associates, P.C. — College Point, New York, United States
• NYU Langone Hospital - Long Island — Mineola, New York, United States
• DaVita Clinic Research Bronx — The Bronx, New York, United States
• Albert Einstein College of Medicine - Montefiore Medical Center — The Bronx, New York, United States
• James J Peters VA Medical Center — The Bronx, New York, United States
• Metrolina Nephrology Associates, PA — Charlotte, North Carolina, United States
• Durham Nephrology Associates, PA — Durham, North Carolina, United States
• Duke Translational Medicine Institute — Durham, North Carolina, United States
• East Carolina University — Greenville, North Carolina, United States
• Eastern Nephrology Associates, PLLC — Kinston, North Carolina, United States
• North Carolina Nephrology, PA — Raleigh, North Carolina, United States
• Nephrology Associates of the Carolinas — Shelby, North Carolina, United States
• HNC Dialysis, Ltd. — Columbus, Ohio, United States
• Northeast Clinical Research Center, LLC — Bethlehem, Pennsylvania, United States
• Clinical Renal Associates, LTD — Exton, Pennsylvania, United States
• Lifespan Clinical Research — East Providence, Rhode Island, United States
• Columbia Nephrology — Columbia, South Carolina, United States
• CN Clinical Research LLC — Greenville, South Carolina, United States
• Dialysis Clinic, Inc. — Spartanburg, South Carolina, United States
• DaVita Clinical Research — Spartanburg, South Carolina, United States
• Southeast Renal Research Institute — Chattanooga, Tennessee, United States
• Dialysis Clinic Inc - University Nephology — Knoxville, Tennessee, United States
• Knoxville Kidney Center PLLC — Knoxville, Tennessee, United States
• Lt. Col. Luke Weathers, Jr. VA Medical Center — Memphis, Tennessee, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Cussimanio Research Group LLC — Austin, Texas, United States
• Research Management, Inc. — Austin, Texas, United States
• MW Clinical Research Center — Beaumont, Texas, United States
• Dallas V.A. Medical Center — Dallas, Texas, United States
• Dallas Nephrology Associates — Dallas, Texas, United States
• US Renal Care — Dallas, Texas, United States
• Davita Clinical Research — El Paso, Texas, United States
• DaVita Clinical Research - Horizon — El Paso, Texas, United States
• Fort Worth Renal Group — Fort Worth, Texas, United States
• Clinical Research Strategies — Houston, Texas, United States
• DaVita Clinical Research — Houston, Texas, United States
• Aqua Research Institute — Houston, Texas, United States
• Gulf Coast Clinical Research — Houston, Texas, United States
• Houston Medical Research Institute, LLC — Houston, Texas, United States
• Clinical Research Strategies, Inc. — Houston, Texas, United States
• Southwest Houston Research — Houston, Texas, United States
• Laguna Clinical Research Associates, LLC — Laredo, Texas, United States
• Prime Clinical Research, Inc. — Mansfield, Texas, United States
• Gamma Medical Research, Inc. — McAllen, Texas, United States
• National Institute of Clinical Research, Inc. — San Antonio, Texas, United States
• DaVita Clinical Research — San Antonio, Texas, United States
• Davita Clinical Research — San Antonio, Texas, United States
• DCR-San Antonio Stone Oak — San Antonio, Texas, United States
• DaVita Clinical Research North Houston — Shenandoah, Texas, United States
• Medrasa Clinical Research — Sherman, Texas, United States
• Renal Research of Montgomery County — The Woodlands, Texas, United States
• DCR-Norfolk Great Bridge — Chesapeake, Virginia, United States
• Nephrology Associates of Northern Virginia Inc — Fairfax, Virginia, United States
• Peninsula Kidney Associates — Hampton, Virginia, United States
• Tidewater Kidney Specialists — Norfolk, Virginia, United States
• Richmond V.A. Medical Center — Richmond, Virginia, United States
• Nephrology and Hypertension Associates — Bluefield, West Virginia, United States
• FME Lomas de Zamora — Banfield, Argentina
• FME Mansilla — Buenos Aires, Argentina
• Instituto de Trasplante De La Ciudad Autonoma De Buenos Aires — Buenos Aires, Argentina
• FME Avellaneda — Buenos Aires, Argentina
• FME Cemic Saavedra — Ciudad Autonoma, Argentina
• CEREHA — Ciudad de Buenos Aires, Argentina
• Fresenius Medical Care - Ciudad Evita — Ciudad Evita, Argentina
• Clinica Privada Velez Sarsfield — Córdoba, Argentina
• FME Formosa — Formosa, Argentina
• STR Hurlingham SRL — Hurlingham, Argentina
• Nextdial S.A. — Mar del Plata, Argentina
• Fresenius Medical Care - Nostri Centri Dialisi - Moron — Morón, Argentina
• Instituto Medico de la Fundacion de Estudios Clínicos — Rosario, Argentina
• FME San Fernando — San Fernando, Argentina
• Fresenius Tucumán — San Miguel de Tucumán, Argentina
• Clínica de Nefrología, Urología y Enfermedades Cardiovasculares — Santa Fe, Argentina
• Royal North Shore Hospital (RNSH) — Saint Leonards, New South Wales, Australia
• Concord Repatriation General Hospital — Sydney, New South Wales, Australia
• Cairns Hospital — Cairns, Queensland, Australia
• Sunshine Coast University Private Hospital — Nambour, Queensland, Australia
• Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
• Monash Medical Centre — Clayton, Victoria, Australia
• Sunshine Hospital — St Albans, Victoria, Australia
• Wide Bay Hospital and Health Service — Bundaberg, Australia
• Austin Hospital — Heidelberg, Australia
• Liverpool Hospital — Liverpool, Australia
• Fiona Stanley Hospital — Murdoch, Australia
• Sunshine Coast University Private Hospital — Nambour, Australia
• Royal Melbourne Hospital — Parkville, Australia
• Gold Coast University Hospital — Southport, Australia
• Fraser Coast Renal Service, Hervey Bay Hospital — Urraween, Australia
• Sydney Adventist Hospital — Wahroonga, Australia
• Westmead Hospital — Westmead, Australia
• Wollongong Renal Unit — Wollongong, Australia
• Wiener Gesundheitsverbund - Klinik Hietzing — Vienna, Austria
• Onze-Lieve-Vrouwziekenhuis VZW — Aalst, Belgium
• Imelda Ziekenhuis — Bonheiden, Belgium
• Centre Hospitalier Universitaire (CHU) de Charleroi - Hopital Civil Marie Curie — Charleroi, Belgium
• AZ Sint-Lucas — Ghent, Belgium
• Centre Hospitalier Universitaire de Tivoli — La Louvière, Belgium
• Jan Yperman Ziekenhuis — Leper, Belgium
• Universitair Ziekenhuis Leuven — Leuven, Belgium
• CHR de la Citadelle — Liège, Belgium
• AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke — Roeselare, Belgium
• VITAZ, Department Nierziekten & Dialyse — Sint-Niklaas, Belgium
• Santa Casa de Misericordia de Belo Horizonte — Belo Horizonte, Brazil
• NUPEC-Nucleo de Pesquisa Clinica — Belo Horizonte, Brazil
• Hospital Universitário Walter Cantídio (Fortaleza) — Fortaleza, Brazil
• Empresa Brasileira de Serviços Hospitalares (EBSERH) — Goiânia, Brazil
• Fundacao Pro Rim de Santa Catarina — Joinville, Brazil
• Clipem - Clínica o Pesquisa Endocrinológica de Maringá — Maringá, Brazil
• Instituto Atena de Pesquisa Clinica — Natal, Brazil
• Hospital de Clinicas de Passo Fundo — Passo Fundo, Brazil
• Irmandade Santa Casa de Misericordia de Porto Alegre — Porto Alegre, Brazil
• Hospital de Clinicas de Porto Alegre — Porto Alegre, Brazil
• Hospital São Lucas da PUCRS — Porto Alegre, Brazil
• CEDOES - Centro de Diagnostico e Pesquisa — Praia Do Canto, Brazil
• Universidade de Sao Paulo (USP)-Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP) — Ribeirão Preto, Brazil
• SERVIÇO DE NEFROLOGIA DE RIBEIRÃO Preto (SENERP) — Ribeirão Preto, Brazil
• Secretaria da Saúde do Estado da Bahia (SESAB) — Salvador, Brazil
• Clinica Senhor do Bonfim Ltda (CSB) - Monte Serrat — Salvador, Brazil
• Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto — São José do Rio Preto, Brazil
• Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo — São Paulo, Brazil
• Hospital Alemao Oswaldo Cruz — São Paulo, Brazil
• Hospital do Rim e Hipertensão — São Paulo, Brazil
• Trialstar-Centro de Pesquisa Clinicas — São Paulo, Brazil
• Hospital Santa Marcelina — São Paulo, Brazil
• Hospital 9 de Julho — São Paulo, Brazil
• Multiprofile Hospital for Active Treatment - Dobrich AD — Dobrich, Bulgaria
• Multiprofile Hospital For Active Treatment Dr Tota Venkova — Gabrovo, Bulgaria
• Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD — Lom, Bulgaria
• Dialysis Centre Montana — Montana, Bulgaria
• University Multiprofile Hospital for Active Treatment Sveti Georgi EAD — Plovdiv, Bulgaria
• UMHAT Plovdiv — Plovdiv, Bulgaria
• Multiprofile Hospital for Active Treatment Dr. Ivan Seliminski - Sliven AD — Sliven, Bulgaria
• Medical Center - Smolyan OOD — Smolyan, Bulgaria
• UMHAT Aleksandrovska — Sofia, Bulgaria
• University Hospital for Active Treatment Tsaritsa Joanna ISUL EAD — Sofia, Bulgaria
• Dialysis Center VIA DIAL OOD — Stara Zagora, Bulgaria
• UMHAT Prof. Dr. Stoyan Kirkovich — Stara Zagora, Bulgaria
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Queen Elizabeth II Health Sciences Centre — Halifax, Nova Scotia, Canada
• St. Josephs Healthcare Hamilton — Hamilton, Ontario, Canada
• Kingston Health Sciences Centre — Kingston, Ontario, Canada
• London Health Sciences Centre - University Hospital — London, Ontario, Canada
• Lakeridge Health Oshawa — Oshawa, Ontario, Canada
• McGill University Health Centre — Montreal, Quebec, Canada
• Hôpital du Sacré-Cœur-de-Montréal — Montreal, Quebec, Canada
• Hospital Charles Lemoyne — Longueuil, Canada
• Maisonneuve-Rosemont Hospital — Montreal, Canada
• CHUM - Centre hospitalier de l'Universite de Montreal — Montreal, Canada
• The Ottawa Hospital Research Institute — Ottawa, Canada
• Ciussse-Chus — Sherbrooke, Canada
• St. Michaels Hospital — Toronto, Canada
• St Paul Hospital — Vancouver, Canada
• Seven Oaks Hospital — Winnipeg, Canada
• Inner Mongolia Baotou City Central Hospital (Baotou Central Hospital) — Baotou Shi, China
• Peking University People's Hospital — Beijeing, China
• Peking University First Hospital — Beijing, China
• China Rehabilitation Research Center (Beijing Boai Hospital) — Beijing, China
• Peking University Third Hospital — Beijing, China
• Beijing Miyun Hospital — Beijing, China
• Beijing Tsinghua Chang Gung Hospital — Beijing, China
• Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (SAMSPH) — Chengdu, China
• The Affiliated Zhongshan Hospital (Dalian Railroad Hospital) — Dalian, China
• People's Hospital of Deyang — Deyang Shi, China
• Dongguan People's Hospital — Dongguan, China
• The First People's Hospital - Foshan — Foshan Shi, China
• The Fifth Affiliated Hospital of Guangzhou Medical University — Guangzhou, China
• Anhui Medical University-The Second Hospital — Hefei, China
• The First Hospital of Jiaxing — Jiaxing, China
• Jiangsu Province Hospital /The First Affiliated Hospital with Nanjing Medical University — Lanzhou, China
• Gansu Provincial People's Hospital — Lanzhou, China
• Henan University of Science and Technology-The First Affiliated Hospital — Luoyang Shi, China
• The Third Hospital of Mianyang — Mianyang, China
• Nanchang University - The First Affiliated Hospital — Nanchang, China
• The Second Affiliated Hospital of Nanjing Medical University — Nanjing, China
• Jiangsu Province Hospital of Chinese Medicine — Nanjing, China
• The People's Hospital Guangxi Zhuang of Autonomous Region — Nanning, China
• Southern Medical University - Jiangxi Pingxiang People's Hospital — Pingxiang, China
• Shanghai Jiao Tong University School of Medicine (SJTUSM)-Renji Hospital — Shanghai, China
• Shanghai First People's Hospital — Shanghai Shi, China
• Shenzhen Second People's Hospital (Shenzhen University First Affiliated Hospital) — Shenzhen, China
• Shijiazhuang People's Hospital — Shijiazhuang, China
• The Fourth Hospital of Hebei Medical University — Shijiazhuang, China
• Second Hospital of Shanxi Medical University — Taiyuan, China
• Tianjin People's Hospital — Tianjin, China
• Huazhong University of Science and Technology - Tongji Medical College - The Central Hospital of Wuhan (Wuhan Second Hospital) — Wuhan, China
• Renmin Hospital of Wuhan University/Hubei General Hospital — Wuhan, China
• Wuxi People's Hospital — Wuxi, China
• Zhongshan Hospital Xiamen University — Xiamen, China
• Yan'an University Xianyang Hospital — Xianyang, China
• Xinxiang City First People's Hospital — Xinxiang, China
• Northern Jiangsu People's Hospital — Yangzhou, China
• Yibin Second People's Hospital — Yibin, China
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, China
• Affiliated Hospital of Jiangsu University — Zhenjiang, China
• Interni Oddeleni Nemocnice — Český Krumlov, Czechia
• Fakultni Nemocnice Hradec Kralove (FNHK) - Hemodialyzacni Stredisko (HDS) — Hradec Králové, Czechia
• Nemocnice AGEL Novy Jicin a.s — Nový Jičín, Czechia
• Fakultní Nemocnice Ostrava (FNO) - Interni Klinika — Ostrava, Czechia
• Fakultní nemocnice Královské Vinohrady — Prague, Czechia
• Aalborg Universitetshospital — Aalborg, Denmark
• Herlev Hospital — Herlev, Denmark
• Gødstrup Hospital — Herning, Denmark
• Trail Nation: Nordsjællands Hospital — Hillerød, Denmark
• Holbæk Sygehus — Holbæk, Denmark
• CHU Amiens - Nephrology Dialysi Transplantation Department — Amiens, France
• CHU de Saint-Étienne - Hôpital Nord — Aura, France
• Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche — Brest, France
• CHU de Caen — Caen, France
• Polyclinique Saint Come - Centre de Dialyse — Compiègne, France
• Fondation Charles Mion AIDER Santé — Grabels, France
• Hopital Prive La Louviere — Lille, France
• CHU de Limoges — Limoges, France
• Hopitaux Universitaires de Marseille — Marseille, France
• Centre Hospitalier Universitaire Montpellier - Hôpital Lapeyronie — Montpellier, France
• CHE de Nice - Pasteur Hospital — Nice, France
• CHU de Nimes - Hopital Universitaire Caremeau — Nîmes, France
• Hopital Pitie-Salpetriere — Paris, France
• AURA Paris - Plaisance — Paris, France
• Centre Hospitalier Universitaire (CHU) de Reims - Hopital Maison Blanche — Reims, France
• AURA St Quen Dialysis centre — Saint-Ouen, France
• Hôpitaux Universitaires de Strasbourg - Hôpital Civil — Strasbourg, France
• CHU Rangueil — Toulouse, France
• Charite-Universitatsmedizin Berlin — Berlin, Germany
• Nierenzentrum Bad König — Hessen, Germany
• Westpfalz Klinikum GmbH — Kaiserslautern, Germany
• UKSH - Universitatsklinik Schleswig-Holstein — Kiel, Germany
• Kuratorium fuer Dialyse und Nierentransplantation e.V. - KfH-Nierenzentrum - St. Georg — Leipzig, Germany
• Universitätsmedizin der Johannes Gutenberg-Universität Mainz — Mainz, Germany
• Nephrologisches Zentrum Villingen-Schwenningen — Villingen-Schwenningen, Germany
• University Hospital of Alexandroupolis — Alexandroupoli, Greece
• General Hospital of Arta — Arta, Greece
• Korgialenio-Benakio Hellenic Red Cross Hospital — Athens, Greece
• University General Hospital of Heraklion — Crete, Greece
• Mesogeios Nephrology Center — Haidari, Greece
• University General Hospital of Ioannina — Ioannina, Greece
• General Hospital of Ioannina G. Hatzikosta — Ioannina, Greece
• Nephrological Clinic University Hospital, University of Thessaly — Larissa, Greece
• Mitera Hospital, Hemodialysis Unit — Marousi, Greece
• General Hospital of Ptolemaida — Ptolemaida, Greece
• University Hospital of Patras — Rio, Greece
• AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki — Thessaloniki, Greece
• Aristotle University, Hippokration — Thessaloniki, Greece
• General Hospital of Thessaloniki, Agios Pavlos — Thessaloniki, Greece
• Papageorgiou General Hospital of Thessaloniki — Thessaloniki, Greece
• Nephrology Department G. Papanikolaou General Hospital — Thessaloniki, Greece
• Princess Margaret Hospital — Ho Man Tin, Hong Kong
• Queen Mary Hospital Hong Kong — Pok Fu Lam, Hong Kong
• Yan Chai Hospital — Tsuen Wan, Hong Kong
• Somogy Megyei Kaposi Mor Oktato Korhaz — Kaposvár, Hungary
• B. Braun Avitum - 14. Dialízisközpont Kistarcs — Kistarcsa, Hungary
• Emek Medical Center — Afula, Israel
• Barzilai Medical Center — Ashkelon, Israel
• Carmel Medical Center — Haifa, Israel
• Edith Wolfson Medical Center — Holon, Israel
• Galilee Medical Center — Nahariya, Israel
• Rabin Medical Center — Petah Tikva, Israel
• Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center ) — Ramat Gan, Israel
• Kaplan Medical Center — Rehovot, Israel
• Ziv Medical Center — Safed, Israel
• Ichilov Hospital-Tel-Aviv Sourasky Medical Center — Tel Aviv, Israel
• Medical Research & Development Fund for Health Services, PORIYA Hospital — Tiberias, Israel
• Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi — Bologna, Italy
• ASST degli Spedali Civili di Brescia — Brescia, Italy
• Azienda Ospedaliera Brotzu — Cagliari, Italy
• Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta — Caserta, Italy
• AOU Policlinico G Rodolico - San Marco - Presidio Ospedaliero ospedale San Marco — Catania, Italy
• Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna — Ferrara, Italy
• Ospedale Santa Maria Annunziata — Florence, Italy
• A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp — Foggia, Italy
• IRCCS Az. Osp. Universitaria San Martino- IST — Genova, Italy
• Vito Fazzi Hospital in Lecce — Lecce, Italy
• ASST di Lecco - Presidio Ospedaliero A. Manzoni di Lecco — Lecco, Italy
• Università degli Studi di Messina — Messina, Italy
• ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo — Milan, Italy
• IRCCS Ospedale San Raffaele — Milan, Italy
• ASST Great Metropolitan Hospital Niguarda — Milan, Italy
• AOU L. Vanvitelli Universita degli Studi della Campania Luigi Vanvitelli — Naples, Italy
• Ospedale Maggiore di Novara — Novara, Italy
• ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS — Pavia, Italy
• University of Verona — Peschiera del Garda, Italy
• AUSL Piacenza Hospital-Unit Nephrology Dialysis, Dept of Medicine — Piacenza, Italy
• Azienda Ospedaliero Universitaria Pisana - Ospedale di Cisanello - Stabilimento Ospedaliero di Cisanello — Pisana, Italy
• Ospedale Santo Stefan — Prato, Italy
• Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli — Reggio Calabria, Italy
• Rimini Hospital — Rimini, Italy
• Policlinico A. Gemelli Universitario — Roma, Italy
• Azienda Unita Sanitaria Locale (USL) Roma 3 (AUSL RM 3) - Presidio Ospedaliero Giovan Battista Grassi — Rome, Italy
• Sandro Pertini Hospital — Rome, Italy
• Ospedale Casa Sollievo della Sofferenza (CSS) — San Giovanni Rotondo, Italy
• Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento — Verona, Italy
• Daiyukai Daiichi Hospital — Ichinomiya-shi, Aichi-ken, Japan
• Juntendo University Urayasu Hospital — Urayasu-shi, Chiba, Japan
• Steel Memorial Yawata Hospital — Kitakyushu-shi, Fukuoka, Japan
• Maebashi Hirosegawa Clinic — Maebashi, Gunma, Japan
• Joumou Ohashi Clinic — Maebashi, Gunma, Japan
• Teine Urological Clinic — Sapporo, Hokkaido, Japan
• Omi freai Hospital — Kusatsu-shi, Shiga, Japan
• Tokyo Womens Med University — Shinjuku-Ku, Tokyo, Japan
• Matsunami General Hospital — Hashima-gun, Japan
• Ishikiriseiki Hospital — Higashiosaka-shi, Japan
• NHO Hiroshimanishi Medical Center — Hiroshima, Japan
• Miki Internal Medicine Urology Clinic — Hokkaido, Japan
• University of Tsukuba - Mito Kyodo General Hospital — Ibaraki, Japan
• Tokyo Medical University Ibaraki Medical Center — Inashiki-gun, Japan
• Ueyama Hospital — Kagoshima, Japan
• Ueyama Jin Clinic — Kagoshima, Japan
• Shonan Kamakura General Hospital — Kamakura-Shi, Japan
• National Hospital Organization Kanazawa Medical Center — Kanazawa, Japan
• Kokura Memorial Hospital — Kitakyushu-Shi, Japan
• Kurume University Hospital — Kurume, Japan
• St. Mary's Hospital — Kurume-shi, Japan
• Rakuwakai Otowa Kinen Hospital — Kyoto, Japan
• Matsubara Tokushukai Hospital — Matsubara-shi, Japan
• Nagaoka Red-Cross Hospital — Nagaoka-Shi, Japan
• Chubu Rosai Hospital — Nagoya, Japan
• Daido Hospital — Nagoya, Japan
• Ogaki Tokushukai Hospital — Ogaki-Shi, Japan
• Oguranaika Jin Cinic — Oyama-shi, Japan
• Omihachiman Community Medical Center - Kidney Center — Ōmihachiman, Japan
• Ibaraki Seinan Medical Center Hospital — Sakaimachi, Japan
• Kurosawa Hospital — Takasaki-Shi, Japan
• Kikuchi Medical Clinic — Tsukuba, Japan
• St.Hill Hospital — Ube-shi, Japan
• Yamagata Tokushukai Hospital — Yamagata, Japan
• Bosei Kannai Clinic — Yokohama, Japan
• Sanin Rosai Hospital — Yonago-shi, Japan
• Hospital Raja Permaisuri Bainun, Ipoh — Ipoh, Malaysia
• Queen Elizabeth Hospital — Kota Kinabalu, Malaysia
• University Malaya Medical Centre — Lembah Pantai, Malaysia
• Hospital Kuala Lumpur — Pejabat Pakar, Malaysia
• Seberang Jaya Hospital — Perai, Malaysia
• Seri Manjung Hospital — Perak, Malaysia
• Medica Santa Carmen — Mexico City, Mexico
• Servicios de Oncologia Medica SA de CV (Renal Center) — Monterrey, Mexico
• Gelre Ziekenhuizen — Apeldoorn, Netherlands
• Catharina hospital — Eindhoven, Netherlands
• Franciscus Gasthuis & Vlietland — Rotterdam, Netherlands
• Vestre Viken HF - Drammen Sykehus (Sykehuset Buskerud) — Drammen, Norway
• Sykehuset Østfold Kalnes — Grålum, Norway
• Sykehuset Telemark — Skien, Norway
• Davita Stacja Dializ w Brodnicy — Brodnica, Poland
• Slaski Uniwersytet Medyczny (SUM) w Katowicach — Katowice, Poland
• Uniwersytecki Szpital Kliniczny Nr. 1 im. Norberta Barlickiego — Lodz, Poland
• Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodz, Klinika Nefrologii, Hipertensjologii i Transplantologii Nerek — Lodz, Poland
• Davita- Naklo n. Notecią — Naklo N. Notecią, Poland
• DaVita Stacja Dializ — Pszczyna, Poland
• Powiatowy Szpital Specjalistyczny w Stalowej Woli — Stalowa Wola, Poland
• Samodzielny Publiczny Szpital Kliniczny Nr. 2 Pomorski Uniwersytet Medyczny w Szczecinie — Szczecin, Poland
• Diaverum - NZOZ Tczewie — Tczew, Poland
• DaVita Stacja Dializ — Warsaw, Poland
• Klinika Chorob Wewnetrznych, Nefrologii i Transplantologii, CSK MSWiA — Warsaw, Poland
• Wojskowy Instytut Medyczny (WIM) - Centralny Szpital Kliniczny (CSK) MON - Klinika Chorob Wewnetrznych — Warsaw, Poland
• Davita-Łęczna — Łęczna, Poland
• Unidade Local de Saúde de Braga, E. P. E. — Braga, Portugal
• Caledial - Centro de Hemodiálise de Gaia — Canelas-V.N.Gaia, Portugal
• NephroCare Carregado — Carregado, Portugal
• Nephrocare Faro — Faro, Portugal
• Centro Hospitalar e Universitário de Lisboa Centra — Lisbon, Portugal
• Fresenius Medical Care - NephroCare - Unidade de Hemodialise do Restelo — Lisbon, Portugal
• Unidade Local de Saúde de Loures -Odivelas, E. P. E. — Loures, Portugal
• Unidade Local de Saúde de São José, E. P. E. — Oeiras, Portugal
• Unidade Local de Saúde de Santo António, E. P. E. — Porto, Portugal
• Fresenius NephroCare — Porto, Portugal
• Unidade Local de Saúde do Médio Tejo, E. P. E. — Torres Novas, Portugal
• Unidade Local de Saúde do Estuário do Tejo, E. P. E. — Vila Franca de Xira, Portugal
• Legacy Senior Living — Humacao, Puerto Rico
• Centrul de Dializa Fresenius NephroCare Brasov — Brasov, Romania
• Institutul National de Diabet, Nutriţie şi Boli Metabolice - Prof. Dr. N. Paulescu - Central — Bucharest, Romania
• SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center — Bucharest, Romania
• Centrul De Nefrologie si Dializa DIAVERUM SPLAI — Bucharest, Romania
• Centrul de Dializa Fresenius NephroCare Bucaresti — Bucharest, Romania
• Fundeni Clinical Institute — Bucharest, Romania
• Centrul de Nefrologie si Dializa DIAVERUM Sema Parc — Bucharest, Romania
• Centrul de Nefrologie si Dializa Diaverum Fundeni — Bucharest, Romania
• Centrul de Dializa Fresenius NephroCare Cluj — Cluj-Napoca, Romania
• Centrul de Dializa Fresenius NephroCare Constanta — Constanța, Romania
• Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta) — Constanța, Romania
• Centrul de Nefrologie si Dializa Diaverum Craiova — Craiova, Romania
• Spitalul Judetean de Urgenta Deva — Deva, Romania
• Spitalul Clinic -Dr. C.I. Parhon - Iasi — Iași, Romania
• Spitalul Clinic Municipal Dr. Gavril Curteanu Oradea — Oradea, Romania
• Centrul de Dializa Fresenius NephroCare Ploiesti — Ploieşti, Romania
• Spital Judetean de Urgenta Satu Mare — Satu Mare, Romania
• Centrul Medical de Nefrologie si Dializa Diaverum Targu Mures — Târgu Mureş, Romania
• Nefrologicka ambulancia Levice - FMC dialyzacne sluzby, s.r.o. — Levice, Slovakia
• LC-REN s.r.o. — Lučenec, Slovakia
• Biodial, s.r.o. — Púchov, Slovakia
• SMG - SNU Boramae Medical Center — Ilsan-gu, Seoul, South Korea
• Hallym University Sacred Heart Hospital — Anyang-si, South Korea
• Keimyung University Dongsan Medical Center — Daegu, South Korea
• Gangnam Severance Hospital — Gangnam-gu, South Korea
• National Health Insurance Service - Ilsan Hospital — Goyang-si, South Korea
• Hanyang University Guri Hospital — Guri-si, South Korea
• Konkuk University Medical Center — Gwangju, South Korea
• Seoul National University Hospital — Seoul, South Korea
• Severance Hospital, Yonsei University — Seoul, South Korea
• Yonsei University - Wonju Severance Christian Hospital — Wŏnju, South Korea
• Centro de dialisis Alcobendas — Alcobendas, Spain
• Hospital Universitari de Bellvitge (IDIBELL) — Barcelona, Spain
• Hospital Universitario Valle de Hebron — Barcelona, Spain
• University Hospital Reina Sofía — Córdoba, Spain
• Hospital Universitari de Girona Dr Josep Trueta, (Avitum) — Girona, Spain
• Hospital Universitario Virgen de las Nieves — Granada, Spain
• Universidad de Alcala (UAH) — Guadalajara, Spain
• Hospital Universitari Arnau de Vilanova — Lleida, Spain
• Hospital Universitario de La Princesa — Madrid, Spain
• Universitario Gregorio Marañón — Madrid, Spain
• Hospital Clínico San Carlos — Madrid, Spain
• Hospital Universitario Fundacion Jimenez Diaz — Madrid, Spain
• Hospital Universitario Príncipe de Asturias — Madrid, Spain
• Hospital de Manises — Manises, Spain
• Hospital Universitari Son Espases — Palma de Mallorca, Spain
• CHUS - H. Clinico U. de Santiago — Santiago de Compostela, Spain
• Hospital Universitario Virgen de la Macarena — Seville, Spain
• Fresenius Medical Care Centro de Diálisis Terrassa — Terrassa, Spain
• Hospital Clinico Universitario - Valencia — Valencia, Spain
• Centro Hospital Universitario Dr. Preset — Valencia, Spain
• Hospital Universitari i Politècnic La Fe — Valencia, Spain
• Karolinska Huddinge — Huddinge, Sweden
• Region Stockholm-SLSO — Stockholm, Sweden
• Uppsala Universitet - Akademiska Sjukhuset — Uppsala, Sweden
• Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
• Jiangxi Provincial People's Hospital — Nanchang, Taiwan
• The First People's Hospital of Nanning — Nanning Shi, Taiwan
• Far Eastern Memorial Hospital — New Taipei City, Taiwan
• Taipei Medical University Shuang Ho Hospital — New Taipei City, Taiwan
• Taichung Veterans General Hospital — Taichung, Taiwan
• Taipei Medical University - Taipei Medical University Hospital — Taipei, Taiwan
• Maharat Nakhon Ratchasima Hospital — Amphoe Mueang, Thailand
• Ramathibodi Hospital — Bangkok, Thailand
• Chiang Mai University — Chiang Mai, Thailand
• Hacettepe University,Faculty of Medicine — Ankara, Turkey (Türkiye)
• Akdeniz University Medical Faculty Hospital — Antalya, Turkey (Türkiye)
• Ondokuz Mayis Üniversitesi — Atakum, Turkey (Türkiye)
• İstanbul Bakirköy Dr.Sadi Konuk Eğitim Araştirma Hastanesi — Bakırköy, Turkey (Türkiye)
• Ege University Hospital — Bornova, Turkey (Türkiye)
• Trakya Üniversitesi Tıp Fakültesi — Edirne, Turkey (Türkiye)
• Gaziantep University — Gaziantep, Turkey (Türkiye)
• Kocaeli University, Medical Faculty, Division of Nephrology — İzmit, Turkey (Türkiye)
• Kahramanmaras Sutcu Imam University - Tip Fakultesi (Kahramanmaras Sutcu Imam University Faculty of Medicine) — Kahramanmaraş, Turkey (Türkiye)
• Malatya Education and Research Hospital — Yeşilyurt, Turkey (Türkiye)
• University Hospitals Birmingham NHS Foundation Trust - Birmingham Heartlands Hospital (BHH) — Birmingham, United Kingdom
• Bradford Teaching Hospitals NHS Foundation Trust — Bradford, United Kingdom
• University Hospital Coventry and Warwickshire — Coventry, United Kingdom
• University Hospitals of Derby and Burton NHS Foundation Trust - Royal Derby Hospital — Derby, United Kingdom
• Dorset County Hospital NHS Foundation Trust - Dorset County Hospital (DCH) — Dorchester, United Kingdom
• Royal Liverpool University Hospital — Liverpool, United Kingdom
• William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital — London, United Kingdom
• King´s College NHS Trust — London, United Kingdom
• St George's University Hospitals NHS Foundation Trust - St G — London, United Kingdom
• Hammersmith Hospital Imperial College Healthcare NHS Trust -Hammersmith Hospital - West London Renal and Transplant Centre — London, United Kingdom
• Altnagelvin Area Hospital — Londonderry, United Kingdom
• Northern Care Alliance NHS Foundation Trust - Salford Royal NHS Foundation Trust-Salford Care Organisation — Salford, United Kingdom
• The Shrewsbury and Telford Hospital NHS Trust (SaTH) - Royal Shrewsbury Hospital — Shrewsbury, United Kingdom
• Royal Stoke University Hospital — Stoke-on-Trent, United Kingdom
• The Royal Wolverhampton NHS Trust - New Cross Hospital — Wolverhampton, United Kingdom