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RECRUITING Phase 2 ClinicalTrials.gov

Cannabis' Impact on Alcohol Consumption

Sponsor: Brown University • ClinicalTrials.gov ID: NCT05389930

Registry updated: 2026-10-05
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Description

This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consumed. Cannabis will be administered simultaneously with an alcohol-priming dose or alcohol placebo. The study will enroll up to 350 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly.

Interventions

  • THC-dominant cannabis (Drug)
    Smoked cannabis with 9.53% THC and 0.09% CBD
  • CBD-dominant cannabis (Drug)
    Smoked cannabis with 0.35% THC and 11.27% CBD
  • Cannabis placebo (Drug)
    Smoked placebo cannabis plant material
  • Alcohol (Drug)
    Drink containing 0.3 g/kg of alcohol
  • Alcohol placebo (Drug)
    Placebo beverage contains only juice and a negligible trace of alcohol for masking

Eligibility criteria

Inclusion Criteria: * Age 21 to 50 * English-speaking * cannabis smoking in past two months * heavy drinking in past two months * in good physical health and weighing \< 250 lbs * zero breath alcohol at each visit Exclusion Criteria: * positive pregnancy test * nursing * positive urine toxicology screen for drugs other than cannabis * interest to quit or receive treatment for cannabis or alcohol use

Conditions

Alcohol Drinking Cannabis Use Cannabis Alcohol Use Disorder

Locations

  • Brown University — Providence, Rhode Island, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record