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Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules

Sponsor: City of Hope Medical Center • ClinicalTrials.gov ID: NCT05229341

Registry updated: 2026-10-16

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Description

This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.

Interventions

Diagnostic Procedure (Procedure)
Analysis via DDMS-2
Electronic Health Record Review (Other)
Review of medical records
Needle Biopsy (Procedure)
Undergo needle biopsy

Eligibility criteria

Inclusion Criteria: * Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis * Over the age of 18 * Any gender, race and ethnicity * Patients must provide informed consent prior to use of their tissues and clinical data Exclusion Criteria: * Children are excluded from the study, since the biology of children thyroid nodules is different from adults

Conditions

Thyroid Gland Carcinoma

Locations

City of Hope Medical Center — Duarte, California, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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